Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
<p dir="ltr">Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical li...
محفوظ في:
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| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513515337809920 |
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| author | Rozaimi Mohamad Razali (18589444) |
| author2 | Juan Rodriguez-Flores (3497981) Mohammadmersad Ghorbani (12375321) Haroon Naeem (209167) Waleed Aamer (14056969) Elbay Aliyev (14056972) Ali Jubran (18589447) Said I. Ismail (11721428) Wadha Al-Muftah (14152551) Radja Badji (14152548) Hamdi Mbarek (134997) Dima Darwish (14152545) Tasnim Fadl (14152533) Heba Yasin (14152542) Maryem Ennaifar (14778556) Rania Abdellatif (18589450) Fatima Alkuwari (14778562) Muhammad Alvi (4831311) Yasser Al-Sarraj (11721425) Chadi Saad (5369351) Asmaa Althani (499903) Eleni Fethnou (14778568) Fatima Qafoud (14778571) Eiman Alkhayat (14778574) Nahla Afifi (193245) Sara Tomei (3441323) Wei Liu (20030) Stephan Lorenz (466378) Najeeb Syed (12561967) Hakeem Almabrazi (6561371) Fazulur Rehaman Vempalli (14778577) Ramzi Temanni (671528) Tariq Abu Saqri (14778580) Mohammedhusen Khatib (14778583) Mehshad Hamza (14778586) Tariq Abu Zaid (14778589) Ahmed El Khouly (14778592) Tushar Pathare (14778595) Shafeeq Poolat (14778598) Rashid Al-Ali (846229) Omar Albagha (8977856) Souhaila Al-Khodor (247417) Mashael Alshafai (14778607) Ramin Badii (491543) Lotfi Chouchane (61840) Xavier Estivill (23803) Khalid A. Fakhro (3158862) Younes Mokrab (6367) Jithesh V. Puthen (14778610) Karsten Suhre (67967) Zohreh Tatari (14778613) Andrew G. Clark (8569380) Qatar Genome Program Research Consortium (14780431) Qatar Genome Project Management (14778619) Biobank and Sample Preparation (14778622) Sequencing and Genotyping group (14778625) Applied Bioinformatics Core (14778628) Data Management and Computing Infrastructure group (14778631) Consortium Lead Principal Investigators (in alphabetical order) (18589453) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Rozaimi Mohamad Razali (18589444) Juan Rodriguez-Flores (3497981) Mohammadmersad Ghorbani (12375321) Haroon Naeem (209167) Waleed Aamer (14056969) Elbay Aliyev (14056972) Ali Jubran (18589447) Said I. Ismail (11721428) Wadha Al-Muftah (14152551) Radja Badji (14152548) Hamdi Mbarek (134997) Dima Darwish (14152545) Tasnim Fadl (14152533) Heba Yasin (14152542) Maryem Ennaifar (14778556) Rania Abdellatif (18589450) Fatima Alkuwari (14778562) Muhammad Alvi (4831311) Yasser Al-Sarraj (11721425) Chadi Saad (5369351) Asmaa Althani (499903) Eleni Fethnou (14778568) Fatima Qafoud (14778571) Eiman Alkhayat (14778574) Nahla Afifi (193245) Sara Tomei (3441323) Wei Liu (20030) Stephan Lorenz (466378) Najeeb Syed (12561967) Hakeem Almabrazi (6561371) Fazulur Rehaman Vempalli (14778577) Ramzi Temanni (671528) Tariq Abu Saqri (14778580) Mohammedhusen Khatib (14778583) Mehshad Hamza (14778586) Tariq Abu Zaid (14778589) Ahmed El Khouly (14778592) Tushar Pathare (14778595) Shafeeq Poolat (14778598) Rashid Al-Ali (846229) Omar Albagha (8977856) Souhaila Al-Khodor (247417) Mashael Alshafai (14778607) Ramin Badii (491543) Lotfi Chouchane (61840) Xavier Estivill (23803) Khalid A. Fakhro (3158862) Younes Mokrab (6367) Jithesh V. Puthen (14778610) Karsten Suhre (67967) Zohreh Tatari (14778613) Andrew G. Clark (8569380) Qatar Genome Program Research Consortium (14780431) Qatar Genome Project Management (14778619) Biobank and Sample Preparation (14778622) Sequencing and Genotyping group (14778625) Applied Bioinformatics Core (14778628) Data Management and Computing Infrastructure group (14778631) Consortium Lead Principal Investigators (in alphabetical order) (18589453) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rozaimi Mohamad Razali (18589444) Juan Rodriguez-Flores (3497981) Mohammadmersad Ghorbani (12375321) Haroon Naeem (209167) Waleed Aamer (14056969) Elbay Aliyev (14056972) Ali Jubran (18589447) Said I. Ismail (11721428) Wadha Al-Muftah (14152551) Radja Badji (14152548) Hamdi Mbarek (134997) Dima Darwish (14152545) Tasnim Fadl (14152533) Heba Yasin (14152542) Maryem Ennaifar (14778556) Rania Abdellatif (18589450) Fatima Alkuwari (14778562) Muhammad Alvi (4831311) Yasser Al-Sarraj (11721425) Chadi Saad (5369351) Asmaa Althani (499903) Eleni Fethnou (14778568) Fatima Qafoud (14778571) Eiman Alkhayat (14778574) Nahla Afifi (193245) Sara Tomei (3441323) Wei Liu (20030) Stephan Lorenz (466378) Najeeb Syed (12561967) Hakeem Almabrazi (6561371) Fazulur Rehaman Vempalli (14778577) Ramzi Temanni (671528) Tariq Abu Saqri (14778580) Mohammedhusen Khatib (14778583) Mehshad Hamza (14778586) Tariq Abu Zaid (14778589) Ahmed El Khouly (14778592) Tushar Pathare (14778595) Shafeeq Poolat (14778598) Rashid Al-Ali (846229) Omar Albagha (8977856) Souhaila Al-Khodor (247417) Mashael Alshafai (14778607) Ramin Badii (491543) Lotfi Chouchane (61840) Xavier Estivill (23803) Khalid A. Fakhro (3158862) Younes Mokrab (6367) Jithesh V. Puthen (14778610) Karsten Suhre (67967) Zohreh Tatari (14778613) Andrew G. Clark (8569380) Qatar Genome Program Research Consortium (14780431) Qatar Genome Project Management (14778619) Biobank and Sample Preparation (14778622) Sequencing and Genotyping group (14778625) Applied Bioinformatics Core (14778628) Data Management and Computing Infrastructure group (14778631) Consortium Lead Principal Investigators (in alphabetical order) (18589453) |
| dc.date.none.fl_str_mv | 2021-10-12T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41467-021-25287-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Thousands_of_Qatari_genomes_inform_human_migration_history_and_improve_imputation_of_Arab_haplotypes/25867687 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Arab populations Genetic structure Genetic history Whole genomes Qatar Genetic diversity Ancestries |
| dc.title.none.fl_str_mv | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical lineages of Qahtanite (Peninsular Arabs) and Adnanite (General Arabs and West Eurasian Arabs). We find that Peninsular Arabs are the closest relatives of ancient hunter-gatherers and Neolithic farmers from the Levant, and that founder Arab populations experienced multiple splitting events 12–20 kya, consistent with the aridification of Arabia and farming in the Levant, giving rise to settler and nomadic communities. In terms of recent genetic flow, we show that these ancestries contributed significantly to European, South Asian as well as South American populations, likely as a result of Islamic expansion over the past 1400 years. Notably, we characterize a large cohort of men with the ChrY J1a2b haplogroup (n = 1,491), identifying 29 unique sub-haplogroups. Finally, we leverage genotype novelty to build a reference panel of 12,432 haplotypes, demonstrating improved genotype imputation for both rare and common alleles in Arabs and the wider Middle East.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-021-25287-y" target="_blank">https://dx.doi.org/10.1038/s41467-021-25287-y</a></p><p dir="ltr">Additional institutions affiliated with: Qatar University Health - QU</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_96e68018f2da3eff2c71cfca5604e273 |
