System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases
<div><p>Renal cell carcinoma (RCC) is a type of cancer that develops in the renal epithelium of the kidney. It is responsible for approximately 3% of adult malignancies, and 90–95% of neoplasms originate from the kidney. Advances in tumor diagnosis, innovative immune therapeutics, and ch...
محفوظ في:
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513519762800640 |
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| author | Md. Saddam Hossen (18278698) |
| author2 | Abdus Samad (4388131) Foysal Ahammad (9286524) Gabriel B.K. Sasa (18278701) Zhenggang Jiang (801908) Xianfeng Ding (535904) |
| author2_role | author author author author author |
| author_facet | Md. Saddam Hossen (18278698) Abdus Samad (4388131) Foysal Ahammad (9286524) Gabriel B.K. Sasa (18278701) Zhenggang Jiang (801908) Xianfeng Ding (535904) |
| author_role | author |
| dc.creator.none.fl_str_mv | Md. Saddam Hossen (18278698) Abdus Samad (4388131) Foysal Ahammad (9286524) Gabriel B.K. Sasa (18278701) Zhenggang Jiang (801908) Xianfeng Ding (535904) |
| dc.date.none.fl_str_mv | 2022-11-21T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1042/bsr20221108 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/System_biology_approaches_identified_novel_biomarkers_and_their_signaling_pathways_involved_in_renal_cell_carcinoma_with_different_human_diseases/25513879 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Functional enrichment PPI and Regulatory biomolecules Renal cell carcinoma Survival analysis System biology Transcriptional profile and Comorbidity |
| dc.title.none.fl_str_mv | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Renal cell carcinoma (RCC) is a type of cancer that develops in the renal epithelium of the kidney. It is responsible for approximately 3% of adult malignancies, and 90–95% of neoplasms originate from the kidney. Advances in tumor diagnosis, innovative immune therapeutics, and checkpoint inhibitors-based treatment options improved the survival rate of patients with RCC accompanied by different risk factors. RCC patients with diabetes, hepatitis C virus (HCV), or obesity (OB) may have a comorbidity, and finding the risk factor for better clinical treatment is an urgent issue. Therefore, the study focused on network-based gene expression analysis approaches to learning the impact of RCC on other comorbidities associated with the disease. The study found critical genetic factors and signal transduction pathways that share pathophysiology and commonly use dysregulated genes of the illness. Initially, the study identified 385 up-regulated genes and 338 down-regulated genes involved with RCC. OB, chronic kidney disease (CKD), type 2 diabetes (T2D), and HCV significantly shared 28, 14, 5, and 3 genes, respectively. RCC shared one down-regulated gene versican (VCAN) with OB and HCV and one down-regulated gene oxidase homolog 2 (LOXL2) with OB and CKD. Interestingly, most of the shared pathways were linked with metabolism. The study also identified six prospective biomarkers, signaling pathways, and numerous critical regulatory and associated drug candidates for the disease. We believe that the discovery will help explain these diseases’ complicated interplay and aid in developing novel therapeutic targets and drug candidates.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Bioscience Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1042/bsr20221108" target="_blank">https://dx.doi.org/10.1042/bsr20221108</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_95a4db4f76ec4095260f325df5a80bed |
| identifier_str_mv | 10.1042/bsr20221108 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25513879 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseasesMd. Saddam Hossen (18278698)Abdus Samad (4388131)Foysal Ahammad (9286524)Gabriel B.K. Sasa (18278701)Zhenggang Jiang (801908)Xianfeng Ding (535904)Biological sciencesBiochemistry and cell biologyFunctional enrichmentPPI and Regulatory biomoleculesRenal cell carcinomaSurvival analysisSystem biologyTranscriptional profile and Comorbidity<div><p>Renal cell carcinoma (RCC) is a type of cancer that develops in the renal epithelium of the kidney. It is responsible for approximately 3% of adult malignancies, and 90–95% of neoplasms originate from the kidney. Advances in tumor diagnosis, innovative immune therapeutics, and checkpoint inhibitors-based treatment options improved the survival rate of patients with RCC accompanied by different risk factors. RCC patients with diabetes, hepatitis C virus (HCV), or obesity (OB) may have a comorbidity, and finding the risk factor for better clinical treatment is an urgent issue. Therefore, the study focused on network-based gene expression analysis approaches to learning the impact of RCC on other comorbidities associated with the disease. The study found critical genetic factors and signal transduction pathways that share pathophysiology and commonly use dysregulated genes of the illness. Initially, the study identified 385 up-regulated genes and 338 down-regulated genes involved with RCC. OB, chronic kidney disease (CKD), type 2 diabetes (T2D), and HCV significantly shared 28, 14, 5, and 3 genes, respectively. RCC shared one down-regulated gene versican (VCAN) with OB and HCV and one down-regulated gene oxidase homolog 2 (LOXL2) with OB and CKD. Interestingly, most of the shared pathways were linked with metabolism. The study also identified six prospective biomarkers, signaling pathways, and numerous critical regulatory and associated drug candidates for the disease. We believe that the discovery will help explain these diseases’ complicated interplay and aid in developing novel therapeutic targets and drug candidates.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Bioscience Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1042/bsr20221108" target="_blank">https://dx.doi.org/10.1042/bsr20221108</a></p>2022-11-21T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1042/bsr20221108https://figshare.com/articles/journal_contribution/System_biology_approaches_identified_novel_biomarkers_and_their_signaling_pathways_involved_in_renal_cell_carcinoma_with_different_human_diseases/25513879CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/255138792022-11-21T03:00:00Z |
| spellingShingle | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases Md. Saddam Hossen (18278698) Biological sciences Biochemistry and cell biology Functional enrichment PPI and Regulatory biomolecules Renal cell carcinoma Survival analysis System biology Transcriptional profile and Comorbidity |
| status_str | publishedVersion |
| title | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| title_full | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| title_fullStr | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| title_full_unstemmed | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| title_short | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| title_sort | System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases |
| topic | Biological sciences Biochemistry and cell biology Functional enrichment PPI and Regulatory biomolecules Renal cell carcinoma Survival analysis System biology Transcriptional profile and Comorbidity |