Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review
<p dir="ltr">Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed mark...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513533168844800 |
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| author | Bassem Al Hariri (19180066) |
| author2 | Mohammed Omer Elbadawi Elhassan (22565375) Hadil Altaj Altrify Alsidig (22565378) Muad Abdi Hassan (21841835) Abdalrahman Mohammed Mostafa (19180075) Memon Noor Illahi (22565381) |
| author2_role | author author author author author |
| author_facet | Bassem Al Hariri (19180066) Mohammed Omer Elbadawi Elhassan (22565375) Hadil Altaj Altrify Alsidig (22565378) Muad Abdi Hassan (21841835) Abdalrahman Mohammed Mostafa (19180075) Memon Noor Illahi (22565381) |
| author_role | author |
| dc.creator.none.fl_str_mv | Bassem Al Hariri (19180066) Mohammed Omer Elbadawi Elhassan (22565375) Hadil Altaj Altrify Alsidig (22565378) Muad Abdi Hassan (21841835) Abdalrahman Mohammed Mostafa (19180075) Memon Noor Illahi (22565381) |
| dc.date.none.fl_str_mv | 2025-06-19T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/ccr3.70498 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cholestatic_Hepatic_Injury_Induced_by_Carbimazole_A_Case_Report_and_a_Thorough_Literature_Review/30541370 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences carbimazole cholestatic liver injury drug-induced liver injury (DILI) hepatotoxicity hyperthyroidism thionamide therapy |
| dc.title.none.fl_str_mv | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemia (peak: 650 μmol/L) with elevated ALP (366 U/L). Viral, autoimmune, and biliary causes were excluded. Liver biopsy confirmed cholestasis. Carbimazole was discontinued, corticosteroids initiated, and radioiodine therapy planned. Bilirubin levels gradually improved over 8 weeks. Carbimazole‐induced cholestasis, though rare, necessitates prompt recognition and alternative hyperthyroidism management. Routine liver monitoring is crucial.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70498" target="_blank">https://dx.doi.org/10.1002/ccr3.70498</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8ac957f570dd82f338cc6642e545da98 |
| identifier_str_mv | 10.1002/ccr3.70498 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30541370 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature ReviewBassem Al Hariri (19180066)Mohammed Omer Elbadawi Elhassan (22565375)Hadil Altaj Altrify Alsidig (22565378)Muad Abdi Hassan (21841835)Abdalrahman Mohammed Mostafa (19180075)Memon Noor Illahi (22565381)Biomedical and clinical sciencesMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencescarbimazolecholestatic liver injurydrug-induced liver injury (DILI)hepatotoxicityhyperthyroidismthionamide therapy<p dir="ltr">Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemia (peak: 650 μmol/L) with elevated ALP (366 U/L). Viral, autoimmune, and biliary causes were excluded. Liver biopsy confirmed cholestasis. Carbimazole was discontinued, corticosteroids initiated, and radioiodine therapy planned. Bilirubin levels gradually improved over 8 weeks. Carbimazole‐induced cholestasis, though rare, necessitates prompt recognition and alternative hyperthyroidism management. Routine liver monitoring is crucial.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70498" target="_blank">https://dx.doi.org/10.1002/ccr3.70498</a></p>2025-06-19T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/ccr3.70498https://figshare.com/articles/journal_contribution/Cholestatic_Hepatic_Injury_Induced_by_Carbimazole_A_Case_Report_and_a_Thorough_Literature_Review/30541370CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/305413702025-06-19T09:00:00Z |
| spellingShingle | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review Bassem Al Hariri (19180066) Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences carbimazole cholestatic liver injury drug-induced liver injury (DILI) hepatotoxicity hyperthyroidism thionamide therapy |
| status_str | publishedVersion |
| title | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_full | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_fullStr | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_full_unstemmed | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_short | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_sort | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences carbimazole cholestatic liver injury drug-induced liver injury (DILI) hepatotoxicity hyperthyroidism thionamide therapy |