A case of adult-onset Bartter syndrome with transient paraplegia
<p dir="ltr">Bartter syndrome is a rare inherited renal tubular disorder characterised by metabolic alkalosis, hyperaldosteronism, and salt wasting due to defective salt reabsorption in the ascending loop of Henle. The disease is dominant in the antenatal and neonatal populations and...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
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إضافة وسم
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| _version_ | 1864513533627072512 |
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| author | Shahzaib Siddiqui (22503590) |
| author2 | Shayan Ali Irfan (22503593) Shahrukh Ahmed (22503596) Mirza Mehmood Ali Baig (19702599) Jawad Ahmed (5873762) Jawed Iqbal (518263) |
| author2_role | author author author author author |
| author_facet | Shahzaib Siddiqui (22503590) Shayan Ali Irfan (22503593) Shahrukh Ahmed (22503596) Mirza Mehmood Ali Baig (19702599) Jawad Ahmed (5873762) Jawed Iqbal (518263) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shahzaib Siddiqui (22503590) Shayan Ali Irfan (22503593) Shahrukh Ahmed (22503596) Mirza Mehmood Ali Baig (19702599) Jawad Ahmed (5873762) Jawed Iqbal (518263) |
| dc.date.none.fl_str_mv | 2025-07-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1093/omcr/omaf100 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_case_of_adult-onset_Bartter_syndrome_with_transient_paraplegia/30455471 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Batter syndrome hypokalemia transient paraplegia young adult salt wasting case-report |
| dc.title.none.fl_str_mv | A case of adult-onset Bartter syndrome with transient paraplegia |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Bartter syndrome is a rare inherited renal tubular disorder characterised by metabolic alkalosis, hyperaldosteronism, and salt wasting due to defective salt reabsorption in the ascending loop of Henle. The disease is dominant in the antenatal and neonatal populations and rare in adults. Only a small number of studies present adult-onset Bartter syndrome. We present a case of an adult with transient paraplegia diagnosed with Bartter syndrome. A 22-year-old man presented with sudden bilateral lower limb weakness and cramps for two days, with no history of diarrhoea, vomiting, diuretics, laxatives, or addiction. Biochemical studies revealed hypokalemia, metabolic alkalosis, raised urinary potassium levels and raised serum renin. The potassium replacement therapy was initially ineffective in improving symptoms. The raised urinary calcium to creatinine ratio and normal serum magnesium level were noted. There was no nephrocalcinosis, unlike previously reported cases.</p><h2>Other Information</h2><p dir="ltr">Published in: Oxford Medical Case Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/omcr/omaf100" target="_blank">https://dx.doi.org/10.1093/omcr/omaf100</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8db57e7b0162bdd4fded317c4989c0b4 |
| identifier_str_mv | 10.1093/omcr/omaf100 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30455471 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A case of adult-onset Bartter syndrome with transient paraplegiaShahzaib Siddiqui (22503590)Shayan Ali Irfan (22503593)Shahrukh Ahmed (22503596)Mirza Mehmood Ali Baig (19702599)Jawad Ahmed (5873762)Jawed Iqbal (518263)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsBatter syndromehypokalemiatransient paraplegiayoung adultsalt wastingcase-report<p dir="ltr">Bartter syndrome is a rare inherited renal tubular disorder characterised by metabolic alkalosis, hyperaldosteronism, and salt wasting due to defective salt reabsorption in the ascending loop of Henle. The disease is dominant in the antenatal and neonatal populations and rare in adults. Only a small number of studies present adult-onset Bartter syndrome. We present a case of an adult with transient paraplegia diagnosed with Bartter syndrome. A 22-year-old man presented with sudden bilateral lower limb weakness and cramps for two days, with no history of diarrhoea, vomiting, diuretics, laxatives, or addiction. Biochemical studies revealed hypokalemia, metabolic alkalosis, raised urinary potassium levels and raised serum renin. The potassium replacement therapy was initially ineffective in improving symptoms. The raised urinary calcium to creatinine ratio and normal serum magnesium level were noted. There was no nephrocalcinosis, unlike previously reported cases.</p><h2>Other Information</h2><p dir="ltr">Published in: Oxford Medical Case Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/omcr/omaf100" target="_blank">https://dx.doi.org/10.1093/omcr/omaf100</a></p>2025-07-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1093/omcr/omaf100https://figshare.com/articles/journal_contribution/A_case_of_adult-onset_Bartter_syndrome_with_transient_paraplegia/30455471CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304554712025-07-01T00:00:00Z |
| spellingShingle | A case of adult-onset Bartter syndrome with transient paraplegia Shahzaib Siddiqui (22503590) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Batter syndrome hypokalemia transient paraplegia young adult salt wasting case-report |
| status_str | publishedVersion |
| title | A case of adult-onset Bartter syndrome with transient paraplegia |
| title_full | A case of adult-onset Bartter syndrome with transient paraplegia |
| title_fullStr | A case of adult-onset Bartter syndrome with transient paraplegia |
| title_full_unstemmed | A case of adult-onset Bartter syndrome with transient paraplegia |
| title_short | A case of adult-onset Bartter syndrome with transient paraplegia |
| title_sort | A case of adult-onset Bartter syndrome with transient paraplegia |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Batter syndrome hypokalemia transient paraplegia young adult salt wasting case-report |