The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study
<p dir="ltr">Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonadism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513545982443520 |
|---|---|
| author | Aksam Yassin (14779204) |
| author2 | Farid Saad (21623747) Mustafa Alwani (17787566) Omar M. Aboumarzouk (14779240) Raed M. Al-Zoubi (2037490) Joanne Nettleship (29762) Daniel Kelly (7412216) Abdulla Al-Ansari (14150583) |
| author2_role | author author author author author author author |
| author_facet | Aksam Yassin (14779204) Farid Saad (21623747) Mustafa Alwani (17787566) Omar M. Aboumarzouk (14779240) Raed M. Al-Zoubi (2037490) Joanne Nettleship (29762) Daniel Kelly (7412216) Abdulla Al-Ansari (14150583) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aksam Yassin (14779204) Farid Saad (21623747) Mustafa Alwani (17787566) Omar M. Aboumarzouk (14779240) Raed M. Al-Zoubi (2037490) Joanne Nettleship (29762) Daniel Kelly (7412216) Abdulla Al-Ansari (14150583) |
| dc.date.none.fl_str_mv | 2022-07-29T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1080/13685538.2022.2099828 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_effects_of_long-term_testosterone_treatment_on_endocrine_parameters_in_hypogonadal_men_12-year_data_from_a_prospective_controlled_registry_study/29435954 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Hypogonadism testoster-one endocrine SHBG estradiol gonadotropins |
| dc.title.none.fl_str_mv | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonadism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globulin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (<i>p</i> < 0.0001), a reduction in SHBG of 10.5 nmol/L (<i>p</i> < 0.0001) and an increase in calculated free T of 383.04 pmol/L (<i>p</i> < 0.0001) over the study period. This was accompanied by an increase in estradiol levels by 14.9 pmol/L (<i>p</i> < 0.0001), and decreases in progesterone (0.2 ng/mL, <i>p</i> < 0.0001), LH (10.4 U/L, <i>p</i> < 0.0001) and FSH (8.4 U/L, <i>p</i> < 0.0001) were demonstrated at 12-years. The levels of prolactin remained unchanged. Long-term TTh altered hormonal parameters to predictably modify the endocrine system. These effects were sustained during the entire observation time of 12 years.</p><h2>Other Information</h2><p dir="ltr">Published in: The Aging Male<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/13685538.2022.2099828" target="_blank">https://dx.doi.org/10.1080/13685538.2022.2099828</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8b2f94d956d0657fc017244268d4956d |
| identifier_str_mv | 10.1080/13685538.2022.2099828 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29435954 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry studyAksam Yassin (14779204)Farid Saad (21623747)Mustafa Alwani (17787566)Omar M. Aboumarzouk (14779240)Raed M. Al-Zoubi (2037490)Joanne Nettleship (29762)Daniel Kelly (7412216)Abdulla Al-Ansari (14150583)Biomedical and clinical sciencesMedical biochemistry and metabolomicsHypogonadismtestoster-oneendocrineSHBGestradiolgonadotropins<p dir="ltr">Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonadism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globulin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (<i>p</i> < 0.0001), a reduction in SHBG of 10.5 nmol/L (<i>p</i> < 0.0001) and an increase in calculated free T of 383.04 pmol/L (<i>p</i> < 0.0001) over the study period. This was accompanied by an increase in estradiol levels by 14.9 pmol/L (<i>p</i> < 0.0001), and decreases in progesterone (0.2 ng/mL, <i>p</i> < 0.0001), LH (10.4 U/L, <i>p</i> < 0.0001) and FSH (8.4 U/L, <i>p</i> < 0.0001) were demonstrated at 12-years. The levels of prolactin remained unchanged. Long-term TTh altered hormonal parameters to predictably modify the endocrine system. These effects were sustained during the entire observation time of 12 years.</p><h2>Other Information</h2><p dir="ltr">Published in: The Aging Male<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/13685538.2022.2099828" target="_blank">https://dx.doi.org/10.1080/13685538.2022.2099828</a></p>2022-07-29T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1080/13685538.2022.2099828https://figshare.com/articles/journal_contribution/The_effects_of_long-term_testosterone_treatment_on_endocrine_parameters_in_hypogonadal_men_12-year_data_from_a_prospective_controlled_registry_study/29435954CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294359542022-07-29T09:00:00Z |
| spellingShingle | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study Aksam Yassin (14779204) Biomedical and clinical sciences Medical biochemistry and metabolomics Hypogonadism testoster-one endocrine SHBG estradiol gonadotropins |
| status_str | publishedVersion |
| title | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| title_full | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| title_fullStr | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| title_full_unstemmed | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| title_short | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| title_sort | The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Hypogonadism testoster-one endocrine SHBG estradiol gonadotropins |