Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits
<p dir="ltr">In recent years, the genetic testing and selection of IVF embryos, known as preimplantation genetic testing (PGT), has gained much traction in clinical assisted reproduction for preventing transmission of genetic defects. However, a more recent ethically and morally cont...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2023
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513530568376320 |
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| author | A. H. B. Chin (17787767) |
| author2 | Q. Al-Balas (17787770) M. F. Ahmad (17787773) N. Alsomali (17787776) M. Ghaly (17787779) |
| author2_role | author author author author |
| author_facet | A. H. B. Chin (17787767) Q. Al-Balas (17787770) M. F. Ahmad (17787773) N. Alsomali (17787776) M. Ghaly (17787779) |
| author_role | author |
| dc.creator.none.fl_str_mv | A. H. B. Chin (17787767) Q. Al-Balas (17787770) M. F. Ahmad (17787773) N. Alsomali (17787776) M. Ghaly (17787779) |
| dc.date.none.fl_str_mv | 2023-12-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11673-023-10293-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Islamic_Perspectives_on_Polygenic_Testing_and_Selection_of_IVF_Embryos_PGT-P_for_Optimal_Intelligence_and_Other_Non_Disease-Related_Socially_Desirable_Traits/24998273 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Law and legal studies Law in context Philosophy and religious studies Applied ethics Religious studies Fatwa Islam Muslims Polygenic Risk Scores Preimplantation genetic testing |
| dc.title.none.fl_str_mv | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In recent years, the genetic testing and selection of IVF embryos, known as preimplantation genetic testing (PGT), has gained much traction in clinical assisted reproduction for preventing transmission of genetic defects. However, a more recent ethically and morally controversial development in PGT is its possible use in selecting IVF embryos for optimal intelligence quotient (IQ) and other non–disease-related socially desirable traits, such as tallness, fair complexion, athletic ability, and eye and hair colour, based on polygenic risk scores (PRS), in what is referred to as PGT-P. Artificial intelligence (AI) and machine learning–based analysis of big data sets collated from genome sequencing of specific human ethnic populations can be used to estimate an individual embryo’s likelihood of developing such multifactorial traits by analysing the combination of specific genetic variants within its genome. Superficially, this technique appears compliant with Islamic principles and ethics. Because there is no modification of the human genome, there is no tampering with Allah’s creation (taghyīr khalq Allah). Nevertheless, a more critical analysis based on the five maxims of Islamic jurisprudence (qawa'id fiqhiyyah) that are often utilized in discourses on Islamic bioethics, namely qaṣd (intention), yaqın̄ (certainty), ḍarar (injury), ḍarūra (necessity), and `urf (custom), would instead reveal some major ethical and moral flaws of this new medical technology in the selection of non–disease-related socially desirable traits, and its non-compliance with the spirit and essence of Islamic law (shariah). Muslim scholars, jurists, doctors, and biomedical scientists should debate this further and issue a fatwa on this new medical technology platform.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Bioethical Inquiry<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11673-023-10293-0" target="_blank">https://dx.doi.org/10.1007/s11673-023-10293-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8f70b2d1184183bffdf039ceceeb6a73 |
| identifier_str_mv | 10.1007/s11673-023-10293-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24998273 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable TraitsA. H. B. Chin (17787767)Q. Al-Balas (17787770)M. F. Ahmad (17787773)N. Alsomali (17787776)M. Ghaly (17787779)Health sciencesLaw and legal studiesLaw in contextPhilosophy and religious studiesApplied ethicsReligious studiesFatwaIslamMuslimsPolygenic Risk ScoresPreimplantation genetic testing<p dir="ltr">In recent years, the genetic testing and selection of IVF embryos, known as preimplantation genetic testing (PGT), has gained much traction in clinical assisted reproduction for preventing transmission of genetic defects. However, a more recent ethically and morally controversial development in PGT is its possible use in selecting IVF embryos for optimal intelligence quotient (IQ) and other non–disease-related socially desirable traits, such as tallness, fair complexion, athletic ability, and eye and hair colour, based on polygenic risk scores (PRS), in what is referred to as PGT-P. Artificial intelligence (AI) and machine learning–based analysis of big data sets collated from genome sequencing of specific human ethnic populations can be used to estimate an individual embryo’s likelihood of developing such multifactorial traits by analysing the combination of specific genetic variants within its genome. Superficially, this technique appears compliant with Islamic principles and ethics. Because there is no modification of the human genome, there is no tampering with Allah’s creation (taghyīr khalq Allah). Nevertheless, a more critical analysis based on the five maxims of Islamic jurisprudence (qawa'id fiqhiyyah) that are often utilized in discourses on Islamic bioethics, namely qaṣd (intention), yaqın̄ (certainty), ḍarar (injury), ḍarūra (necessity), and `urf (custom), would instead reveal some major ethical and moral flaws of this new medical technology in the selection of non–disease-related socially desirable traits, and its non-compliance with the spirit and essence of Islamic law (shariah). Muslim scholars, jurists, doctors, and biomedical scientists should debate this further and issue a fatwa on this new medical technology platform.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Bioethical Inquiry<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11673-023-10293-0" target="_blank">https://dx.doi.org/10.1007/s11673-023-10293-0</a></p>2023-12-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11673-023-10293-0https://figshare.com/articles/journal_contribution/Islamic_Perspectives_on_Polygenic_Testing_and_Selection_of_IVF_Embryos_PGT-P_for_Optimal_Intelligence_and_Other_Non_Disease-Related_Socially_Desirable_Traits/24998273CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249982732023-12-04T03:00:00Z |
| spellingShingle | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits A. H. B. Chin (17787767) Health sciences Law and legal studies Law in context Philosophy and religious studies Applied ethics Religious studies Fatwa Islam Muslims Polygenic Risk Scores Preimplantation genetic testing |
| status_str | publishedVersion |
| title | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| title_full | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| title_fullStr | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| title_full_unstemmed | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| title_short | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| title_sort | Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits |
| topic | Health sciences Law and legal studies Law in context Philosophy and religious studies Applied ethics Religious studies Fatwa Islam Muslims Polygenic Risk Scores Preimplantation genetic testing |