Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

<div><p>The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	William J. Young (18426897) (author)
مؤلفون آخرون:	Najim Lahrouchi (18426900) (author), Aaron Isaacs (174648) (author), ThuyVy Duong (18426903) (author), Luisa Foco (43249) (author), Farah Ahmed (1388388) (author), Jennifer A. Brody (7743146) (author), Reem Salman (16009257) (author), Raymond Noordam (333224) (author), Jan-Walter Benjamins (18426906) (author), Jeffrey Haessler (169224) (author), Leo-Pekka Lyytikäinen (144253) (author), Linda Repetto (11285123) (author), Maria Pina Concas (12643515) (author), Marten E. van den Berg (3921611) (author), Stefan Weiss (1474864) (author), Antoine R. Baldassari (8578587) (author), Traci M. Bartz (3944510) (author), James P. Cook (7643396) (author), Daniel S. Evans (8182770) (author), Rebecca Freudling (18426909) (author), Oliver Hines (11901945) (author), Jonas L. Isaksen (4433593) (author), Honghuang Lin (560598) (author), Hao Mei (73778) (author), Arden Moscati (8209134) (author), Martina Müller-Nurasyid (193464) (author), Casia Nursyifa (18426912) (author), Yong Qian (2377) (author), Anne Richmond (5854361) (author), Carolina Roselli (3097968) (author), Kathleen A. Ryan (9761333) (author), Eduardo Tarazona-Santos (145092) (author), Sébastien Thériault (11965445) (author), Stefan van Duijvenboden (7116386) (author), Helen R. Warren (5410760) (author), Jie Yao (1440151) (author), Dania Raza (18426915) (author), Stefanie Aeschbacher (3164868) (author), Gustav Ahlberg (5494895) (author), Alvaro Alonso (211735) (author), Laura Andreasen (5494892) (author), Joshua C. Bis (7692986) (author), Eric Boerwinkle (36288) (author), Archie Campbell (669891) (author), Eulalia Catamo (11285099) (author), Massimiliano Cocca (528468) (author), Michael J. Cutler (11604855) (author), Dawood Darbar (181657) (author), Alessandro De Grandi (76509) (author), Antonio De Luca (9038661) (author), Jun Ding (80820) (author), Christina Ellervik (3823540) (author), Patrick T. Ellinor (7743158) (author), Stephan B. Felix (112722) (author), Philippe Froguel (2247) (author), Christian Fuchsberger (76512) (author), Martin Gögele (76513) (author), Claus Graff (11285182) (author), Mariaelisa Graff (802540) (author), Xiuqing Guo (73591) (author), Torben Hansen (140523) (author), Susan R. Heckbert (7634165) (author), Paul L. Huang (7743164) (author), Heikki V. Huikuri (11068202) (author), Nina Hutri-Kähönen (186365) (author), M. Arfan Ikram (135636) (author), Rebecca D. Jackson (7802564) (author), Juhani Junttila (8616510) (author), Maryam Kavousi (524142) (author), Jan A. Kors (7464284) (author), Thiago P. Leal (5015396) (author), Rozenn N. Lemaitre (8967638) (author), Henry J. Lin (6894089) (author), Lars Lind (88400) (author), Allan Linneberg (139773) (author), Simin Liu (11987) (author), Peter W. MacFarlane (18426918) (author), Massimo Mangino (87550) (author), Thomas Meitinger (26605) (author), Massimo Mezzavilla (535235) (author), Pashupati P. Mishra (6642206) (author), Rebecca N. Mitchell (18426921) (author), Nina Mononen (186361) (author), May E. Montasser (12109907) (author), Alanna C. Morrison (7634126) (author), Matthias Nauck (112743) (author), Victor Nauffal (3913075) (author), Pau Navarro (160568) (author), Kjell Nikus (819433) (author), Guillaume