Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
<p dir="ltr">DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA pop...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , , , , , , , , , , , |
| Published: |
2020
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513554947768320 |
|---|---|
| author | Shaza B. Zaghlool (10836602) |
| author2 | Brigitte Kühnel (3342752) Mohamed A. Elhadad (9321662) Sara Kader (14152683) Anna Halama (545988) Gaurav Thareja (459188) Rudolf Engelke (1754893) Hina Sarwath (4480654) Eman K. Al-Dous (14152686) Yasmin A. Mohamoud (10671696) Thomas Meitinger (26605) Rory Wilson (332489) Konstantin Strauch (73658) Annette Peters (62601) Dennis O. Mook-Kanamori (148319) Johannes Graumann (1297758) Joel A. Malek (10327973) Christian Gieger (87555) Melanie Waldenberger (236985) Karsten Suhre (67967) |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_facet | Shaza B. Zaghlool (10836602) Brigitte Kühnel (3342752) Mohamed A. Elhadad (9321662) Sara Kader (14152683) Anna Halama (545988) Gaurav Thareja (459188) Rudolf Engelke (1754893) Hina Sarwath (4480654) Eman K. Al-Dous (14152686) Yasmin A. Mohamoud (10671696) Thomas Meitinger (26605) Rory Wilson (332489) Konstantin Strauch (73658) Annette Peters (62601) Dennis O. Mook-Kanamori (148319) Johannes Graumann (1297758) Joel A. Malek (10327973) Christian Gieger (87555) Melanie Waldenberger (236985) Karsten Suhre (67967) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shaza B. Zaghlool (10836602) Brigitte Kühnel (3342752) Mohamed A. Elhadad (9321662) Sara Kader (14152683) Anna Halama (545988) Gaurav Thareja (459188) Rudolf Engelke (1754893) Hina Sarwath (4480654) Eman K. Al-Dous (14152686) Yasmin A. Mohamoud (10671696) Thomas Meitinger (26605) Rory Wilson (332489) Konstantin Strauch (73658) Annette Peters (62601) Dennis O. Mook-Kanamori (148319) Johannes Graumann (1297758) Joel A. Malek (10327973) Christian Gieger (87555) Melanie Waldenberger (236985) Karsten Suhre (67967) |
| dc.date.none.fl_str_mv | 2020-01-03T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41467-019-13831-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epigenetics_meets_proteomics_in_an_epigenome-wide_association_study_with_circulating_blood_plasma_protein_traits/21598071 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Oncology and carcinogenesis Prostate Cancer (PC) Castration-Resistant Prostate Cancer Neuroendocrine Prostate Cancer (NEPC) miR-708 Apoptosis Tumor Xenografts |
| dc.title.none.fl_str_mv | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA population study and replication in a multi-ethnic cohort of 344 individuals. We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to chronic low-grade inflammation, including a network involving methylation of <i>NLRC5</i>, a regulator of the inflammasome, and associated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3, FCGR3B, and B2M. Our study links DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies correlative networks that may eventually be targeted in a personalized approach of chronic low-grade inflammation.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41467-019-13831-w" target="_blank">http://dx.doi.org/10.1038/s41467-019-13831-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8bbc6336abd29fc0efa6f89715a0ad8f |
| identifier_str_mv | 10.1038/s41467-019-13831-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598071 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traitsShaza B. Zaghlool (10836602)Brigitte Kühnel (3342752)Mohamed A. Elhadad (9321662)Sara Kader (14152683)Anna Halama (545988)Gaurav Thareja (459188)Rudolf Engelke (1754893)Hina Sarwath (4480654)Eman K. Al-Dous (14152686)Yasmin A. Mohamoud (10671696)Thomas Meitinger (26605)Rory Wilson (332489)Konstantin Strauch (73658)Annette Peters (62601)Dennis O. Mook-Kanamori (148319)Johannes Graumann (1297758)Joel A. Malek (10327973)Christian Gieger (87555)Melanie Waldenberger (236985)Karsten Suhre (67967)Biological sciencesBiochemistry and cell biologyGeneticsBiomedical and clinical sciencesOncology and carcinogenesisProstate Cancer (PC)Castration-Resistant Prostate CancerNeuroendocrine Prostate Cancer (NEPC)miR-708ApoptosisTumor Xenografts<p dir="ltr">DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA population study and replication in a multi-ethnic cohort of 344 individuals. We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to chronic low-grade inflammation, including a network involving methylation of <i>NLRC5</i>, a regulator of the inflammasome, and associated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3, FCGR3B, and B2M. Our study links DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies correlative networks that may eventually be targeted in a personalized approach of chronic low-grade inflammation.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41467-019-13831-w" target="_blank">http://dx.doi.org/10.1038/s41467-019-13831-w</a></p>2020-01-03T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41467-019-13831-whttps://figshare.com/articles/journal_contribution/Epigenetics_meets_proteomics_in_an_epigenome-wide_association_study_with_circulating_blood_plasma_protein_traits/21598071CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215980712020-01-03T21:00:00Z |
| spellingShingle | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits Shaza B. Zaghlool (10836602) Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Oncology and carcinogenesis Prostate Cancer (PC) Castration-Resistant Prostate Cancer Neuroendocrine Prostate Cancer (NEPC) miR-708 Apoptosis Tumor Xenografts |
| status_str | publishedVersion |
| title | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| title_full | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| title_fullStr | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| title_full_unstemmed | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| title_short | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| title_sort | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| topic | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Oncology and carcinogenesis Prostate Cancer (PC) Castration-Resistant Prostate Cancer Neuroendocrine Prostate Cancer (NEPC) miR-708 Apoptosis Tumor Xenografts |