Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

<h3>Background</h3><p dir="ltr">Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to featur...

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المؤلف الرئيسي:	Megan F. Duffy (5713772) (author)
مؤلفون آخرون:	Timothy J. Collier (18614878) (author), Joseph R. Patterson (5713775) (author), Christopher J. Kemp (221372) (author), Kelvin C. Luk (2407042) (author), Malú G. Tansey (8382525) (author), Katrina L. Paumier (14131716) (author), Nicholas M. Kanaan (707720) (author), D. Luke Fischer (14131710) (author), Nicole K. Polinski (10947787) (author), Olivia L. Barth (18628681) (author), Jacob W. Howe (18614875) (author), Nishant N. Vaikath (2901785) (author), Nour K. Majbour (8809316) (author), Omar M. A. El-Agnaf (8809331) (author), Caryl E. Sortwell (14131722) (author)
منشور في:	2018
الموضوعات:	Biomedical and clinical sciences Neurosciences Neuroinflammation Parkinson’s disease Animal models Synucleinopathy Microglia Major-histocompatibility complex-II Neurodegeneration Selective vulnerability
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

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