Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients
<h3>Background</h3><p dir="ltr">The management of chronic kidney disease (CKD) and its complications places a significant burden on patients, resulting in impairment of their health-related quality of life (HR-QOL). Little is known about treatment-related burden in pre-di...
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2021
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| author | Asmaa Al-mansouri (16931739) |
| author2 | Fadwa Saqr Al-Ali (16931742) Abdullah Ibrahim Hamad (11172677) Mohamed Izham Mohamed Ibrahim (14158896) Nadir Kheir (47876) Rania Abdelaziz Ibrahim (16931745) Muna AlBakri (16931748) Ahmed Awaisu (5121473) |
| author2_role | author author author author author author author |
| author_facet | Asmaa Al-mansouri (16931739) Fadwa Saqr Al-Ali (16931742) Abdullah Ibrahim Hamad (11172677) Mohamed Izham Mohamed Ibrahim (14158896) Nadir Kheir (47876) Rania Abdelaziz Ibrahim (16931745) Muna AlBakri (16931748) Ahmed Awaisu (5121473) |
| author_role | author |
| dc.creator.none.fl_str_mv | Asmaa Al-mansouri (16931739) Fadwa Saqr Al-Ali (16931742) Abdullah Ibrahim Hamad (11172677) Mohamed Izham Mohamed Ibrahim (14158896) Nadir Kheir (47876) Rania Abdelaziz Ibrahim (16931745) Muna AlBakri (16931748) Ahmed Awaisu (5121473) |
| dc.date.none.fl_str_mv | 2021-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.sapharm.2021.02.010 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Assessment_of_treatment_burden_and_its_impact_on_quality_of_life_in_dialysis-dependent_and_pre-dialysis_chronic_kidney_disease_patients/24083151 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Chronic kidney disease Dialysis Quality of life Treatment burden Medication burden Patient-reported outcome |
| dc.title.none.fl_str_mv | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">The management of chronic kidney disease (CKD) and its complications places a significant burden on patients, resulting in impairment of their health-related quality of life (HR-QOL). Little is known about treatment-related burden in pre-dialysis and hemodialysis (HD) CKD patients.ObjectiveThis study aimed to investigate the magnitude of treatment-related burden and its impact on HR-QOL among patients with CKD.</p><h3>Methods</h3><p dir="ltr">This was a prospective, cross-sectional study to assess treatment-related burden and HR-QOL among patients with CKD in Qatar. Treatment-related burden and HR-QOL were assessed quantitatively using the Treatment Burden Questionnaire (TBQ) and the Kidney Disease Quality of Life (KDQOL™) questionnaire, respectively. The total TBQ score ranges from 0 to 150, with a higher score indicating higher treatment burden, while the range of total possible scores for the KDQOL™ are from 0 to 3600 with higher transformed score indicating better QOL. Pre-dialysis and hemodialysis (HD) CKD patients who had regular follow-up appointments at Fahad Bin Jassim Kidney Center in Qatar were enrolled. Data were analyzed descriptively and inferentially using SPSS version-24.</p><h3>Results</h3><p dir="ltr">Two hundred-eighty CKD patients (HD = 223 and pre-dialysis = 57) were included in the analyses (response rate 60.9%). Approximately 35% of the participants reported moderate to high treatment-related burden (TBQ global score 51–150). HD patients experienced significantly higher treatment burden compared to pre-dialysis patients with a median (IQR) score of 45 (36) versus 25 (33), respectively (p < 0.001). Medication burden and lifestyle changes burden were the highest perceived treatment-related burden. Overall, the perceived median (IQR) HR-QOL measured using the KDQOL-36™ among the participants was 2280.6 (1096.2) compared to the maximum global score of 3600. Similarly, the HD patients demonstrated significantly lower HR-QOL compared to the pre-dialysis patients [median (IQR) score of 2140 (1100) vs. 2930 (995), respectively; p < 0.001). There was a strong negative correlation between TBQ score and KDQOL-36™ score [rs (251) = −0.616, p < 0.001], signifying that HR-QOL decreases as treatment burden increases.</p><h3>Conclusions</h3><p dir="ltr">This study suggests that a considerable proportion of CKD patients suffered from treatment-related burden and deterioration in HR-QOL at a varying degree of seriousness. HD patients experienced significantly higher burden of treatment and lower HR-QOL compared to pre-dialysis patients and that HR-QOL declines as treatment burden increases. Therefore, treatment-related burden should be considered in CKD management and factors that increase it should be considered when designing healthcare interventions directed to CKD patients.</p><h2>Other Information</h2><p dir="ltr">Published in: Research in Social and Administrative Pharmacy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.sapharm.2021.02.010" target="_blank">https://dx.doi.org/10.1016/j.sapharm.2021.02.010</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9acd5e8a8355ddab06f9b437a77bdb1e |
