Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

<p dir="ltr">Approximately 90% of alpha-synuclein (α-Synuclein) deposited in Lewy bodies is phosphorylated at serine 129 suggesting that the accumulation of phosphorylated α-Synuclein is critical in the pathogenesis of Parkinson’s disease. However, in vivo experiments addressing the...

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Bibliographic Details
Main Author: Mantia Karampetsou (8737815) (author)
Other Authors: Mustafa T. Ardah (4858657) (author), Maria Semitekolou (2938959) (author), Alexia Polissidis (3040905) (author), Martina Samiotaki (438647) (author), Maria Kalomoiri (16874580) (author), Nour Majbour (3528548) (author), Georgina Xanthou (8344188) (author), Omar M. A. El-Agnaf (8809331) (author), Kostas Vekrellis (214282) (author)
Published: 2017
Subjects:
Biomedical and clinical sciences
Neurosciences
Alpha-synuclein (α-Synuclein)
Parkinson’s disease
Phosphorylation
Lewy bodies
Stereotaxic injections
Neurodegeneration
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