Pare (3486221) (author), Kristen K. Patton (18426924) (author), Giulia Pelliccione (18426927) (author), Alan Pittman (4569346) (author), David J. Porteous (107720) (author), Peter P. Pramstaller (7656497) (author), Michael H. Preuss (15222119) (author), Olli T. Raitakari (7588757) (author), Alexander P. Reiner (8174154) (author), Antonio Luiz P. Ribeiro (4033124) (author), Kenneth M. Rice (9640692) (author), Lorenz Risch (430248) (author), David Schlessinger (2399) (author), Ulrich Schotten (5564384) (author), Claudia Schurmann (112694) (author), Xia Shen (145341) (author), M. Benjamin Shoemaker (4389976) (author), Gianfranco Sinagra (290352) (author), Moritz F. Sinner (7743176) (author), Elsayed Z. Soliman (7743179) (author), Monika Stoll (77524) (author), Konstantin Strauch (73658) (author), Kirill Tarasov (481060) (author), Kent D. Taylor (7743188) (author), Andrew Tinker (477693) (author), Stella Trompet (174901) (author), André Uitterlinden (150139) (author), Uwe Völker (112748) (author), Henry Völzke (64286) (author), Melanie Waldenberger (236985) (author), Lu-Chen Weng (211804) (author), Eric A. Whitsel (7370528) (author), James G. Wilson (7218929) (author), Christy L. Avery (8207355) (author), David Conen (191914) (author), Adolfo Correa (610800) (author), Francesco Cucca (145742) (author), Marcus Dörr (112711) (author), Sina A. Gharib (63265) (author), Giorgia Girotto (149894) (author), Niels Grarup (154019) (author), Caroline Hayward (149856) (author), Yalda Jamshidi (262159) (author), Marjo-Riitta Järvelin (2141947) (author), J. Wouter Jukema (6834398) (author), Stefan Kääb (244969) (author), Mika Kähönen (131499) (author), Jørgen K. Kanters (7743167) (author), Charles Kooperberg (18693) (author), Terho Lehtimäki (49739) (author), Maria Fernanda Lima-Costa (7232726) (author), Yongmei Liu (104713) (author), Ruth J. F. Loos (6733301) (author), Steven A. Lubitz (7743194) (author), Dennis O. Mook-Kanamori (148319) (author), Andrew P. Morris (6733298) (author), Jeffrey R. O’Connell (11068030) (author), Morten Salling Olesen (10272920) (author), Michele Orini (3097818) (author), Sandosh Padmanabhan (238533) (author), Cristian Pattaro (65825) (author), Annette Peters (62601) (author), Bruce M. Psaty (7634144) (author), Jerome I. Rotter (7634114) (author), Bruno Stricker (3529307) (author), Pim van der Harst (65060) (author), Cornelia M. van Duijn (7692962) (author), Niek Verweij (128858) (author), James F. Wilson (7638917) (author), Dan E. Arking (7588586) (author), Julia Ramirez (2614513) (author), Pier D. Lambiase (10163594) (author), Nona Sotoodehnia (143373) (author), Borbala Mifsud (3907267) (author), Christopher Newton-Cheh (79953) (author), Patricia B. Munroe (7588601) (author)
منشور في:	2022
الموضوعات:	Biological sciences Biochemistry and cell biology Genetics Physical sciences Astronomical sciences QT interval Electrocardiographic measure Ventricular depolarization Ventricular repolarization QRS duration JT interval
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

_version_	1864513518612512768
author	William J. Young (18426897)
