Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study
<h3>Objectives</h3><p dir="ltr">We assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection.</p><h3>Methods</h3><p dir="ltr">A national, matched, retrospective cohort study was conducted in Qa...
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2023
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| _version_ | 1864513507072933888 |
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| author | Hiam Chemaitelly (439114) |
| author2 | Jeremy Samuel Faust (19483087) Harlan M. Krumholz (9228267) Houssein H. Ayoub (9262512) Patrick Tang (239534) Peter Coyle (787159) Hadi M. Yassine (4675846) Asmaa A. Al Thani (10494576) Hebah A. Al-Khatib (6837266) Mohammad R. Hasan (13777597) Zaina Al-Kanaani (4557205) Einas Al-Kuwari (13777606) Andrew Jeremijenko (11506565) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hanan F. Abdul-Rahim (13777600) Gheyath K. Nasrallah (9200525) Mohamed Ghaith Al-Kuwari (4264192) Adeel A. Butt (3697705) Hamad Eid Al-Romaihi (6837251) Mohamed H. Al-Thani (11847049) Abdullatif Al-Khal (11721410) Roberto Bertollini (9538620) Laith J. Abu-Raddad (9262524) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Hiam Chemaitelly (439114) Jeremy Samuel Faust (19483087) Harlan M. Krumholz (9228267) Houssein H. Ayoub (9262512) Patrick Tang (239534) Peter Coyle (787159) Hadi M. Yassine (4675846) Asmaa A. Al Thani (10494576) Hebah A. Al-Khatib (6837266) Mohammad R. Hasan (13777597) Zaina Al-Kanaani (4557205) Einas Al-Kuwari (13777606) Andrew Jeremijenko (11506565) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hanan F. Abdul-Rahim (13777600) Gheyath K. Nasrallah (9200525) Mohamed Ghaith Al-Kuwari (4264192) Adeel A. Butt (3697705) Hamad Eid Al-Romaihi (6837251) Mohamed H. Al-Thani (11847049) Abdullatif Al-Khal (11721410) Roberto Bertollini (9538620) Laith J. Abu-Raddad (9262524) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hiam Chemaitelly (439114) Jeremy Samuel Faust (19483087) Harlan M. Krumholz (9228267) Houssein H. Ayoub (9262512) Patrick Tang (239534) Peter Coyle (787159) Hadi M. Yassine (4675846) Asmaa A. Al Thani (10494576) Hebah A. Al-Khatib (6837266) Mohammad R. Hasan (13777597) Zaina Al-Kanaani (4557205) Einas Al-Kuwari (13777606) Andrew Jeremijenko (11506565) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hanan F. Abdul-Rahim (13777600) Gheyath K. Nasrallah (9200525) Mohamed Ghaith Al-Kuwari (4264192) Adeel A. Butt (3697705) Hamad Eid Al-Romaihi (6837251) Mohamed H. Al-Thani (11847049) Abdullatif Al-Khal (11721410) Roberto Bertollini (9538620) Laith J. Abu-Raddad (9262524) |
| dc.date.none.fl_str_mv | 2023-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ijid.2023.09.005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Short-_and_longer-term_all-cause_mortality_among_SARS-CoV-2-_infected_individuals_and_the_pull-forward_phenomenon_in_Qatar_a_national_cohort_study/26830936 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Epidemiology Public health Acute infection Immunity Death Long COVID Cohort study Epidemiology |
| dc.title.none.fl_str_mv | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objectives</h3><p dir="ltr">We assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection.</p><h3>Methods</h3><p dir="ltr">A national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status.</p><h3>Results</h3><p dir="ltr">Among unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status.</p><h3>Conclusions</h3><p dir="ltr">COVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Infectious Diseases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ijid.2023.09.005" target="_blank">https://dx.doi.org/10.1016/j.ijid.2023.09.005</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9b1b03c7cd20b33211901c4ddae4cd12 |
| identifier_str_mv | 10.1016/j.ijid.2023.09.005 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26830936 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort studyHiam Chemaitelly (439114)Jeremy Samuel Faust (19483087)Harlan M. Krumholz (9228267)Houssein H. Ayoub (9262512)Patrick Tang (239534)Peter Coyle (787159)Hadi M. Yassine (4675846)Asmaa A. Al Thani (10494576)Hebah A. Al-Khatib (6837266)Mohammad R. Hasan (13777597)Zaina Al-Kanaani (4557205)Einas Al-Kuwari (13777606)Andrew Jeremijenko (11506565)Anvar Hassan Kaleeckal (11847034)Ali Nizar Latif (11570540)Riyazuddin Mohammad Shaik (11847037)Hanan F. Abdul-Rahim (13777600)Gheyath K. Nasrallah (9200525)Mohamed Ghaith Al-Kuwari (4264192)Adeel A. Butt (3697705)Hamad Eid Al-Romaihi (6837251)Mohamed H. Al-Thani (11847049)Abdullatif Al-Khal (11721410)Roberto Bertollini (9538620)Laith J. Abu-Raddad (9262524)Health sciencesEpidemiologyPublic healthAcute infectionImmunityDeathLong COVIDCohort studyEpidemiology<h3>Objectives</h3><p dir="ltr">We assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection.</p><h3>Methods</h3><p dir="ltr">A national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status.</p><h3>Results</h3><p dir="ltr">Among unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status.</p><h3>Conclusions</h3><p dir="ltr">COVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Infectious Diseases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ijid.2023.09.005" target="_blank">https://dx.doi.org/10.1016/j.ijid.2023.09.005</a></p>2023-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ijid.2023.09.005https://figshare.com/articles/journal_contribution/Short-_and_longer-term_all-cause_mortality_among_SARS-CoV-2-_infected_individuals_and_the_pull-forward_phenomenon_in_Qatar_a_national_cohort_study/26830936CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/268309362023-11-01T00:00:00Z |
| spellingShingle | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study Hiam Chemaitelly (439114) Health sciences Epidemiology Public health Acute infection Immunity Death Long COVID Cohort study Epidemiology |
| status_str | publishedVersion |
| title | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_full | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_fullStr | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_full_unstemmed | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_short | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_sort | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| topic | Health sciences Epidemiology Public health Acute infection Immunity Death Long COVID Cohort study Epidemiology |