A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges
<p dir="ltr">Statin-induced necrotizing autoimmune myopathy is an immune-mediated necrotizing myopathy related to the use of statins. It is a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels. Stopping statin and the...
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2022
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| _version_ | 1864513548260999168 |
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| author | Anwar I. Joudeh (17734059) |
| author2 | Mhd Kutaiba Albuni (11721777) Sara Seife Hassen (14779063) Phool Iqbal (12217770) Elsaid Mohamed Aziz Bedair (21363563) Salah Mahdi (14779066) |
| author2_role | author author author author author |
| author_facet | Anwar I. Joudeh (17734059) Mhd Kutaiba Albuni (11721777) Sara Seife Hassen (14779063) Phool Iqbal (12217770) Elsaid Mohamed Aziz Bedair (21363563) Salah Mahdi (14779066) |
| author_role | author |
| dc.creator.none.fl_str_mv | Anwar I. Joudeh (17734059) Mhd Kutaiba Albuni (11721777) Sara Seife Hassen (14779063) Phool Iqbal (12217770) Elsaid Mohamed Aziz Bedair (21363563) Salah Mahdi (14779066) |
| dc.date.none.fl_str_mv | 2022-05-31T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2022/4647227 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_Case_Report_of_Statin-Induced_Immune-Mediated_Necrotizing_Myopathy_Treatment_Challenges/29069576 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Immune-mediated myopathy Proximal muscle weakness Creatine kinase elevation Anti-HMGCR antibodies Muscle biopsy |
| dc.title.none.fl_str_mv | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Statin-induced necrotizing autoimmune myopathy is an immune-mediated necrotizing myopathy related to the use of statins. It is a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels. Stopping statin and the use of immunosuppressive therapy are considered the mainstay therapy. Use of steroids in patients with inflammatory myopathy can be complicated by steroid-induced myopathy. Herein, we present a case of a 55-year-old patient with statin-induced necrotizing autoimmune myopathy based on the presence of proximal muscle weakness, magnetic resonance findings, suggestive muscle biopsy features, and positive anti-HMGCR autoantibodies. The patient was treated with triple immunosuppressive therapy with a particularly good response to intravenous immunoglobulin. This report highlights the importance of timely diagnosis and early use of combined immunosuppressive therapy to improve patients’ outcome affected by this rare disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Case Reports in Rheumatology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2022/4647227" target="_blank">https://dx.doi.org/10.1155/2022/4647227</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8c202e541cb4adedece54f16869dfbf0 |
| identifier_str_mv | 10.1155/2022/4647227 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29069576 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment ChallengesAnwar I. Joudeh (17734059)Mhd Kutaiba Albuni (11721777)Sara Seife Hassen (14779063)Phool Iqbal (12217770)Elsaid Mohamed Aziz Bedair (21363563)Salah Mahdi (14779066)Biomedical and clinical sciencesClinical sciencesNeurosciencesPharmacology and pharmaceutical sciencesImmune-mediated myopathyProximal muscle weaknessCreatine kinase elevationAnti-HMGCR antibodiesMuscle biopsy<p dir="ltr">Statin-induced necrotizing autoimmune myopathy is an immune-mediated necrotizing myopathy related to the use of statins. It is a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels. Stopping statin and the use of immunosuppressive therapy are considered the mainstay therapy. Use of steroids in patients with inflammatory myopathy can be complicated by steroid-induced myopathy. Herein, we present a case of a 55-year-old patient with statin-induced necrotizing autoimmune myopathy based on the presence of proximal muscle weakness, magnetic resonance findings, suggestive muscle biopsy features, and positive anti-HMGCR autoantibodies. The patient was treated with triple immunosuppressive therapy with a particularly good response to intravenous immunoglobulin. This report highlights the importance of timely diagnosis and early use of combined immunosuppressive therapy to improve patients’ outcome affected by this rare disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Case Reports in Rheumatology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2022/4647227" target="_blank">https://dx.doi.org/10.1155/2022/4647227</a></p>2022-05-31T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2022/4647227https://figshare.com/articles/journal_contribution/A_Case_Report_of_Statin-Induced_Immune-Mediated_Necrotizing_Myopathy_Treatment_Challenges/29069576CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290695762022-05-31T06:00:00Z |
| spellingShingle | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges Anwar I. Joudeh (17734059) Biomedical and clinical sciences Clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Immune-mediated myopathy Proximal muscle weakness Creatine kinase elevation Anti-HMGCR antibodies Muscle biopsy |
| status_str | publishedVersion |
| title | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| title_full | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| title_fullStr | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| title_full_unstemmed | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| title_short | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| title_sort | A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Immune-mediated myopathy Proximal muscle weakness Creatine kinase elevation Anti-HMGCR antibodies Muscle biopsy |