author2	Najim Lahrouchi (18426900) Aaron Isaacs (174648) ThuyVy Duong (18426903) Luisa Foco (43249) Farah Ahmed (1388388) Jennifer A. Brody (7743146) Reem Salman (16009257) Raymond Noordam (333224) Jan-Walter Benjamins (18426906) Jeffrey Haessler (169224) Leo-Pekka Lyytikäinen (144253) Linda Repetto (11285123) Maria Pina Concas (12643515) Marten E. van den Berg (3921611) Stefan Weiss (1474864) Antoine R. Baldassari (8578587) Traci M. Bartz (3944510) James P. Cook (7643396) Daniel S. Evans (8182770) Rebecca Freudling (18426909) Oliver Hines (11901945) Jonas L. Isaksen (4433593) Honghuang Lin (560598) Hao Mei (73778) Arden Moscati (8209134) Martina Müller-Nurasyid (193464) Casia Nursyifa (18426912) Yong Qian (2377) Anne Richmond (5854361) Carolina Roselli (3097968) Kathleen A. Ryan (9761333) Eduardo Tarazona-Santos (145092) Sébastien Thériault (11965445) Stefan van Duijvenboden (7116386) Helen R. Warren (5410760) Jie Yao (1440151) Dania Raza (18426915) Stefanie Aeschbacher (3164868) Gustav Ahlberg (5494895) Alvaro Alonso (211735) Laura Andreasen (5494892) Joshua C. Bis (7692986) Eric Boerwinkle (36288) Archie Campbell (669891) Eulalia Catamo (11285099) Massimiliano Cocca (528468) Michael J. Cutler (11604855) Dawood Darbar (181657) Alessandro De Grandi (76509) Antonio De Luca (9038661) Jun Ding (80820) Christina Ellervik (3823540) Patrick T. Ellinor (7743158) Stephan B. Felix (112722) Philippe Froguel (2247) Christian Fuchsberger (76512) Martin Gögele (76513) Claus Graff (11285182) Mariaelisa Graff (802540) Xiuqing Guo (73591) Torben Hansen (140523) Susan R. Heckbert (7634165) Paul L. Huang (7743164) Heikki V. Huikuri (11068202) Nina Hutri-Kähönen (186365) M. Arfan Ikram (135636) Rebecca D. Jackson (7802564) Juhani Junttila (8616510) Maryam Kavousi (524142) Jan A. Kors (7464284) Thiago P. Leal (5015396) Rozenn N. Lemaitre (8967638) Henry J. Lin (6894089) Lars Lind (88400) Allan Linneberg (139773) Simin Liu (11987) Peter W. MacFarlane (18426918) Massimo Mangino (87550) Thomas Meitinger (26605) Massimo Mezzavilla (535235) Pashupati P. Mishra (6642206) Rebecca N. Mitchell (18426921) Nina Mononen (186361) May E. Montasser (12109907) Alanna C. Morrison (7634126) Matthias Nauck (112743) Victor Nauffal (3913075) Pau Navarro (160568) Kjell Nikus (819433) Guillaume Pare (3486221) Kristen K. Patton (18426924) Giulia Pelliccione (18426927) Alan Pittman (4569346) David J. Porteous (107720) Peter P. Pramstaller (7656497) Michael H. Preuss (15222119) Olli T. Raitakari (7588757) Alexander P. Reiner (8174154) Antonio Luiz P. Ribeiro (4033124) Kenneth M. Rice (9640692) Lorenz Risch (430248) David Schlessinger (2399) Ulrich Schotten (5564384) Claudia Schurmann (112694) Xia Shen (145341) M. Benjamin Shoemaker (4389976) Gianfranco Sinagra (290352) Moritz F. Sinner (7743176) Elsayed Z. Soliman (7743179) Monika Stoll (77524) Konstantin Strauch (73658) Kirill Tarasov (481060) Kent D. Taylor (7743188) Andrew Tinker (477693) Stella Trompet (174901) André Uitterlinden (150139) Uwe Völker (112748) Henry Völzke (64286) Melanie Waldenberger (236985) Lu-Chen Weng (211804) Eric A. Whitsel (7370528) James G. Wilson (7218929) Christy L. Avery (8207355) David Conen (191914) Adolfo Correa (610800) Francesco Cucca (145742) Marcus Dörr (112711) Sina A. Gharib (63265) Giorgia Girotto (149894) Niels Grarup (154019) Caroline Hayward (149856) Yalda Jamshidi (262159) Marjo-Riitta Järvelin (2141947) J. Wouter Jukema (6834398) Stefan Kääb (244969) Mika Kähönen (131499) Jørgen K. Kanters (7743167) Charles Kooperberg (18693) Terho Lehtimäki (49739) Maria