Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

<h3>Background</h3><p dir="ltr">Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to featur...

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Bibliographic Details
Main Author: Megan F. Duffy (5713772) (author)
Other Authors: Timothy J. Collier (18614878) (author), Joseph R. Patterson (5713775) (author), Christopher J. Kemp (221372) (author), Kelvin C. Luk (2407042) (author), Malú G. Tansey (8382525) (author), Katrina L. Paumier (14131716) (author), Nicholas M. Kanaan (707720) (author), D. Luke Fischer (14131710) (author), Nicole K. Polinski (10947787) (author), Olivia L. Barth (18628681) (author), Jacob W. Howe (18614875) (author), Nishant N. Vaikath (2901785) (author), Nour K. Majbour (8809316) (author), Omar M. A. El-Agnaf (8809331) (author), Caryl E. Sortwell (14131722) (author)
Published: 2018
Subjects:
Biomedical and clinical sciences
Neurosciences
Neuroinflammation
Parkinson’s disease
Animal models
Synucleinopathy
Microglia
Major-histocompatibility complex-II
Neurodegeneration
Selective vulnerability
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