Precision biomarker discovery in hypertension through explainable AI and proteomics
<p dir="ltr">Hypertension is a major global health burden and a leading driver of cardiovascular disease, yet reliable blood-based biomarkers for early disease are still limited. We combined plasma proteomics with explainable machine learning to identify circulating proteins associat...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2026
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513537073741824 |
|---|---|
| author | Karthik Sekaran (16845959) |
| author2 | Hatem Zayed (835448) |
| author2_role | author |
| author_facet | Karthik Sekaran (16845959) Hatem Zayed (835448) |
| author_role | author |
| dc.creator.none.fl_str_mv | Karthik Sekaran (16845959) Hatem Zayed (835448) |
| dc.date.none.fl_str_mv | 2026-04-22T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41371-026-01134-9 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Precision_biomarker_discovery_in_hypertension_through_explainable_AI_and_proteomics/32122279 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Information and computing sciences Machine learning Hypertension Cardiovascular disease Plasma proteomics Biomarkers Qatar Biobank Machine learning |
| dc.title.none.fl_str_mv | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Hypertension is a major global health burden and a leading driver of cardiovascular disease, yet reliable blood-based biomarkers for early disease are still limited. We combined plasma proteomics with explainable machine learning to identify circulating proteins associated with stage 1 hypertension in the Qatar Biobank. Proteomic profiles from 778 participants (554 controls and 224 stage 1 hypertension cases) were analyzed; 1305 proteins were tested for differential expression with adjustment for age and sex, and top features were prioritized before training predictive models. Among the evaluated classifiers, CatBoost performed best (AUROC = 0.7985), and SHapley Additive exPlanations were used to interpret the model. We identified 36 proteins significantly associated with hypertension and observed a characteristic pattern featuring lower Renin, sRAGE, ghrelin, and IL-1RAcP, and higher TFPI, QORL1, HSP70, and C5a in hypertensive individuals. Pathway and network analyses implicated processes related to oxidative stress and vascular function. Together, these results demonstrate Renin, TFPI, sRAGE, QORL1, ghrelin, HSP70, IL-1RAcP, and C5a as candidate circulating biomarkers for hypertension and illustrate the value of explainable AI for translating proteomic signals into potentially clinically interpretable candidates, pending validation in independent and diverse cohorts.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of Human Hypertension<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41371-026-01134-9" target="_blank">https://dx.doi.org/10.1038/s41371-026-01134-9</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_95154f1a2f557e3acd4482e0c7780cce |
| identifier_str_mv | 10.1038/s41371-026-01134-9 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/32122279 |
| publishDate | 2026 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Precision biomarker discovery in hypertension through explainable AI and proteomicsKarthik Sekaran (16845959)Hatem Zayed (835448)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesInformation and computing sciencesMachine learningHypertensionCardiovascular diseasePlasma proteomicsBiomarkersQatar BiobankMachine learning<p dir="ltr">Hypertension is a major global health burden and a leading driver of cardiovascular disease, yet reliable blood-based biomarkers for early disease are still limited. We combined plasma proteomics with explainable machine learning to identify circulating proteins associated with stage 1 hypertension in the Qatar Biobank. Proteomic profiles from 778 participants (554 controls and 224 stage 1 hypertension cases) were analyzed; 1305 proteins were tested for differential expression with adjustment for age and sex, and top features were prioritized before training predictive models. Among the evaluated classifiers, CatBoost performed best (AUROC = 0.7985), and SHapley Additive exPlanations were used to interpret the model. We identified 36 proteins significantly associated with hypertension and observed a characteristic pattern featuring lower Renin, sRAGE, ghrelin, and IL-1RAcP, and higher TFPI, QORL1, HSP70, and C5a in hypertensive individuals. Pathway and network analyses implicated processes related to oxidative stress and vascular function. Together, these results demonstrate Renin, TFPI, sRAGE, QORL1, ghrelin, HSP70, IL-1RAcP, and C5a as candidate circulating biomarkers for hypertension and illustrate the value of explainable AI for translating proteomic signals into potentially clinically interpretable candidates, pending validation in independent and diverse cohorts.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of Human Hypertension<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41371-026-01134-9" target="_blank">https://dx.doi.org/10.1038/s41371-026-01134-9</a></p>2026-04-22T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41371-026-01134-9https://figshare.com/articles/journal_contribution/Precision_biomarker_discovery_in_hypertension_through_explainable_AI_and_proteomics/32122279CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/321222792026-04-22T09:00:00Z |
| spellingShingle | Precision biomarker discovery in hypertension through explainable AI and proteomics Karthik Sekaran (16845959) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Information and computing sciences Machine learning Hypertension Cardiovascular disease Plasma proteomics Biomarkers Qatar Biobank Machine learning |
| status_str | publishedVersion |
| title | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| title_full | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| title_fullStr | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| title_full_unstemmed | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| title_short | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| title_sort | Precision biomarker discovery in hypertension through explainable AI and proteomics |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Information and computing sciences Machine learning Hypertension Cardiovascular disease Plasma proteomics Biomarkers Qatar Biobank Machine learning |