Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

<p>One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common...

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Main Author: Fatma Ben Abid (14150799) (author)
Other Authors: Clement K. M. Tsui (8732583) (author), Yohei Doi (188766) (author), Anand Deshmukh (703820) (author), Christi L. McElheny (14150802) (author), William C. Bachman (14150805) (author), Erin L. Fowler (14150808) (author), Ahmed Albishawi (14150811) (author), Kamran Mushtaq (14150814) (author), Emad B. Ibrahim (9291062) (author), Sanjay H. Doiphode (14150817) (author), Manal M. Hamed (14150820) (author), Muna A. Almaslmani (14150823) (author), Abdullatif Alkhal (9538626) (author), Adeel A. Butt (3697705) (author), Ali S. Omrani (9590116) (author)
Published: 2022
Subjects:
Clinical sciences
Medical microbiology
Infectious Diseases
Microbiology (medical)
General Medicine
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Summary:<p>One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).</p><h2>Other Information</h2> <p> Published in: European Journal of Clinical Microbiology & Infectious Diseases<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s10096-021-04185-7" target="_blank">http://dx.doi.org/10.1007/s10096-021-04185-7</a></p>

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