p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells

p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells

<p dir="ltr">The restoration of p53 has been suggested as a therapeutic approach in tumors. However, the timing of p53 restoration in relation to its efficacy during tumor progression still is unclear. We now show that the restoration of p53 in murine premalignant proliferating pinea...

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Bibliographic Details
Main Author: Mohamad Harajly (18810850) (author)
Other Authors: Hasan Zalzali (18810853) (author), Zafar Nawaz (96166) (author), Sandra E. Ghayad (7353428) (author), Farah Ghamloush (9449144) (author), Hussein Basma (18810856) (author), Samiha Zainedin (18810859) (author), Wissam Rabeh (18810862) (author), Mark Jabbour (631068) (author), Ayman Tawil (6442628) (author), Danielle A. Badro (9155014) (author), Gerard I. Evan (13984602) (author), Raya Saab (7353425) (author)
Published: 2023
Subjects:
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Oncology and carcinogenesis
Tumor suppression
Tumor progression
Premalignant tumors
Invasive tumors
Tumor reentry
Neuroectodermal tumors
DNA-damaging therapy
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