Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
<h2>Backgrounds</h2> <p>Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of systematic reviews of adverse events....
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2022
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| _version_ | 1864513566600593408 |
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| author | Chang Xu (102022) |
| author2 | Xiaoqin Zhou (3368027) Liliane Zorzela (10970928) Ke Ju (8976416) Luis Furuya-Kanamori (477124) Lifeng Lin (2034385) Cuncun Lu (6535076) Omran A. H. Musa (10970931) Sunita Vohra (130014) |
| author2_role | author author author author author author author author |
| author_facet | Chang Xu (102022) Xiaoqin Zhou (3368027) Liliane Zorzela (10970928) Ke Ju (8976416) Luis Furuya-Kanamori (477124) Lifeng Lin (2034385) Cuncun Lu (6535076) Omran A. H. Musa (10970931) Sunita Vohra (130014) |
| author_role | author |
| dc.creator.none.fl_str_mv | Chang Xu (102022) Xiaoqin Zhou (3368027) Liliane Zorzela (10970928) Ke Ju (8976416) Luis Furuya-Kanamori (477124) Lifeng Lin (2034385) Cuncun Lu (6535076) Omran A. H. Musa (10970931) Sunita Vohra (130014) |
| dc.date.none.fl_str_mv | 2022-11-22T21:17:59Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12916-021-02008-2 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Utilization_of_the_evidence_from_studies_with_no_events_in_meta-analyses_of_adverse_events_an_empirical_investigation/21598395 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical sciences General Medicine |
| dc.title.none.fl_str_mv | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Backgrounds</h2> <p>Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of systematic reviews of adverse events.</p> <h2>Methods</h2> <p>We conducted a survey of systematic reviews published in two periods: January 1, 2015, to January 1, 2020, and January 1, 2008, to April 25, 2011. Databases were searched for systematic reviews that conducted at least one meta-analysis of any healthcare intervention and used adverse events as the exclusive outcome. An adverse event was defined as any untoward medical occurrence in a patient or subject in healthcare practice. We summarized the frequency of occurrence of zero-events studies in eligible systematic reviews and how these studies were dealt with in the meta-analyses of these systematic reviews.</p> <h2>Results</h2> <p>We included 640 eligible systematic reviews. There were 406 (63.45%) systematic reviews involving zero-events studies in their meta-analyses, among which 389 (95.11%) involved single-arm-zero-events studies and 223 (54.93%) involved double-arm-zero-events studies. The majority (98.71%) of these systematic reviews incorporated single-arm-zero-events studies into the meta-analyses. On the other hand, the majority (76.23%) of them excluded double-arm-zero-events studies from the meta-analyses, of which the majority (87.06%) did not discuss the potential impact of excluding such studies. Systematic reviews published at present (2015-2020) tended to incorporate zero-events studies in meta-analyses than those published in the past (2008-2011), but the difference was not significant (proportion difference=−0.09, 95% CI −0.21 to 0.03, p = 0.12).</p> <h2>Conclusion</h2> <p>Systematic review authors routinely treated studies with zero-events in both arms as “non-informative” carriers and excluded them from their reviews. Whether studies with no events are “informative” or not largely depends on the methods and assumptions applied, thus sensitivity analyses using different methods should be considered in future meta-analyses.</p><h2>Other Information</h2> <p> Published in: BMC Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12916-021-02008-2" target="_blank">http://dx.doi.org/10.1186/s12916-021-02008-2</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8bfd6fc92f74d7094f0fe5b4668dd873 |
| identifier_str_mv | 10.1186/s12916-021-02008-2 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598395 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigationChang Xu (102022)Xiaoqin Zhou (3368027)Liliane Zorzela (10970928)Ke Ju (8976416)Luis Furuya-Kanamori (477124)Lifeng Lin (2034385)Cuncun Lu (6535076)Omran A. H. Musa (10970931)Sunita Vohra (130014)Clinical sciencesGeneral Medicine<h2>Backgrounds</h2> <p>Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of systematic reviews of adverse events.</p> <h2>Methods</h2> <p>We conducted a survey of systematic reviews published in two periods: January 1, 2015, to January 1, 2020, and January 1, 2008, to April 25, 2011. Databases were searched for systematic reviews that conducted at least one meta-analysis of any healthcare intervention and used adverse events as the exclusive outcome. An adverse event was defined as any untoward medical occurrence in a patient or subject in healthcare practice. We summarized the frequency of occurrence of zero-events studies in eligible systematic reviews and how these studies were dealt with in the meta-analyses of these systematic reviews.</p> <h2>Results</h2> <p>We included 640 eligible systematic reviews. There were 406 (63.45%) systematic reviews involving zero-events studies in their meta-analyses, among which 389 (95.11%) involved single-arm-zero-events studies and 223 (54.93%) involved double-arm-zero-events studies. The majority (98.71%) of these systematic reviews incorporated single-arm-zero-events studies into the meta-analyses. On the other hand, the majority (76.23%) of them excluded double-arm-zero-events studies from the meta-analyses, of which the majority (87.06%) did not discuss the potential impact of excluding such studies. Systematic reviews published at present (2015-2020) tended to incorporate zero-events studies in meta-analyses than those published in the past (2008-2011), but the difference was not significant (proportion difference=−0.09, 95% CI −0.21 to 0.03, p = 0.12).</p> <h2>Conclusion</h2> <p>Systematic review authors routinely treated studies with zero-events in both arms as “non-informative” carriers and excluded them from their reviews. Whether studies with no events are “informative” or not largely depends on the methods and assumptions applied, thus sensitivity analyses using different methods should be considered in future meta-analyses.</p><h2>Other Information</h2> <p> Published in: BMC Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12916-021-02008-2" target="_blank">http://dx.doi.org/10.1186/s12916-021-02008-2</a></p>2022-11-22T21:17:59ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12916-021-02008-2https://figshare.com/articles/journal_contribution/Utilization_of_the_evidence_from_studies_with_no_events_in_meta-analyses_of_adverse_events_an_empirical_investigation/21598395CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215983952022-11-22T21:17:59Z |
| spellingShingle | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation Chang Xu (102022) Clinical sciences General Medicine |
| status_str | publishedVersion |
| title | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| title_full | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| title_fullStr | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| title_full_unstemmed | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| title_short | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| title_sort | Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation |
| topic | Clinical sciences General Medicine |