Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus
<p dir="ltr">The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the...
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2022
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| _version_ | 1864513518726807552 |
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| author | Sima Tokajian (3559616) |
| author2 | Georgi Merhi (12877181) Charbel Al Khoury (13167975) Georges Nemer (295984) |
| author2_role | author author author |
| author_facet | Sima Tokajian (3559616) Georgi Merhi (12877181) Charbel Al Khoury (13167975) Georges Nemer (295984) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sima Tokajian (3559616) Georgi Merhi (12877181) Charbel Al Khoury (13167975) Georges Nemer (295984) |
| dc.date.none.fl_str_mv | 2022-01-13T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmicb.2021.788741 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Interleukin-37_A_Link_Between_COVID-19_Diabetes_and_the_Black_Fungus/25662633 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology COVID-19 T2D corticosteroids mucormycosis IL-37 |
| dc.title.none.fl_str_mv | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the maxillofacial region, namely mucormycosis, was linked to a deadly infection known as black fungus. Black fungus, diabetes, corticosteroids, and coronavirus disease 2019 (COVID-19) all have a dysregulated immune response in common, which partly could also be attributed to interleukin 37 (IL-37). IL-37, a new cytokine of the IL-1 family, known for broadly reducing innate inflammation as well as acquired immune responses. The use of corticosteroids in diabetic COVID-19 patients, crowded hospitals, and lack of medical oxygen should be carefully considered to reduce COVID-associated secondary infections.</p><p dir="ltr"><br></p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Microbiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmicb.2021.788741" target="_blank">https://dx.doi.org/10.3389/fmicb.2021.788741</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9b897ea192dc4260be9327469069565f |
| identifier_str_mv | 10.3389/fmicb.2021.788741 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25662633 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black FungusSima Tokajian (3559616)Georgi Merhi (12877181)Charbel Al Khoury (13167975)Georges Nemer (295984)Biological sciencesMicrobiologyCOVID-19T2DcorticosteroidsmucormycosisIL-37<p dir="ltr">The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the maxillofacial region, namely mucormycosis, was linked to a deadly infection known as black fungus. Black fungus, diabetes, corticosteroids, and coronavirus disease 2019 (COVID-19) all have a dysregulated immune response in common, which partly could also be attributed to interleukin 37 (IL-37). IL-37, a new cytokine of the IL-1 family, known for broadly reducing innate inflammation as well as acquired immune responses. The use of corticosteroids in diabetic COVID-19 patients, crowded hospitals, and lack of medical oxygen should be carefully considered to reduce COVID-associated secondary infections.</p><p dir="ltr"><br></p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Microbiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmicb.2021.788741" target="_blank">https://dx.doi.org/10.3389/fmicb.2021.788741</a></p>2022-01-13T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fmicb.2021.788741https://figshare.com/articles/journal_contribution/Interleukin-37_A_Link_Between_COVID-19_Diabetes_and_the_Black_Fungus/25662633CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256626332022-01-13T03:00:00Z |
| spellingShingle | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus Sima Tokajian (3559616) Biological sciences Microbiology COVID-19 T2D corticosteroids mucormycosis IL-37 |
| status_str | publishedVersion |
| title | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| title_full | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| title_fullStr | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| title_full_unstemmed | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| title_short | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| title_sort | Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus |
| topic | Biological sciences Microbiology COVID-19 T2D corticosteroids mucormycosis IL-37 |