Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions
<div><p>This study aimed at characterizing herpes simplex virus type 1 (HSV-1) epidemiology in the Middle East and North Africa (MENA). HSV-1 records were systematically reviewed. Findings were reported following the PRISMA guidelines. Random-effects meta-analyses were implemented to est...
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2019
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| _version_ | 1864513514088955904 |
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| author | Sonia Chaabane (3574202) |
| author2 | Manale Harfouche (4557211) Hiam Chemaitelly (439114) Guido Schwarzer (138791) Laith J. Abu-Raddad (9262524) |
| author2_role | author author author author |
| author_facet | Sonia Chaabane (3574202) Manale Harfouche (4557211) Hiam Chemaitelly (439114) Guido Schwarzer (138791) Laith J. Abu-Raddad (9262524) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sonia Chaabane (3574202) Manale Harfouche (4557211) Hiam Chemaitelly (439114) Guido Schwarzer (138791) Laith J. Abu-Raddad (9262524) |
| dc.date.none.fl_str_mv | 2019-02-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-018-37833-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Herpes_simplex_virus_type_1_epidemiology_in_the_Middle_East_and_North_Africa_systematic_review_meta-analyses_and_meta-regressions/25904362 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Epidemiology Mathematical sciences Statistics Epidemiology Middle East and North Africa (MENA) Seroprevalence Systematic review PRISMA guidelines Meta-analysis Meta-regressions |
| dc.title.none.fl_str_mv | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>This study aimed at characterizing herpes simplex virus type 1 (HSV-1) epidemiology in the Middle East and North Africa (MENA). HSV-1 records were systematically reviewed. Findings were reported following the PRISMA guidelines. Random-effects meta-analyses were implemented to estimate pooled mean HSV-1 seroprevalence. Random-effects meta-regressions were conducted to identify predictors of higher seroprevalence. Thirty-nine overall seroprevalence measures yielding 85 stratified measures were identified and included in the analyses. Pooled mean seroprevalence was 65.2% (95% CI: 53.6–76.1%) in children, and 91.5% (95% CI: 89.4–93.5%) in adults. By age group, seroprevalence was lowest at 60.5% (95% CI: 48.1–72.3%) in <10 years old, followed by 85.6% (95% CI: 80.5–90.1%) in 10–19 years old, 90.7% (95% CI: 84.7–95.5%) in 20–29 years old, and 94.3% (95% CI: 89.5–97.9%) in ≥30 years old. Age was the strongest predictor of seroprevalence explaining 44.3% of the variation. Assay type, sex, population type, year of data collection, year of publication, sample size, and sampling method were not significantly associated with seroprevalence. The aprioriconsidered factors explained 48.6% of the variation in seroprevalence. HSV-1 seroprevalence persists at high levels in MENA with most infections acquired in childhood. There is no evidence for declines in seroprevalence despite improving socio-economic conditions.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-018-37833-8" target="_blank">https://dx.doi.org/10.1038/s41598-018-37833-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8fa0f9924fc3d5efe5c1b5f062090871 |
| identifier_str_mv | 10.1038/s41598-018-37833-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25904362 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressionsSonia Chaabane (3574202)Manale Harfouche (4557211)Hiam Chemaitelly (439114)Guido Schwarzer (138791)Laith J. Abu-Raddad (9262524)Health sciencesEpidemiologyMathematical sciencesStatisticsEpidemiologyMiddle East and North Africa (MENA)SeroprevalenceSystematic reviewPRISMA guidelinesMeta-analysisMeta-regressions<div><p>This study aimed at characterizing herpes simplex virus type 1 (HSV-1) epidemiology in the Middle East and North Africa (MENA). HSV-1 records were systematically reviewed. Findings were reported following the PRISMA guidelines. Random-effects meta-analyses were implemented to estimate pooled mean HSV-1 seroprevalence. Random-effects meta-regressions were conducted to identify predictors of higher seroprevalence. Thirty-nine overall seroprevalence measures yielding 85 stratified measures were identified and included in the analyses. Pooled mean seroprevalence was 65.2% (95% CI: 53.6–76.1%) in children, and 91.5% (95% CI: 89.4–93.5%) in adults. By age group, seroprevalence was lowest at 60.5% (95% CI: 48.1–72.3%) in <10 years old, followed by 85.6% (95% CI: 80.5–90.1%) in 10–19 years old, 90.7% (95% CI: 84.7–95.5%) in 20–29 years old, and 94.3% (95% CI: 89.5–97.9%) in ≥30 years old. Age was the strongest predictor of seroprevalence explaining 44.3% of the variation. Assay type, sex, population type, year of data collection, year of publication, sample size, and sampling method were not significantly associated with seroprevalence. The aprioriconsidered factors explained 48.6% of the variation in seroprevalence. HSV-1 seroprevalence persists at high levels in MENA with most infections acquired in childhood. There is no evidence for declines in seroprevalence despite improving socio-economic conditions.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-018-37833-8" target="_blank">https://dx.doi.org/10.1038/s41598-018-37833-8</a></p>2019-02-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-018-37833-8https://figshare.com/articles/journal_contribution/Herpes_simplex_virus_type_1_epidemiology_in_the_Middle_East_and_North_Africa_systematic_review_meta-analyses_and_meta-regressions/25904362CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259043622019-02-04T03:00:00Z |
| spellingShingle | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions Sonia Chaabane (3574202) Health sciences Epidemiology Mathematical sciences Statistics Epidemiology Middle East and North Africa (MENA) Seroprevalence Systematic review PRISMA guidelines Meta-analysis Meta-regressions |
| status_str | publishedVersion |
| title | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| title_full | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| title_fullStr | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| title_full_unstemmed | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| title_short | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| title_sort | Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions |
| topic | Health sciences Epidemiology Mathematical sciences Statistics Epidemiology Middle East and North Africa (MENA) Seroprevalence Systematic review PRISMA guidelines Meta-analysis Meta-regressions |