| identifier_str_mv | 10.1016/j.sapharm.2021.02.010 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24083151 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patientsAsmaa Al-mansouri (16931739)Fadwa Saqr Al-Ali (16931742)Abdullah Ibrahim Hamad (11172677)Mohamed Izham Mohamed Ibrahim (14158896)Nadir Kheir (47876)Rania Abdelaziz Ibrahim (16931745)Muna AlBakri (16931748)Ahmed Awaisu (5121473)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesChronic kidney diseaseDialysisQuality of lifeTreatment burdenMedication burdenPatient-reported outcome<h3>Background</h3><p dir="ltr">The management of chronic kidney disease (CKD) and its complications places a significant burden on patients, resulting in impairment of their health-related quality of life (HR-QOL). Little is known about treatment-related burden in pre-dialysis and hemodialysis (HD) CKD patients.ObjectiveThis study aimed to investigate the magnitude of treatment-related burden and its impact on HR-QOL among patients with CKD.</p><h3>Methods</h3><p dir="ltr">This was a prospective, cross-sectional study to assess treatment-related burden and HR-QOL among patients with CKD in Qatar. Treatment-related burden and HR-QOL were assessed quantitatively using the Treatment Burden Questionnaire (TBQ) and the Kidney Disease Quality of Life (KDQOL™) questionnaire, respectively. The total TBQ score ranges from 0 to 150, with a higher score indicating higher treatment burden, while the range of total possible scores for the KDQOL™ are from 0 to 3600 with higher transformed score indicating better QOL. Pre-dialysis and hemodialysis (HD) CKD patients who had regular follow-up appointments at Fahad Bin Jassim Kidney Center in Qatar were enrolled. Data were analyzed descriptively and inferentially using SPSS version-24.</p><h3>Results</h3><p dir="ltr">Two hundred-eighty CKD patients (HD = 223 and pre-dialysis = 57) were included in the analyses (response rate 60.9%). Approximately 35% of the participants reported moderate to high treatment-related burden (TBQ global score 51–150). HD patients experienced significantly higher treatment burden compared to pre-dialysis patients with a median (IQR) score of 45 (36) versus 25 (33), respectively (p < 0.001). Medication burden and lifestyle changes burden were the highest perceived treatment-related burden. Overall, the perceived median (IQR) HR-QOL measured using the KDQOL-36™ among the participants was 2280.6 (1096.2) compared to the maximum global score of 3600. Similarly, the HD patients demonstrated significantly lower HR-QOL compared to the pre-dialysis patients [median (IQR) score of 2140 (1100) vs. 2930 (995), respectively; p < 0.001). There was a strong negative correlation between TBQ score and KDQOL-36™ score [rs (251) = −0.616, p < 0.001], signifying that HR-QOL decreases as treatment burden increases.</p><h3>Conclusions</h3><p dir="ltr">This study suggests that a considerable proportion of CKD patients suffered from treatment-related burden and deterioration in HR-QOL at a varying degree of seriousness. HD patients experienced significantly higher burden of treatment and lower HR-QOL compared to pre-dialysis patients and that HR-QOL declines as treatment burden increases. Therefore, treatment-related burden should be considered in CKD management and factors that increase it should be considered when designing healthcare interventions directed to CKD patients.</p><h2>Other Information</h2><p dir="ltr">Published in: Research in Social and Administrative Pharmacy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.sapharm.2021.02.010" target="_blank">https://dx.doi.org/10.1016/j.sapharm.2021.02.010</a></p>2021-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.sapharm.2021.02.010https://figshare.com/articles/journal_contribution/Assessment_of_treatment_burden_and_its_impact_on_quality_of_life_in_dialysis-dependent_and_pre-dialysis_chronic_kidney_disease_patients/24083151CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/240831512021-11-01T00:00:00Z |
| spellingShingle | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients Asmaa Al-mansouri (16931739) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Chronic kidney disease Dialysis Quality of life Treatment burden Medication burden Patient-reported outcome |
| status_str | publishedVersion |
| title | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| title_full | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| title_fullStr | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| title_full_unstemmed | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| title_short | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| title_sort | Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Chronic kidney disease Dialysis Quality of life Treatment burden Medication burden Patient-reported outcome |