Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review
<p dir="ltr">Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed mark...
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2025
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| Summary: | <p dir="ltr">Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemia (peak: 650 μmol/L) with elevated ALP (366 U/L). Viral, autoimmune, and biliary causes were excluded. Liver biopsy confirmed cholestasis. Carbimazole was discontinued, corticosteroids initiated, and radioiodine therapy planned. Bilirubin levels gradually improved over 8 weeks. Carbimazole‐induced cholestasis, though rare, necessitates prompt recognition and alternative hyperthyroidism management. Routine liver monitoring is crucial.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70498" target="_blank">https://dx.doi.org/10.1002/ccr3.70498</a></p> |
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