Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

<div><p>Background. Hedgehog (Hh) signaling is essential for osteoblast differentiation of mesenchymal progenitors during endochondral bone formation. However, the critical role of Hh signaling during adult bone remodeling remains to be elucidated. Methods. A Smoothened (SMO) antagonist/...

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Bibliographic Details
Main Author: Nihal AlMuraikhi (6002234) (author)
Other Authors: Nuha Almasoud (18618610) (author), Sarah Binhamdan (18618613) (author), Ghaydaa Younis (18618616) (author), Dalia Ali (6002237) (author), Muthurangan Manikandan (6002243) (author), Radhakrishnan Vishnubalaji (3563306) (author), Muhammad Atteya (6002246) (author), Abdulaziz Siyal (6002249) (author), Musaad Alfayez (3571736) (author), Abdullah Aldahmash (3563300) (author), Moustapha Kassem (101848) (author), Nehad M. Alajez (7397276) (author)
Published: 2019
Subjects:
Biomedical and clinical sciences
Clinical sciences
Hedgehog signaling
Osteoblast differentiation
Smoothened antagonist
BMS-833923
Skeletal tissue development
Mesenchymal stem cells
Bone remodeling
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