Fernanda Lima-Costa (7232726) Yongmei Liu (104713) Ruth J. F. Loos (6733301) Steven A. Lubitz (7743194) Dennis O. Mook-Kanamori (148319) Andrew P. Morris (6733298) Jeffrey R. O’Connell (11068030) Morten Salling Olesen (10272920) Michele Orini (3097818) Sandosh Padmanabhan (238533) Cristian Pattaro (65825) Annette Peters (62601) Bruce M. Psaty (7634144) Jerome I. Rotter (7634114) Bruno Stricker (3529307) Pim van der Harst (65060) Cornelia M. van Duijn (7692962) Niek Verweij (128858) James F. Wilson (7638917) Dan E. Arking (7588586) Julia Ramirez (2614513) Pier D. Lambiase (10163594) Nona Sotoodehnia (143373) Borbala Mifsud (3907267) Christopher Newton-Cheh (79953) Patricia B. Munroe (7588601)
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
author_facet	William J. Young (18426897) Najim Lahrouchi (18426900) Aaron Isaacs (174648) ThuyVy Duong (18426903) Luisa Foco (43249) Farah Ahmed (1388388) Jennifer A. Brody (7743146) Reem Salman (16009257) Raymond Noordam (333224) Jan-Walter Benjamins (18426906) Jeffrey Haessler (169224) Leo-Pekka Lyytikäinen (144253) Linda Repetto (11285123) Maria Pina Concas (12643515) Marten E. van den Berg (3921611) Stefan Weiss (1474864) Antoine R. Baldassari (8578587) Traci M. Bartz (3944510) James P. Cook (7643396) Daniel S. Evans (8182770) Rebecca Freudling (18426909) Oliver Hines (11901945) Jonas L. Isaksen (4433593) Honghuang Lin (560598) Hao Mei (73778) Arden Moscati (8209134) Martina Müller-Nurasyid (193464) Casia Nursyifa (18426912) Yong Qian (2377) Anne Richmond (5854361) Carolina Roselli (3097968) Kathleen A. Ryan (9761333) Eduardo Tarazona-Santos (145092) Sébastien Thériault (11965445) Stefan van Duijvenboden (7116386) Helen R. Warren (5410760) Jie Yao (1440151) Dania Raza (18426915) Stefanie Aeschbacher (3164868) Gustav Ahlberg (5494895) Alvaro Alonso (211735) Laura Andreasen (5494892) Joshua C. Bis (7692986) Eric Boerwinkle (36288) Archie Campbell (669891) Eulalia Catamo (11285099) Massimiliano Cocca (528468) Michael J. Cutler (11604855) Dawood Darbar (181657) Alessandro De Grandi (76509) Antonio De Luca (9038661) Jun Ding (80820) Christina Ellervik (3823540) Patrick T. Ellinor (7743158) Stephan B. Felix (112722) Philippe Froguel (2247) Christian Fuchsberger (76512) Martin Gögele (76513) Claus Graff (11285182) Mariaelisa Graff (802540) Xiuqing Guo (73591) Torben Hansen (140523) Susan R. Heckbert (7634165) Paul L. Huang (7743164) Heikki V. Huikuri (11068202) Nina Hutri-Kähönen (186365) M. Arfan Ikram (135636) Rebecca D. Jackson (7802564) Juhani Junttila (8616510) Maryam Kavousi (524142) Jan A. Kors (7464284) Thiago P. Leal (5015396) Rozenn N. Lemaitre (8967638) Henry J. Lin (6894089) Lars Lind (88400) Allan Linneberg (139773) Simin Liu (11987) Peter W. MacFarlane (18426918) Massimo Mangino (87550) Thomas Meitinger (26605) Massimo Mezzavilla (535235) Pashupati P. Mishra (6642206) Rebecca N. Mitchell (18426921) Nina Mononen (186361) May E. Montasser (12109907) Alanna C. Morrison (7634126) Matthias Nauck (112743) Victor Nauffal (3913075) Pau Navarro (160568) Kjell Nikus (819433) Guillaume Pare (3486221) Kristen K. Patton (18426924) Giulia Pelliccione (18426927) Alan Pittman (4569346) David J. Porteous (107720) Peter P. Pramstaller (7656497) Michael H. Preuss (15222119) Olli T. Raitakari (7588757) Alexander P. Reiner (8174154) Antonio Luiz P. Ribeiro (4033124) Kenneth M. Rice (9640692) Lorenz Risch (430248) David Schlessinger (2399) Ulrich Schotten (5564384) Claudia Schurmann (112694) Xia Shen (145341) M. Benjamin Shoemaker (4389976) Gianfranco Sinagra (290352) Moritz F. Sinner (7743176) Elsayed Z. Soliman (7743179) Monika Stoll (77524) Konstantin Strauch (73658) Kirill Tarasov (481060) Kent D. Taylor (7743188) Andrew Tinker (477693) Stella Trompet (174901) André Uitterlinden (150139) Uwe Völker (112748) Henry Völzke (64286) Melanie Waldenberger (236985) Lu-Chen Weng (211804) Eric A. Whitsel (7370528) James G. Wilson (7218929) Christy L. Avery (8207355) David Conen (191914) Adolfo Correa (610800) Francesco Cucca (145742) Marcus Dörr (112711) Sina A. Gharib (63265) Giorgia Girotto (149894) Niels Grarup (154019) Caroline Hayward (149856) Yalda Jamshidi (262159) Marjo-Riitta Järvelin (2141947) J. Wouter Jukema (6834398) Stefan Kääb (244969) Mika Kähönen (131499) Jørgen K. Kanters (7743167) Charles Kooperberg (18693) Terho Lehtimäki (49739) Maria Fernanda Lima-Costa (7232726) Yongmei Liu (104713) Ruth J. F. Loos (6733301) Steven A. Lubitz (7743194) Dennis O. Mook-Kanamori (148319) Andrew P. Morris (6733298) Jeffrey R. O’Connell (11068030) Morten Salling Olesen (10272920) Michele Orini (3097818) Sandosh Padmanabhan (238533) Cristian Pattaro (65825) Annette Peters (62601) Bruce M. Psaty (7634144) Jerome I. Rotter (7634114) Bruno Stricker (3529307) Pim van der Harst (65060) Cornelia M. van Duijn (7692962) Niek Verweij (128858) James F. Wilson (7638917) Dan E. Arking (7588586) Julia Ramirez (2614513) Pier D. Lambiase (10163594) Nona Sotoodehnia (143373) Borbala Mifsud (3907267) Christopher Newton-Cheh (79953) Patricia B. Munroe (7588601)
author_role	author
dc.creator.none.fl_str_mv	William J. Young (18426897) Najim Lahrouchi (18426900) Aaron Isaacs (174648) ThuyVy Duong (18426903) Luisa Foco (43249) Farah Ahmed (1388388) Jennifer A. Brody (7743146) Reem Salman (16009257) Raymond Noordam (333224) Jan-Walter Benjamins (18426906) Jeffrey Haessler (169224) Leo-Pekka Lyytikäinen (144253) Linda Repetto (11285123) Maria Pina Concas (12643515) Marten E. van den Berg (3921611) Stefan Weiss (1474864) Antoine R. Baldassari (8578587) Traci M. Bartz (3944510) James P. Cook (7643396) Daniel S. Evans (8182770) Rebecca Freudling (18426909) Oliver Hines (11901945) Jonas L. Isaksen (4433593) Honghuang Lin (560598) Hao Mei (73778) Arden Moscati (8209134) Martina Müller-Nurasyid (193464) Casia Nursyifa (18426912) Yong Qian (2377) Anne Richmond (5854361) Carolina Roselli (3097968) Kathleen A. Ryan (9761333) Eduardo Tarazona-Santos (145092) Sébastien Thériault (11965445) Stefan van Duijvenboden (7116386) Helen R. Warren (5410760) Jie Yao (1440151) Dania Raza (18426915) Stefanie Aeschbacher (3164868) Gustav Ahlberg (5494895) Alvaro Alonso (211735) Laura Andreasen (5494892) Joshua C. Bis (7692986) Eric Boerwinkle (36288) Archie Campbell (669891) Eulalia Catamo (11285099) Massimiliano Cocca (528468) Michael J. Cutler (11604855) Dawood Darbar (181657) Alessandro De Grandi (76509) Antonio De Luca (9038661) Jun Ding (80820) Christina Ellervik (3823540) Patrick T. Ellinor (7743158) Stephan B. Felix (112722) Philippe Froguel (2247) Christian Fuchsberger (76512) Martin Gögele (76513) Claus Graff (11285182) Mariaelisa Graff (802540) Xiuqing Guo (73591) Torben