When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus
<p dir="ltr">The coexistence of systemic lupus erythematosus (SLE) and Wilson's disease (WD) is exceedingly rare, posing significant diagnostic challenges due to overlapping clinical presentations. Neurological and psychiatric manifestations commonly associated with WD can obscu...
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2025
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| _version_ | 1864513538095054848 |
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| author | Suresh Bhagoowani (22330471) |
| author2 | Uooja Devi (22330474) Aqsa Munir (9073801) Ummulkiram Hasnain (22330477) Saad Khan (296295) Javed Iqbal (2121922) Tehseen Akhtar (22330480) |
| author2_role | author author author author author author |
| author_facet | Suresh Bhagoowani (22330471) Uooja Devi (22330474) Aqsa Munir (9073801) Ummulkiram Hasnain (22330477) Saad Khan (296295) Javed Iqbal (2121922) Tehseen Akhtar (22330480) |
| author_role | author |
| dc.creator.none.fl_str_mv | Suresh Bhagoowani (22330471) Uooja Devi (22330474) Aqsa Munir (9073801) Ummulkiram Hasnain (22330477) Saad Khan (296295) Javed Iqbal (2121922) Tehseen Akhtar (22330480) |
| dc.date.none.fl_str_mv | 2025-02-19T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/ccr3.70159 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/When_Copper_Meets_Autoimmunity_A_Rare_Coexistence_of_Wilson_s_Disease_and_Systemic_Lupus_Erythematosus/30233977 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Neurosciences autoimmune disorders diagnosis systemic lupus erythematosus treatment Wilson's disease |
| dc.title.none.fl_str_mv | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The coexistence of systemic lupus erythematosus (SLE) and Wilson's disease (WD) is exceedingly rare, posing significant diagnostic challenges due to overlapping clinical presentations. Neurological and psychiatric manifestations commonly associated with WD can obscure or mimic symptoms of other systemic diseases, complicating accurate diagnosis and management. We report the case of a 17‐year‐old female diagnosed with WD and concurrent SLE, treated at Civil Hospital, Karachi, Pakistan. The patient initially presented with neuropsychiatric symptoms typical of WD, confirmed by diagnostic findings indicative of hepatic copper accumulation. She later developed significant proteinuria, hematuria, fever, and positive autoimmune serologies, raising suspicion of concurrent SLE. Despite therapeutic interventions, including methylprednisolone (1 mg), the patient's condition deteriorated, and she unfortunately succumbed to complications from a blood transfusion reaction. This case underscores the importance of heightened clinical vigilance when managing overlapping presentations of WD and systemic autoimmune disorders like SLE. Early recognition of WD‐specific neurological and psychiatric symptoms is critical for timely diagnosis and intervention, potentially mitigating the risk of severe complications and poor outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70159" target="_blank">https://dx.doi.org/10.1002/ccr3.70159</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9a0e01e976ae85dada93ad5de4fe4d8a |
| identifier_str_mv | 10.1002/ccr3.70159 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30233977 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus ErythematosusSuresh Bhagoowani (22330471)Uooja Devi (22330474)Aqsa Munir (9073801)Ummulkiram Hasnain (22330477)Saad Khan (296295)Javed Iqbal (2121922)Tehseen Akhtar (22330480)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsNeurosciencesautoimmune disordersdiagnosissystemic lupus erythematosustreatmentWilson's disease<p dir="ltr">The coexistence of systemic lupus erythematosus (SLE) and Wilson's disease (WD) is exceedingly rare, posing significant diagnostic challenges due to overlapping clinical presentations. Neurological and psychiatric manifestations commonly associated with WD can obscure or mimic symptoms of other systemic diseases, complicating accurate diagnosis and management. We report the case of a 17‐year‐old female diagnosed with WD and concurrent SLE, treated at Civil Hospital, Karachi, Pakistan. The patient initially presented with neuropsychiatric symptoms typical of WD, confirmed by diagnostic findings indicative of hepatic copper accumulation. She later developed significant proteinuria, hematuria, fever, and positive autoimmune serologies, raising suspicion of concurrent SLE. Despite therapeutic interventions, including methylprednisolone (1 mg), the patient's condition deteriorated, and she unfortunately succumbed to complications from a blood transfusion reaction. This case underscores the importance of heightened clinical vigilance when managing overlapping presentations of WD and systemic autoimmune disorders like SLE. Early recognition of WD‐specific neurological and psychiatric symptoms is critical for timely diagnosis and intervention, potentially mitigating the risk of severe complications and poor outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70159" target="_blank">https://dx.doi.org/10.1002/ccr3.70159</a></p>2025-02-19T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/ccr3.70159https://figshare.com/articles/journal_contribution/When_Copper_Meets_Autoimmunity_A_Rare_Coexistence_of_Wilson_s_Disease_and_Systemic_Lupus_Erythematosus/30233977CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302339772025-02-19T09:00:00Z |
| spellingShingle | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus Suresh Bhagoowani (22330471) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Neurosciences autoimmune disorders diagnosis systemic lupus erythematosus treatment Wilson's disease |
| status_str | publishedVersion |
| title | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| title_full | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| title_fullStr | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| title_full_unstemmed | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| title_short | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| title_sort | When Copper Meets Autoimmunity: A Rare Coexistence of Wilson's Disease and Systemic Lupus Erythematosus |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Neurosciences autoimmune disorders diagnosis systemic lupus erythematosus treatment Wilson's disease |