The gut-microbiota-brain axis in autism: what Drosophila models can offer?
<div><p>The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2021
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| _version_ | 1864513516684181504 |
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| author | Safa Salim (9186786) |
| author2 | Ayesha Banu (11438825) Amira Alwa (11438828) Swetha B. M. Gowda (11438831) Farhan Mohammad (256409) |
| author2_role | author author author author |
| author_facet | Safa Salim (9186786) Ayesha Banu (11438825) Amira Alwa (11438828) Swetha B. M. Gowda (11438831) Farhan Mohammad (256409) |
| author_role | author |
| dc.creator.none.fl_str_mv | Safa Salim (9186786) Ayesha Banu (11438825) Amira Alwa (11438828) Swetha B. M. Gowda (11438831) Farhan Mohammad (256409) |
| dc.date.none.fl_str_mv | 2021-09-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s11689-021-09378-x |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_gut-microbiota-brain_axis_in_autism_what_Drosophila_models_can_offer_/25771167 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Gut-microbiome-brain axis Autism spectrum disorders Gastrointestinal issues Drosophila |
| dc.title.none.fl_str_mv | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Neurodevelopmental Disorders<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s11689-021-09378-x" target="_blank">https://dx.doi.org/10.1186/s11689-021-09378-x</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9414f02af85f30f8d389cd8a5af85215 |
| identifier_str_mv | 10.1186/s11689-021-09378-x |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25771167 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The gut-microbiota-brain axis in autism: what Drosophila models can offer?Safa Salim (9186786)Ayesha Banu (11438825)Amira Alwa (11438828)Swetha B. M. Gowda (11438831)Farhan Mohammad (256409)Biomedical and clinical sciencesNeurosciencesGut-microbiome-brain axisAutism spectrum disordersGastrointestinal issuesDrosophila<div><p>The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Neurodevelopmental Disorders<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s11689-021-09378-x" target="_blank">https://dx.doi.org/10.1186/s11689-021-09378-x</a></p>2021-09-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s11689-021-09378-xhttps://figshare.com/articles/journal_contribution/The_gut-microbiota-brain_axis_in_autism_what_Drosophila_models_can_offer_/25771167CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257711672021-09-15T03:00:00Z |
| spellingShingle | The gut-microbiota-brain axis in autism: what Drosophila models can offer? Safa Salim (9186786) Biomedical and clinical sciences Neurosciences Gut-microbiome-brain axis Autism spectrum disorders Gastrointestinal issues Drosophila |
| status_str | publishedVersion |
| title | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| title_full | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| title_fullStr | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| title_full_unstemmed | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| title_short | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| title_sort | The gut-microbiota-brain axis in autism: what Drosophila models can offer? |
| topic | Biomedical and clinical sciences Neurosciences Gut-microbiome-brain axis Autism spectrum disorders Gastrointestinal issues Drosophila |