Hansen (140523) Susan R. Heckbert (7634165) Paul L. Huang (7743164) Heikki V. Huikuri (11068202) Nina Hutri-Kähönen (186365) M. Arfan Ikram (135636) Rebecca D. Jackson (7802564) Juhani Junttila (8616510) Maryam Kavousi (524142) Jan A. Kors (7464284) Thiago P. Leal (5015396) Rozenn N. Lemaitre (8967638) Henry J. Lin (6894089) Lars Lind (88400) Allan Linneberg (139773) Simin Liu (11987) Peter W. MacFarlane (18426918) Massimo Mangino (87550) Thomas Meitinger (26605) Massimo Mezzavilla (535235) Pashupati P. Mishra (6642206) Rebecca N. Mitchell (18426921) Nina Mononen (186361) May E. Montasser (12109907) Alanna C. Morrison (7634126) Matthias Nauck (112743) Victor Nauffal (3913075) Pau Navarro (160568) Kjell Nikus (819433) Guillaume Pare (3486221) Kristen K. Patton (18426924) Giulia Pelliccione (18426927) Alan Pittman (4569346) David J. Porteous (107720) Peter P. Pramstaller (7656497) Michael H. Preuss (15222119) Olli T. Raitakari (7588757) Alexander P. Reiner (8174154) Antonio Luiz P. Ribeiro (4033124) Kenneth M. Rice (9640692) Lorenz Risch (430248) David Schlessinger (2399) Ulrich Schotten (5564384) Claudia Schurmann (112694) Xia Shen (145341) M. Benjamin Shoemaker (4389976) Gianfranco Sinagra (290352) Moritz F. Sinner (7743176) Elsayed Z. Soliman (7743179) Monika Stoll (77524) Konstantin Strauch (73658) Kirill Tarasov (481060) Kent D. Taylor (7743188) Andrew Tinker (477693) Stella Trompet (174901) André Uitterlinden (150139) Uwe Völker (112748) Henry Völzke (64286) Melanie Waldenberger (236985) Lu-Chen Weng (211804) Eric A. Whitsel (7370528) James G. Wilson (7218929) Christy L. Avery (8207355) David Conen (191914) Adolfo Correa (610800) Francesco Cucca (145742) Marcus Dörr (112711) Sina A. Gharib (63265) Giorgia Girotto (149894) Niels Grarup (154019) Caroline Hayward (149856) Yalda Jamshidi (262159) Marjo-Riitta Järvelin (2141947) J. Wouter Jukema (6834398) Stefan Kääb (244969) Mika Kähönen (131499) Jørgen K. Kanters (7743167) Charles Kooperberg (18693) Terho Lehtimäki (49739) Maria Fernanda Lima-Costa (7232726) Yongmei Liu (104713) Ruth J. F. Loos (6733301) Steven A. Lubitz (7743194) Dennis O. Mook-Kanamori (148319) Andrew P. Morris (6733298) Jeffrey R. O’Connell (11068030) Morten Salling Olesen (10272920) Michele Orini (3097818) Sandosh Padmanabhan (238533) Cristian Pattaro (65825) Annette Peters (62601) Bruce M. Psaty (7634144) Jerome I. Rotter (7634114) Bruno Stricker (3529307) Pim van der Harst (65060) Cornelia M. van Duijn (7692962) Niek Verweij (128858) James F. Wilson (7638917) Dan E. Arking (7588586) Julia Ramirez (2614513) Pier D. Lambiase (10163594) Nona Sotoodehnia (143373) Borbala Mifsud (3907267) Christopher Newton-Cheh (79953) Patricia B. Munroe (7588601)
dc.date.none.fl_str_mv	2022-09-01T00:00:00Z
dc.identifier.none.fl_str_mv	10.1038/s41467-022-32821-z
dc.relation.none.fl_str_mv	https://figshare.com/articles/journal_contribution/Genetic_analyses_of_the_electrocardiographic_QT_interval_and_its_components_identify_additional_loci_and_pathways/25671678
dc.rights.none.fl_str_mv	CC BY 4.0 info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Biological sciences Biochemistry and cell biology Genetics Physical sciences Astronomical sciences QT interval Electrocardiographic measure Ventricular depolarization Ventricular repolarization QRS duration JT interval