| identifier_str_mv | 10.1038/s41467-021-25287-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25867687 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypesRozaimi Mohamad Razali (18589444)Juan Rodriguez-Flores (3497981)Mohammadmersad Ghorbani (12375321)Haroon Naeem (209167)Waleed Aamer (14056969)Elbay Aliyev (14056972)Ali Jubran (18589447)Said I. Ismail (11721428)Wadha Al-Muftah (14152551)Radja Badji (14152548)Hamdi Mbarek (134997)Dima Darwish (14152545)Tasnim Fadl (14152533)Heba Yasin (14152542)Maryem Ennaifar (14778556)Rania Abdellatif (18589450)Fatima Alkuwari (14778562)Muhammad Alvi (4831311)Yasser Al-Sarraj (11721425)Chadi Saad (5369351)Asmaa Althani (499903)Eleni Fethnou (14778568)Fatima Qafoud (14778571)Eiman Alkhayat (14778574)Nahla Afifi (193245)Sara Tomei (3441323)Wei Liu (20030)Stephan Lorenz (466378)Najeeb Syed (12561967)Hakeem Almabrazi (6561371)Fazulur Rehaman Vempalli (14778577)Ramzi Temanni (671528)Tariq Abu Saqri (14778580)Mohammedhusen Khatib (14778583)Mehshad Hamza (14778586)Tariq Abu Zaid (14778589)Ahmed El Khouly (14778592)Tushar Pathare (14778595)Shafeeq Poolat (14778598)Rashid Al-Ali (846229)Omar Albagha (8977856)Souhaila Al-Khodor (247417)Mashael Alshafai (14778607)Ramin Badii (491543)Lotfi Chouchane (61840)Xavier Estivill (23803)Khalid A. Fakhro (3158862)Younes Mokrab (6367)Jithesh V. Puthen (14778610)Karsten Suhre (67967)Zohreh Tatari (14778613)Andrew G. Clark (8569380)Qatar Genome Program Research Consortium (14780431)Qatar Genome Project Management (14778619)Biobank and Sample Preparation (14778622)Sequencing and Genotyping group (14778625)Applied Bioinformatics Core (14778628)Data Management and Computing Infrastructure group (14778631)Consortium Lead Principal Investigators (in alphabetical order) (18589453)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesArab populationsGenetic structureGenetic historyWhole genomesQatarGenetic diversityAncestries<p dir="ltr">Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical lineages of Qahtanite (Peninsular Arabs) and Adnanite (General Arabs and West Eurasian Arabs). We find that Peninsular Arabs are the closest relatives of ancient hunter-gatherers and Neolithic farmers from the Levant, and that founder Arab populations experienced multiple splitting events 12–20 kya, consistent with the aridification of Arabia and farming in the Levant, giving rise to settler and nomadic communities. In terms of recent genetic flow, we show that these ancestries contributed significantly to European, South Asian as well as South American populations, likely as a result of Islamic expansion over the past 1400 years. Notably, we characterize a large cohort of men with the ChrY J1a2b haplogroup (n = 1,491), identifying 29 unique sub-haplogroups. Finally, we leverage genotype novelty to build a reference panel of 12,432 haplotypes, demonstrating improved genotype imputation for both rare and common alleles in Arabs and the wider Middle East.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-021-25287-y" target="_blank">https://dx.doi.org/10.1038/s41467-021-25287-y</a></p><p dir="ltr">Additional institutions affiliated with: Qatar University Health - QU</p>2021-10-12T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41467-021-25287-yhttps://figshare.com/articles/journal_contribution/Thousands_of_Qatari_genomes_inform_human_migration_history_and_improve_imputation_of_Arab_haplotypes/25867687CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258676872021-10-12T03:00:00Z |
| spellingShingle | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes Rozaimi Mohamad Razali (18589444) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Arab populations Genetic structure Genetic history Whole genomes Qatar Genetic diversity Ancestries |
| status_str | publishedVersion |
| title | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| title_full | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| title_fullStr | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| title_full_unstemmed | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| title_short | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| title_sort | Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Arab populations Genetic structure Genetic history Whole genomes Qatar Genetic diversity Ancestries |