Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration

Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration

<h3>Background</h3><p dir="ltr"><u>TRPM4</u> is a broadly expressed, calcium-activated, <u>monovalent</u> cation channel that regulates <u>immune cell</u> function in mice and cell lines. Clinically, however, partial loss- or gain-of-fu...

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Main Author: Fang Yu (156838) (author)
Other Authors: Satanay Hubrack (194364) (author), Christophe M. Raynaud (102751) (author), Asha Elmi (9592371) (author), Rafah Mackeh (14151225) (author), Nourhen Agrebi (14151222) (author), Gaurav Thareja (459188) (author), Abdelaziz Belkadi (21842165) (author), Hesham Al Saloos (21842168) (author), Ayeda Abdulsalam Ahmed (10327970) (author), Saleema C. Purayil (21459884) (author), Yasmin A. Mohamoud (10671696) (author), Karsten Suhre (67967) (author), Charbel Abi Khalil (781797) (author), Frank Schmidt (207186) (author), Bernice Lo (3441317) (author), Amel Hassan (14151231) (author), Khaled Machaca (194372) (author)
Published: 2024
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Immunology
TRPM4
immune dysregulation
monocyte
migration
loss of function
infections
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