Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

<div><p>The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in cancer. Here, using an shRNA li...

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Bibliographic Details
Main Author:	Omar M. Khan (17807774) (author)
Other Authors:	Jorge Almagro (8692275) (author), Jessica K. Nelson (3775789) (author), Stuart Horswell (594411) (author), Vesela Encheva (4917094) (author), Kripa S. Keyan (17807771) (author), Bruce E. Clurman (18595726) (author), Ambrosius P. Snijders (3192861) (author), Axel Behrens (47682) (author)
Published:	2021
Subjects:	Biomedical and clinical sciences Oncology and carcinogenesis Tumour suppressor FBW7 E3 ubiquitin ligase SKP1-CUL1-F-box (SCF) complex Oncoproteins Proteasomal degradation Cancer
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