Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea
<p><br></p><p dir="ltr">Rosacea affects at least 20 million people worldwide and is characterized by erythema, papules, pustules, telangiectasia, fibrosis, and burning sensation of the facial skin (<a href="" target="_blank">Steinhoff and B...
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2025
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| _version_ | 1864513533675307008 |
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| author | Ioannis N. Petropoulos (8748726) |
| author2 | Joerg Buddenkotte (6293584) Febu Joy (19325689) Noor Al Nassr (22502864) Hanof Ahmed (16494866) Roudha Al Dehneem (22502867) Ayda Al Hammadi (22502870) Khairunnisa Hussain (22502873) Hanaan Al Maslamani (22502876) Aysha Al-Malki (22502879) Seena Manjooran (22502882) Anh Jochebeth (17017782) Safaa Elmoh (22502885) Arish Hussain (22502888) Rayaz A. Malik (7372649) Martin Steinhoff (5340194) |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Ioannis N. Petropoulos (8748726) Joerg Buddenkotte (6293584) Febu Joy (19325689) Noor Al Nassr (22502864) Hanof Ahmed (16494866) Roudha Al Dehneem (22502867) Ayda Al Hammadi (22502870) Khairunnisa Hussain (22502873) Hanaan Al Maslamani (22502876) Aysha Al-Malki (22502879) Seena Manjooran (22502882) Anh Jochebeth (17017782) Safaa Elmoh (22502885) Arish Hussain (22502888) Rayaz A. Malik (7372649) Martin Steinhoff (5340194) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ioannis N. Petropoulos (8748726) Joerg Buddenkotte (6293584) Febu Joy (19325689) Noor Al Nassr (22502864) Hanof Ahmed (16494866) Roudha Al Dehneem (22502867) Ayda Al Hammadi (22502870) Khairunnisa Hussain (22502873) Hanaan Al Maslamani (22502876) Aysha Al-Malki (22502879) Seena Manjooran (22502882) Anh Jochebeth (17017782) Safaa Elmoh (22502885) Arish Hussain (22502888) Rayaz A. Malik (7372649) Martin Steinhoff (5340194) |
| dc.date.none.fl_str_mv | 2025-09-19T15:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jid.2025.03.047 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Corneal_Confocal_Microscopy_Identifies_Neurodegeneration_in_Relation_to_Disease_Severity_and_Neuropathic_Symptoms_in_Rosacea/30455015 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Biomarker Corneal confocal microscopy Neurodegeneration Neuropathy Rosacea |
| dc.title.none.fl_str_mv | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p><br></p><p dir="ltr">Rosacea affects at least 20 million people worldwide and is characterized by erythema, papules, pustules, telangiectasia, fibrosis, and burning sensation of the facial skin (<a href="" target="_blank">Steinhoff and Bergstresser, 2011</a>). The underlying pathophysiology of rosacea is complex, although neurogenic inflammation is thought to play an important role, and altered cutaneous sensitivity is a hallmark of rosacea (<a href="" target="_blank">Sulk et al, 2012</a>). Ocular rosacea may affect >50% of patients with rosacea and is characterized by dryness and foreign body sensation (<a href="" target="_blank">Sinikumpu et al, 2022</a>).</p><p dir="ltr">Corneal confocal microscopy (CCM) is a noninvasive ophthalmic imaging technique that has been used to identify neurodegeneration in diabetic and other peripheral and central neurodegenerative diseases (<a href="" target="_blank">Petropoulos et al, 2020</a>) and to identify corneal conjuctivalization (<a href="" target="_blank">De Nicola et al, 2005</a>) and meibomian and skin gland alterations (<a href="" target="_blank">Liang et al, 2017</a>) in patients with rosacea. We now seek to demonstrate the utility of CCM to assess neurodegeneration in relation to disease onset and progression, subtypes, and treatment efficacy in patients with rosacea.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Investigative Dermatology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jid.2025.03.047" target="_blank">https://dx.doi.org/10.1016/j.jid.2025.03.047</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8b046b962535b4653a2f32a966e05103 |
| identifier_str_mv | 10.1016/j.jid.2025.03.047 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30455015 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in RosaceaIoannis N. Petropoulos (8748726)Joerg Buddenkotte (6293584)Febu Joy (19325689)Noor Al Nassr (22502864)Hanof Ahmed (16494866)Roudha Al Dehneem (22502867)Ayda Al Hammadi (22502870)Khairunnisa Hussain (22502873)Hanaan Al Maslamani (22502876)Aysha Al-Malki (22502879)Seena Manjooran (22502882)Anh Jochebeth (17017782)Safaa Elmoh (22502885)Arish Hussain (22502888)Rayaz A. Malik (7372649)Martin Steinhoff (5340194)Biomedical and clinical sciencesClinical sciencesNeurosciencesBiomarkerCorneal confocal microscopyNeurodegenerationNeuropathyRosacea<p><br></p><p dir="ltr">Rosacea affects at least 20 million people worldwide and is characterized by erythema, papules, pustules, telangiectasia, fibrosis, and burning sensation of the facial skin (<a href="" target="_blank">Steinhoff and Bergstresser, 2011</a>). The underlying pathophysiology of rosacea is complex, although neurogenic inflammation is thought to play an important role, and altered cutaneous sensitivity is a hallmark of rosacea (<a href="" target="_blank">Sulk et al, 2012</a>). Ocular rosacea may affect >50% of patients with rosacea and is characterized by dryness and foreign body sensation (<a href="" target="_blank">Sinikumpu et al, 2022</a>).</p><p dir="ltr">Corneal confocal microscopy (CCM) is a noninvasive ophthalmic imaging technique that has been used to identify neurodegeneration in diabetic and other peripheral and central neurodegenerative diseases (<a href="" target="_blank">Petropoulos et al, 2020</a>) and to identify corneal conjuctivalization (<a href="" target="_blank">De Nicola et al, 2005</a>) and meibomian and skin gland alterations (<a href="" target="_blank">Liang et al, 2017</a>) in patients with rosacea. We now seek to demonstrate the utility of CCM to assess neurodegeneration in relation to disease onset and progression, subtypes, and treatment efficacy in patients with rosacea.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Investigative Dermatology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jid.2025.03.047" target="_blank">https://dx.doi.org/10.1016/j.jid.2025.03.047</a></p>2025-09-19T15:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jid.2025.03.047https://figshare.com/articles/journal_contribution/Corneal_Confocal_Microscopy_Identifies_Neurodegeneration_in_Relation_to_Disease_Severity_and_Neuropathic_Symptoms_in_Rosacea/30455015CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304550152025-09-19T15:00:00Z |
| spellingShingle | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea Ioannis N. Petropoulos (8748726) Biomedical and clinical sciences Clinical sciences Neurosciences Biomarker Corneal confocal microscopy Neurodegeneration Neuropathy Rosacea |
| status_str | publishedVersion |
| title | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| title_full | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| title_fullStr | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| title_full_unstemmed | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| title_short | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| title_sort | Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Biomarker Corneal confocal microscopy Neurodegeneration Neuropathy Rosacea |