dc.title.none.fl_str_mv	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
dc.type.none.fl_str_mv	Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal
description	<div><p>The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Nature Communications<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-022-32821-z" target="_blank">https://dx.doi.org/10.1038/s41467-022-32821-z</a></p>
eu_rights_str_mv	openAccess
id	Manara2_90cfe3167d4b7e2cf968823386f4e817
identifier_str_mv	10.1038/s41467-022-32821-z
network_acronym_str	Manara2
network_name_str	Manara2
oai_identifier_str	oai:figshare.com:article/25671678
publishDate	2022
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY 4.0
spelling	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathwaysWilliam J. Young (18426897)Najim Lahrouchi (18426900)Aaron Isaacs (174648)ThuyVy Duong (18426903)Luisa Foco (43249)Farah Ahmed (1388388)Jennifer A. Brody (7743146)Reem Salman (16009257)Raymond Noordam (333224)Jan-Walter Benjamins (18426906)Jeffrey Haessler (169224)Leo-Pekka Lyytikäinen (144253)Linda Repetto (11285123)Maria Pina Concas (12643515)Marten E. van den Berg (3921611)Stefan Weiss (1474864)Antoine R. Baldassari (8578587)Traci M. Bartz (3944510)James P. Cook (7643396)Daniel S. Evans (8182770)Rebecca Freudling (18426909)Oliver Hines (11901945)Jonas L. Isaksen (4433593)Honghuang Lin (560598)Hao Mei (73778)Arden Moscati (8209134)Martina Müller-Nurasyid (193464)Casia Nursyifa (18426912)Yong Qian (2377)Anne Richmond (5854361)Carolina Roselli (3097968)Kathleen A. Ryan (9761333)Eduardo Tarazona-Santos (145092)Sébastien Thériault (11965445)Stefan van Duijvenboden (7116386)Helen R. Warren (5410760)Jie Yao (1440151)Dania Raza (18426915)Stefanie Aeschbacher (3164868)Gustav Ahlberg (5494895)Alvaro Alonso (211735)Laura Andreasen (5494892)Joshua C. Bis (7692986)Eric Boerwinkle (36288)Archie Campbell (669891)Eulalia Catamo (11285099)Massimiliano Cocca (528468)Michael J. Cutler (11604855)Dawood Darbar (181657)Alessandro De Grandi (76509)Antonio De Luca (9038661)Jun Ding (80820)Christina Ellervik (3823540)Patrick T. Ellinor (7743158)Stephan B. Felix (112722)Philippe Froguel (2247)Christian Fuchsberger (76512)Martin Gögele (76513)Claus Graff (11285182)Mariaelisa Graff (802540)Xiuqing Guo (73591)Torben Hansen (140523)Susan R. Heckbert (7634165)Paul L. Huang (7743164)Heikki V. Huikuri (11068202)Nina Hutri-Kähönen (186365)M. Arfan Ikram (135636)Rebecca D. Jackson (7802564)Juhani Junttila (8616510)Maryam Kavousi (524142)Jan A. Kors (7464284)Thiago P. Leal (5015396)Rozenn N. Lemaitre (8967638)Henry J. Lin (6894089)Lars Lind (88400)Allan Linneberg (139773)Simin Liu (11987)Peter W. MacFarlane (18426918)Massimo Mangino (87550)Thomas Meitinger (26605)Massimo Mezzavilla (535235)Pashupati P. Mishra (6642206)Rebecca N. Mitchell (18426921)Nina Mononen (186361)May E. Montasser (12109907)Alanna C. Morrison (7634126)Matthias Nauck (112743)Victor Nauffal (3913075)Pau Navarro (160568)Kjell Nikus (819433)Guillaume Pare (3486221)Kristen K. Patton (18426924)Giulia Pelliccione (18426927)Alan Pittman (4569346)David J. Porteous (107720)Peter P. Pramstaller (7656497)Michael H. Preuss (15222119)Olli T. Raitakari (7588757)Alexander P. Reiner (8174154)Antonio Luiz P. Ribeiro (4033124)Kenneth M. Rice (9640692)Lorenz Risch (430248)David Schlessinger (2399)Ulrich Schotten (5564384)Claudia