The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report
<p>Secondary iron overload is increasingly encountered in chronic kidney disease (CKD) patients because of the frequent use of parenteral iron products, especially in hemodialysis patients. Serum ferritin has been commonly used to monitor iron overload in these patients; however, other conditi...
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2021
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| _version_ | 1864513564246540288 |
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| author | Abdulrahman Al-Mashdali (16388474) |
| author2 | Tahiya Alyafei (16388475) Mohamed Yassin (4166515) |
| author2_role | author author |
| author_facet | Abdulrahman Al-Mashdali (16388474) Tahiya Alyafei (16388475) Mohamed Yassin (4166515) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulrahman Al-Mashdali (16388474) Tahiya Alyafei (16388475) Mohamed Yassin (4166515) |
| dc.date.none.fl_str_mv | 2021-07-16T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/jbm.s319591 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Superiority_of_T2_MRI_Over_Serum_Ferritin_in_the_Evaluation_of_Secondary_Iron_Overload_in_a_Chronic_Kidney_Disease_Patient_A_Case_Report/23537790 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology secondary iron overload chronic kidney disease serum ferritin T2*MRI liver iron concentration |
| dc.title.none.fl_str_mv | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Secondary iron overload is increasingly encountered in chronic kidney disease (CKD) patients because of the frequent use of parenteral iron products, especially in hemodialysis patients. Serum ferritin has been commonly used to monitor iron overload in these patients; however, other conditions can be associated with the high serum ferritin, like infections and inflammatory conditions. Currently, T2*MRI of the heart and liver is the preferred investigation for evaluating liver iron concentration (LIC) and cardiac iron concentration, which reflect the state of iron overload. Few studies observe a positive correlation between serum iron and LIC in CKD patients and postulate that serum ferritin exceeding 290 mcg/L should indicate significant iron overload and necessitates further MRI evaluation. However, here, we present a patient with a history of ESRD for which she underwent renal transplantation twice referred to our clinic due to persistent elevation in serum ferritin level (>1000 mcg/L) for several years. T2*MRI of the heart and liver revealed the absence of iron overload. Our objective of this case is to demonstrate the accuracy of T2*MRI over serum ferritin in evaluating iron overload and questioning the positive correlation between serum ferritin and LIC in CKD patients.</p> <h2>Other Information</h2> <p>Published in: Journal of Blood Medicine<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.2147/jbm.s319591" target="_blank">http://dx.doi.org/10.2147/jbm.s319591 </a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8edde6ca7510e27c3ad5f1a6fa8500e1 |
| identifier_str_mv | 10.2147/jbm.s319591 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23537790 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case ReportAbdulrahman Al-Mashdali (16388474)Tahiya Alyafei (16388475)Mohamed Yassin (4166515)Biomedical and clinical sciencesCardiovascular medicine and haematologysecondary iron overloadchronic kidney diseaseserum ferritinT2*MRIliver iron concentration<p>Secondary iron overload is increasingly encountered in chronic kidney disease (CKD) patients because of the frequent use of parenteral iron products, especially in hemodialysis patients. Serum ferritin has been commonly used to monitor iron overload in these patients; however, other conditions can be associated with the high serum ferritin, like infections and inflammatory conditions. Currently, T2*MRI of the heart and liver is the preferred investigation for evaluating liver iron concentration (LIC) and cardiac iron concentration, which reflect the state of iron overload. Few studies observe a positive correlation between serum iron and LIC in CKD patients and postulate that serum ferritin exceeding 290 mcg/L should indicate significant iron overload and necessitates further MRI evaluation. However, here, we present a patient with a history of ESRD for which she underwent renal transplantation twice referred to our clinic due to persistent elevation in serum ferritin level (>1000 mcg/L) for several years. T2*MRI of the heart and liver revealed the absence of iron overload. Our objective of this case is to demonstrate the accuracy of T2*MRI over serum ferritin in evaluating iron overload and questioning the positive correlation between serum ferritin and LIC in CKD patients.</p> <h2>Other Information</h2> <p>Published in: Journal of Blood Medicine<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.2147/jbm.s319591" target="_blank">http://dx.doi.org/10.2147/jbm.s319591 </a></p>2021-07-16T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/jbm.s319591https://figshare.com/articles/journal_contribution/The_Superiority_of_T2_MRI_Over_Serum_Ferritin_in_the_Evaluation_of_Secondary_Iron_Overload_in_a_Chronic_Kidney_Disease_Patient_A_Case_Report/23537790CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/235377902021-07-16T21:00:00Z |
| spellingShingle | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report Abdulrahman Al-Mashdali (16388474) Biomedical and clinical sciences Cardiovascular medicine and haematology secondary iron overload chronic kidney disease serum ferritin T2*MRI liver iron concentration |
| status_str | publishedVersion |
| title | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| title_full | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| title_fullStr | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| title_full_unstemmed | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| title_short | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| title_sort | The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology secondary iron overload chronic kidney disease serum ferritin T2*MRI liver iron concentration |