Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease

Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease

<h3>Background & Aims</h3><p dir="ltr">The gastrointestinal epithelium plays a crucial role in maintaining homeostasis with the gut microbiome. Mucins are essential for intestinal barrier function and serve as a scaffold for antimicrobial factors. Mucin 2 (MUC2) is th...

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Bibliographic Details
Main Author: Ahmad A. Al-Shaibi (18552234) (author)
Other Authors: Ussama M. Abdel-Motal (138406) (author), Satanay Z. Hubrack (18552236) (author), Alex N. Bullock (18552237) (author), Amna A. Al-Marri (18552239) (author), Nourhen Agrebi (14151222) (author), Abdulrahman A. Al-Subaiey (18552242) (author), Nazira A. Ibrahim (18552247) (author), Adrian K. Charles (112557) (author), Mamoun Elawad (438979) (author), Holm H. Uhlig (564856) (author), Bernice Lo (3441317) (author)
Published: 2021
Subjects:
Biological sciences
Biochemistry and cell biology
Genetics
Biomedical and clinical sciences
Clinical sciences
AGR2
MUC2
ER Stress
Intestinal Metaplasia
Goblet Cells
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