Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor
<p dir="ltr">First described in 1995 by Meis-Kindbloom et al. as a variant of fibrosarcoma simulating carcinoma, sclerosing epithelioid fibrosarcoma (SEF) is a malignant soft tissue sarcoma characterized by epithelioid cells in dense sclerotic stroma, frequent immunoreactivity for MU...
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2021
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| _version_ | 1864513566147608576 |
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| author | Khaled A. Murshed (14151927) |
| author2 | Issam Al‐Bozom (14777317) Adham Ammar (14151933) |
| author2_role | author author |
| author_facet | Khaled A. Murshed (14151927) Issam Al‐Bozom (14777317) Adham Ammar (14151933) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khaled A. Murshed (14151927) Issam Al‐Bozom (14777317) Adham Ammar (14151933) |
| dc.date.none.fl_str_mv | 2021-05-28T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/apm.13157 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Sclerosing_epithelioid_fibrosarcoma_in_depth_review_of_a_genetically_heterogeneous_tumor/22258459 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |
| dc.title.none.fl_str_mv | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">First described in 1995 by Meis-Kindbloom et al. as a variant of fibrosarcoma simulating carcinoma, sclerosing epithelioid fibrosarcoma (SEF) is a malignant soft tissue sarcoma characterized by epithelioid cells in dense sclerotic stroma, frequent immunoreactivity for MUC4 and heterogeneous genetic profile with recurrent <i>EWSR1</i> gene rearrangement. It typically affects middle-age adults with a predilection for the lower extremity. It is believed that SEF is closely related to low-grade fibromyxoid sarcoma (LGFMS), both tumors show overlapping features in morphology, immunophenotype, and molecular profile. In this review, we discuss the clinical, morphologic, and immunohistochemical features of SEF with particular emphasis on its molecular diversity and relation to LGFMS.</p><h2>Other Information</h2><p dir="ltr">Published in: APMIS<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/apm.13157" target="_blank">http://dx.doi.org/10.1111/apm.13157</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_93c7f268660c1bb35584335db16e3a6e |
| identifier_str_mv | 10.1111/apm.13157 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258459 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumorKhaled A. Murshed (14151927)Issam Al‐Bozom (14777317)Adham Ammar (14151933)Biomedical and clinical sciencesImmunologyMicrobiology (medical)General MedicineImmunology and AllergyPathology and Forensic Medicine<p dir="ltr">First described in 1995 by Meis-Kindbloom et al. as a variant of fibrosarcoma simulating carcinoma, sclerosing epithelioid fibrosarcoma (SEF) is a malignant soft tissue sarcoma characterized by epithelioid cells in dense sclerotic stroma, frequent immunoreactivity for MUC4 and heterogeneous genetic profile with recurrent <i>EWSR1</i> gene rearrangement. It typically affects middle-age adults with a predilection for the lower extremity. It is believed that SEF is closely related to low-grade fibromyxoid sarcoma (LGFMS), both tumors show overlapping features in morphology, immunophenotype, and molecular profile. In this review, we discuss the clinical, morphologic, and immunohistochemical features of SEF with particular emphasis on its molecular diversity and relation to LGFMS.</p><h2>Other Information</h2><p dir="ltr">Published in: APMIS<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/apm.13157" target="_blank">http://dx.doi.org/10.1111/apm.13157</a></p>2021-05-28T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/apm.13157https://figshare.com/articles/journal_contribution/Sclerosing_epithelioid_fibrosarcoma_in_depth_review_of_a_genetically_heterogeneous_tumor/22258459CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222584592021-05-28T21:00:00Z |
| spellingShingle | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor Khaled A. Murshed (14151927) Biomedical and clinical sciences Immunology Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |
| status_str | publishedVersion |
| title | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| title_full | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| title_fullStr | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| title_full_unstemmed | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| title_short | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| title_sort | Sclerosing epithelioid fibrosarcoma: in‐depth review of a genetically heterogeneous tumor |
| topic | Biomedical and clinical sciences Immunology Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |