Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer
<p dir="ltr">Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addit...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2020
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513511427670016 |
|---|---|
| author | Mariam Abotaleb (18808261) |
| author2 | Alena Liskova (11008851) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| author2_role | author author author |
| author_facet | Mariam Abotaleb (18808261) Alena Liskova (11008851) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mariam Abotaleb (18808261) Alena Liskova (11008851) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| dc.date.none.fl_str_mv | 2020-02-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/biom10020221 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Therapeutic_Potential_of_Plant_Phenolic_Acids_in_the_Treatment_of_Cancer/26019448 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences phenolics cancer proliferation apoptosis metastasis benzoic acids cinnamic acids |
| dc.title.none.fl_str_mv | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomolecules<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/biom10020221" target="_blank">https://dx.doi.org/10.3390/biom10020221</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_982d66efbf6748273889f979f67db3fd |
| identifier_str_mv | 10.3390/biom10020221 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26019448 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Therapeutic Potential of Plant Phenolic Acids in the Treatment of CancerMariam Abotaleb (18808261)Alena Liskova (11008851)Peter Kubatka (11008854)Dietrich Büsselberg (11008857)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesphenolicscancerproliferationapoptosismetastasisbenzoic acidscinnamic acids<p dir="ltr">Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomolecules<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/biom10020221" target="_blank">https://dx.doi.org/10.3390/biom10020221</a></p>2020-02-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/biom10020221https://figshare.com/articles/journal_contribution/Therapeutic_Potential_of_Plant_Phenolic_Acids_in_the_Treatment_of_Cancer/26019448CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260194482020-02-03T03:00:00Z |
| spellingShingle | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer Mariam Abotaleb (18808261) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences phenolics cancer proliferation apoptosis metastasis benzoic acids cinnamic acids |
| status_str | publishedVersion |
| title | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| title_full | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| title_fullStr | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| title_full_unstemmed | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| title_short | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| title_sort | Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences phenolics cancer proliferation apoptosis metastasis benzoic acids cinnamic acids |