Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately?
<h3>Purpose</h3><p dir="ltr">To assess if Diffusion weighted Signal Intensity Ratio (DW-SIR) is a good parameter for differentiating malignant from benign and borderline ovarian lesions. </p><h3>Methods</h3><p dir="ltr">The MRI studies of...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , , , |
| منشور في: |
2025
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إضافة وسم
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| _version_ | 1864513532056305664 |
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| author | Nabil Sherif Mahmood (22501889) |
| author2 | Amal Ahmed Al Rashid (22631471) Sushila Bhupatbhai Ladumor (22631474) Maysa Abdelhafeez Mohamed (22631477) Aalaa Salaheldin Kambal (22631480) Nehal Saloum (18094849) Sara Elaish Mohamed Kheir Mohamed (22631483) Ahmed Hassan Mohamed Abdelmoneim (22631486) Haya Sultan H.S. Al-Merekhi (22631489) Adham Darweesh (22501898) Amal Mohd Hassan Alobadli (22631492) Samir Al Hyassat (14777572) Mohamed Taha Hussein El Sayed (22631495) Afaf Ali Hassan Mohd Al-Ansari (22631498) Rajvir Singh (315457) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Nabil Sherif Mahmood (22501889) Amal Ahmed Al Rashid (22631471) Sushila Bhupatbhai Ladumor (22631474) Maysa Abdelhafeez Mohamed (22631477) Aalaa Salaheldin Kambal (22631480) Nehal Saloum (18094849) Sara Elaish Mohamed Kheir Mohamed (22631483) Ahmed Hassan Mohamed Abdelmoneim (22631486) Haya Sultan H.S. Al-Merekhi (22631489) Adham Darweesh (22501898) Amal Mohd Hassan Alobadli (22631492) Samir Al Hyassat (14777572) Mohamed Taha Hussein El Sayed (22631495) Afaf Ali Hassan Mohd Al-Ansari (22631498) Rajvir Singh (315457) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nabil Sherif Mahmood (22501889) Amal Ahmed Al Rashid (22631471) Sushila Bhupatbhai Ladumor (22631474) Maysa Abdelhafeez Mohamed (22631477) Aalaa Salaheldin Kambal (22631480) Nehal Saloum (18094849) Sara Elaish Mohamed Kheir Mohamed (22631483) Ahmed Hassan Mohamed Abdelmoneim (22631486) Haya Sultan H.S. Al-Merekhi (22631489) Adham Darweesh (22501898) Amal Mohd Hassan Alobadli (22631492) Samir Al Hyassat (14777572) Mohamed Taha Hussein El Sayed (22631495) Afaf Ali Hassan Mohd Al-Ansari (22631498) Rajvir Singh (315457) |
| dc.date.none.fl_str_mv | 2025-10-29T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.crad.2025.107148 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Utility_of_Diffusion_Weighted_Signal_Intensity_Ratio_measurements_for_predicting_malignancy_in_adnexal_mass_lesions_and_its_comparison_with_ORADS_MRI_scoring_Can_an_abbreviated_MRI_protocol_predict_malignancy_accurately_/30636521 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Ovarian MRI Malignancy Diffusion weighted Imaging |
| dc.title.none.fl_str_mv | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">To assess if Diffusion weighted Signal Intensity Ratio (DW-SIR) is a good parameter for differentiating malignant from benign and borderline ovarian lesions. </p><h3>Methods</h3><p dir="ltr">The MRI studies of histopathologically diagnosed cases of ovarian tumors were reviewed by two groups of radiologists, both calculating the DW SIR for individual cases. The correlation between the DW SIR and ORADS scoring was tested statistically and the positive likelihood ratio of ORADS scoring for predicting malignancy when used solely as well as in conjunction with DW-SIR was calculated. </p><h3>Results</h3><p dir="ltr">A total of 184 cases were included, of which 74 cases were Benign/borderline (40%) and 110 cases were malignant (60%). A DW SIR cut off of 0.375 calculated after the first cycle of reading had an accuracy of 68.5% and positive predictive value (PPV) of 73% in predicting malignancy. The PPV for malignancy for each ORADS score increased especially in the ORADS 3 group when the DW SIR cut off was applied. Higher DW SIR values were associated with a bigger ORADS score (p <0.001). A marginal increase in the positive likelihood ratio for malignancy was observed in the combined ORADS 4 and 5 groups upon using the DW-SIR cut off. </p><h3>Conclusion</h3><p dir="ltr">DW-SIR can serve as an adjunctive tool to improve confidence in interpreting intermediate-risk ORADS cases or as a standalone triage tool when contrast MRI is contraindicated, keeping in mind its limitations in sensitivity.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Radiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.crad.2025.107148" target="_blank">https://dx.doi.org/10.1016/j.crad.2025.107148</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9336ffbf721f8eb0aeef79f1f542cca7 |
