Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study
<h3>Background </h3><p dir="ltr">Polypharmacy has become a global public health concern particularly in the elderly population. The elderly population is the most susceptible to the negative effects of polypharmacy due to their altered pharmacokinetics and decreased drug...
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2020
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| _version_ | 1864513539562012672 |
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| author | Ayman Al-Dahshan (8962568) |
| author2 | Noora Al-Kubiasi (8962571) Manal Al-Zaidan (8962574) Wael Saeed (8962577) Vahe Kehyayan (8962580) Iheb Bougmiza (8962583) |
| author2_role | author author author author author |
| author_facet | Ayman Al-Dahshan (8962568) Noora Al-Kubiasi (8962571) Manal Al-Zaidan (8962574) Wael Saeed (8962577) Vahe Kehyayan (8962580) Iheb Bougmiza (8962583) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ayman Al-Dahshan (8962568) Noora Al-Kubiasi (8962571) Manal Al-Zaidan (8962574) Wael Saeed (8962577) Vahe Kehyayan (8962580) Iheb Bougmiza (8962583) |
| dc.date.none.fl_str_mv | 2020-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0234386 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Prevalence_of_polypharmacy_and_the_association_with_non-communicable_diseases_in_Qatari_elderly_patients_attending_primary_healthcare_centers_A_cross-sectional_study/30177010 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Pharmacology and pharmaceutical sciences Health sciences Public health Geriatric care Noncommunicable diseases Cardiovascular diseases Diabetes mellitus Hypertension Cardiology Asthma Body mass index |
| dc.title.none.fl_str_mv | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background </h3><p dir="ltr">Polypharmacy has become a global public health concern particularly in the elderly population. The elderly population is the most susceptible to the negative effects of polypharmacy due to their altered pharmacokinetics and decreased drug clearance. Therefore, polypharmacy can lead to poor health status and higher rates of morbidity and mortality. </p><h3>Objective </h3><p dir="ltr">The objective of this study was to determine the prevalence of polypharmacy (≥ 5 drugs) and its association with non-communicable diseases (NCDs) in elderly (≥65 years) Qatari patients attending Primary Healthcare (PHC) centers in Qatar. </p><h3>Methods </h3><p dir="ltr">A retrospective cross-sectional analysis was conducted using the Electronic Medical Record (EMR) database of all PHC centers in Qatar for six months (April-September 2017). </p><h3>Results </h3><p dir="ltr">Out of 5639 patients screened, 75.5% (95% CI: 74.3–76.6) were exposed to polypharmacy. Females were 1.18 times more likely to have polypharmacy compared to males (95% CI: 1.03–1.34). The multivariate analysis identified having hypertension (AOR 1.71; 95% CI: 1.38–2.13), diabetes (AOR 2.38; 95% CI: 1.97–2.87), dyslipidemia (AOR 1.29; 95% CI: 1.06–1.56), cardiovascular disease (AOR 1.56; 95% CI: 1.25–1.95) and asthma (AOR 1.39; 95% CI: 1.13–1.72) to be independent parameters associated with polypharmacy. Also, the Body Mass Index (BMI) and number of NCDs were found to be significant independent parameters associated with polypharmacy. </p><h3>Conclusions </h3><p dir="ltr">The prevalence of polypharmacy among Qatari elderly attending PHC Centers is very high. Our findings confirm the strong relationship between polypharmacy and BMI, and certain NCDs. Healthcare professionals should be educated about the magnitude of polypharmacy, its negative effects, and its associated factors. Best practice guidelines should be developed for improved medical practice in the prescription of medications for such a vulnerable population.</p><p dir="ltr">Correction: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study <a href="https://doi.org/10.1371/journal.pone.0238343" target="_blank">https://doi.org/10.1371/journal.pone.0238343</a>, published online 24 August 2020.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0234386" target="_blank">https://dx.doi.org/10.1371/journal.pone.0234386</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_90d3d10f50666173a23fee367f42beae |
| identifier_str_mv | 10.1371/journal.pone.0234386 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30177010 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional studyAyman Al-Dahshan (8962568)Noora Al-Kubiasi (8962571)Manal Al-Zaidan (8962574)Wael Saeed (8962577)Vahe Kehyayan (8962580)Iheb Bougmiza (8962583)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesPharmacology and pharmaceutical sciencesHealth sciencesPublic healthGeriatric careNoncommunicable diseasesCardiovascular diseasesDiabetes mellitusHypertensionCardiologyAsthmaBody mass index<h3>Background </h3><p dir="ltr">Polypharmacy has become a global public health concern particularly in the elderly population. The elderly population is the most susceptible to the negative effects of polypharmacy due to their altered pharmacokinetics and decreased drug clearance. Therefore, polypharmacy can lead to poor health status and higher rates of morbidity and mortality. </p><h3>Objective </h3><p dir="ltr">The objective of this study was to determine the prevalence of polypharmacy (≥ 5 drugs) and its association with non-communicable diseases (NCDs) in elderly (≥65 years) Qatari patients attending Primary Healthcare (PHC) centers in Qatar. </p><h3>Methods </h3><p dir="ltr">A retrospective cross-sectional analysis was conducted using the Electronic Medical Record (EMR) database of all PHC centers in Qatar for six months (April-September 2017). </p><h3>Results </h3><p dir="ltr">Out of 5639 patients screened, 75.5% (95% CI: 74.3–76.6) were exposed to polypharmacy. Females were 1.18 times more likely to have polypharmacy compared to males (95% CI: 1.03–1.34). The multivariate analysis identified having hypertension (AOR 1.71; 95% CI: 1.38–2.13), diabetes (AOR 2.38; 95% CI: 1.97–2.87), dyslipidemia (AOR 1.29; 95% CI: 1.06–1.56), cardiovascular disease (AOR 1.56; 95% CI: 1.25–1.95) and asthma (AOR 1.39; 95% CI: 1.13–1.72) to be independent parameters associated with polypharmacy. Also, the Body Mass Index (BMI) and number of NCDs were found to be significant independent parameters associated with polypharmacy. </p><h3>Conclusions </h3><p dir="ltr">The prevalence of polypharmacy among Qatari elderly attending PHC Centers is very high. Our findings confirm the strong relationship between polypharmacy and BMI, and certain NCDs. Healthcare professionals should be educated about the magnitude of polypharmacy, its negative effects, and its associated factors. Best practice guidelines should be developed for improved medical practice in the prescription of medications for such a vulnerable population.</p><p dir="ltr">Correction: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study <a href="https://doi.org/10.1371/journal.pone.0238343" target="_blank">https://doi.org/10.1371/journal.pone.0238343</a>, published online 24 August 2020.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0234386" target="_blank">https://dx.doi.org/10.1371/journal.pone.0234386</a></p>2020-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0234386https://figshare.com/articles/journal_contribution/Prevalence_of_polypharmacy_and_the_association_with_non-communicable_diseases_in_Qatari_elderly_patients_attending_primary_healthcare_centers_A_cross-sectional_study/30177010CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301770102020-06-01T00:00:00Z |
| spellingShingle | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study Ayman Al-Dahshan (8962568) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Pharmacology and pharmaceutical sciences Health sciences Public health Geriatric care Noncommunicable diseases Cardiovascular diseases Diabetes mellitus Hypertension Cardiology Asthma Body mass index |
| status_str | publishedVersion |
| title | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| title_full | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| title_fullStr | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| title_full_unstemmed | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| title_short | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| title_sort | Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Pharmacology and pharmaceutical sciences Health sciences Public health Geriatric care Noncommunicable diseases Cardiovascular diseases Diabetes mellitus Hypertension Cardiology Asthma Body mass index |