Schurmann (112694)Xia Shen (145341)M. Benjamin Shoemaker (4389976)Gianfranco Sinagra (290352)Moritz F. Sinner (7743176)Elsayed Z. Soliman (7743179)Monika Stoll (77524)Konstantin Strauch (73658)Kirill Tarasov (481060)Kent D. Taylor (7743188)Andrew Tinker (477693)Stella Trompet (174901)André Uitterlinden (150139)Uwe Völker (112748)Henry Völzke (64286)Melanie Waldenberger (236985)Lu-Chen Weng (211804)Eric A. Whitsel (7370528)James G. Wilson (7218929)Christy L. Avery (8207355)David Conen (191914)Adolfo Correa (610800)Francesco Cucca (145742)Marcus Dörr (112711)Sina A. Gharib (63265)Giorgia Girotto (149894)Niels Grarup (154019)Caroline Hayward (149856)Yalda Jamshidi (262159)Marjo-Riitta Järvelin (2141947)J. Wouter Jukema (6834398)Stefan Kääb (244969)Mika Kähönen (131499)Jørgen K. Kanters (7743167)Charles Kooperberg (18693)Terho Lehtimäki (49739)Maria Fernanda Lima-Costa (7232726)Yongmei Liu (104713)Ruth J. F. Loos (6733301)Steven A. Lubitz (7743194)Dennis O. Mook-Kanamori (148319)Andrew P. Morris (6733298)Jeffrey R. O’Connell (11068030)Morten Salling Olesen (10272920)Michele Orini (3097818)Sandosh Padmanabhan (238533)Cristian Pattaro (65825)Annette Peters (62601)Bruce M. Psaty (7634144)Jerome I. Rotter (7634114)Bruno Stricker (3529307)Pim van der Harst (65060)Cornelia M. van Duijn (7692962)Niek Verweij (128858)James F. Wilson (7638917)Dan E. Arking (7588586)Julia Ramirez (2614513)Pier D. Lambiase (10163594)Nona Sotoodehnia (143373)Borbala Mifsud (3907267)Christopher Newton-Cheh (79953)Patricia B. Munroe (7588601)Biological sciencesBiochemistry and cell biologyGeneticsPhysical sciencesAstronomical sciencesQT intervalElectrocardiographic measureVentricular depolarizationVentricular repolarizationQRS durationJT interval<div><p>The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Nature Communications<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-022-32821-z" target="_blank">https://dx.doi.org/10.1038/s41467-022-32821-z</a></p>2022-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41467-022-32821-zhttps://figshare.com/articles/journal_contribution/Genetic_analyses_of_the_electrocardiographic_QT_interval_and_its_components_identify_additional_loci_and_pathways/25671678CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256716782022-09-01T00:00:00Z
spellingShingle	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways William J. Young (18426897) Biological sciences Biochemistry and cell biology Genetics Physical sciences Astronomical sciences QT interval Electrocardiographic measure Ventricular depolarization Ventricular repolarization QRS duration JT interval
status_str	publishedVersion
title	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
title_full	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
title_fullStr	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
title_full_unstemmed	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
title_short	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
title_sort	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
topic	Biological sciences Biochemistry and cell biology Genetics Physical sciences Astronomical sciences QT interval Electrocardiographic measure Ventricular depolarization Ventricular repolarization QRS duration JT interval

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

مواد مشابهة