| identifier_str_mv | 10.1016/j.crad.2025.107148 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30636521 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately?Nabil Sherif Mahmood (22501889)Amal Ahmed Al Rashid (22631471)Sushila Bhupatbhai Ladumor (22631474)Maysa Abdelhafeez Mohamed (22631477)Aalaa Salaheldin Kambal (22631480)Nehal Saloum (18094849)Sara Elaish Mohamed Kheir Mohamed (22631483)Ahmed Hassan Mohamed Abdelmoneim (22631486)Haya Sultan H.S. Al-Merekhi (22631489)Adham Darweesh (22501898)Amal Mohd Hassan Alobadli (22631492)Samir Al Hyassat (14777572)Mohamed Taha Hussein El Sayed (22631495)Afaf Ali Hassan Mohd Al-Ansari (22631498)Rajvir Singh (315457)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisOvarianMRIMalignancyDiffusion weighted Imaging<h3>Purpose</h3><p dir="ltr">To assess if Diffusion weighted Signal Intensity Ratio (DW-SIR) is a good parameter for differentiating malignant from benign and borderline ovarian lesions. </p><h3>Methods</h3><p dir="ltr">The MRI studies of histopathologically diagnosed cases of ovarian tumors were reviewed by two groups of radiologists, both calculating the DW SIR for individual cases. The correlation between the DW SIR and ORADS scoring was tested statistically and the positive likelihood ratio of ORADS scoring for predicting malignancy when used solely as well as in conjunction with DW-SIR was calculated. </p><h3>Results</h3><p dir="ltr">A total of 184 cases were included, of which 74 cases were Benign/borderline (40%) and 110 cases were malignant (60%). A DW SIR cut off of 0.375 calculated after the first cycle of reading had an accuracy of 68.5% and positive predictive value (PPV) of 73% in predicting malignancy. The PPV for malignancy for each ORADS score increased especially in the ORADS 3 group when the DW SIR cut off was applied. Higher DW SIR values were associated with a bigger ORADS score (p <0.001). A marginal increase in the positive likelihood ratio for malignancy was observed in the combined ORADS 4 and 5 groups upon using the DW-SIR cut off. </p><h3>Conclusion</h3><p dir="ltr">DW-SIR can serve as an adjunctive tool to improve confidence in interpreting intermediate-risk ORADS cases or as a standalone triage tool when contrast MRI is contraindicated, keeping in mind its limitations in sensitivity.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Radiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.crad.2025.107148" target="_blank">https://dx.doi.org/10.1016/j.crad.2025.107148</a></p>2025-10-29T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.crad.2025.107148https://figshare.com/articles/journal_contribution/Utility_of_Diffusion_Weighted_Signal_Intensity_Ratio_measurements_for_predicting_malignancy_in_adnexal_mass_lesions_and_its_comparison_with_ORADS_MRI_scoring_Can_an_abbreviated_MRI_protocol_predict_malignancy_accurately_/30636521CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306365212025-10-29T09:00:00Z |
| spellingShingle | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? Nabil Sherif Mahmood (22501889) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Ovarian MRI Malignancy Diffusion weighted Imaging |
| status_str | publishedVersion |
| title | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| title_full | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| title_fullStr | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| title_full_unstemmed | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| title_short | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| title_sort | Utility of Diffusion Weighted Signal Intensity Ratio measurements for predicting malignancy in adnexal mass lesions and its comparison with ORADS MRI scoring – Can an abbreviated MRI protocol predict malignancy accurately? |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Ovarian MRI Malignancy Diffusion weighted Imaging |