In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius
<div><p>Mycotoxins are secondary metabolites produced by certain filamentous fungi, causing human and animal health issues upon the ingestion of contaminated food and feed. Among the safest approaches to the control of mycotoxigenic fungi and mycotoxin detoxification is the application o...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2019
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| _version_ | 1864513525969321984 |
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| author | Randa Zeidan (14778388) |
| author2 | Zahoor Ul-Hassan (18090532) Roda Al-Thani (540907) Quirico Migheli (381438) Samir Jaoua (11624805) |
| author2_role | author author author author |
| author_facet | Randa Zeidan (14778388) Zahoor Ul-Hassan (18090532) Roda Al-Thani (540907) Quirico Migheli (381438) Samir Jaoua (11624805) |
| author_role | author |
| dc.creator.none.fl_str_mv | Randa Zeidan (14778388) Zahoor Ul-Hassan (18090532) Roda Al-Thani (540907) Quirico Migheli (381438) Samir Jaoua (11624805) |
| dc.date.none.fl_str_mv | 2019-12-02T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/toxins11120700 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/In-Vitro_Application_of_a_Qatari_Burkholderia_cepacia_strain_QBC03_in_the_Biocontrol_of_Mycotoxigenic_Fungi_and_in_the_Reduction_of_Ochratoxin_A_biosynthesis_by_Aspergillus_carbonarius/25330951 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Ochratoxin A biological control Qatari microflora Burkholderia cepacia thermostability |
| dc.title.none.fl_str_mv | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Mycotoxins are secondary metabolites produced by certain filamentous fungi, causing human and animal health issues upon the ingestion of contaminated food and feed. Among the safest approaches to the control of mycotoxigenic fungi and mycotoxin detoxification is the application of microbial biocontrol agents. Burkholderia cepacia is known for producing metabolites active against a broad number of pathogenic fungi. In this study, the antifungal potential of a Qatari strain of Burkholderia cepacia (QBC03) was explored. QBC03 exhibited antifungal activity against a wide range of mycotoxigenic, as well as phytopathogenic, fungal genera and species. The QBC03 culture supernatant significantly inhibited the growth of Aspergillus carbonarius, Fusarium culmorum and Penicillium verrucosum in PDA medium, as well as A. carbonarius and P. verrucosum biomass in PDB medium. The QBC03 culture supernatant was found to dramatically reduce the synthesis of ochratoxin A (OTA) by A. carbonarius, in addition to inducing mycelia malformation. The antifungal activity of QBC03’s culture extract was retained following thermal treatment at 100 °C for 30 min. The findings of the present study advocate that QBC03 is a suitable biocontrol agent against toxigenic fungi, due to the inhibitory activity of its thermostable metabolites.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Toxins<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/toxins11120700" target="_blank">https://dx.doi.org/10.3390/toxins11120700</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9bb93ac3b14db209d7ea576c046897f9 |
| identifier_str_mv | 10.3390/toxins11120700 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25330951 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonariusRanda Zeidan (14778388)Zahoor Ul-Hassan (18090532)Roda Al-Thani (540907)Quirico Migheli (381438)Samir Jaoua (11624805)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesOchratoxin Abiological controlQatari microfloraBurkholderia cepaciathermostability<div><p>Mycotoxins are secondary metabolites produced by certain filamentous fungi, causing human and animal health issues upon the ingestion of contaminated food and feed. Among the safest approaches to the control of mycotoxigenic fungi and mycotoxin detoxification is the application of microbial biocontrol agents. Burkholderia cepacia is known for producing metabolites active against a broad number of pathogenic fungi. In this study, the antifungal potential of a Qatari strain of Burkholderia cepacia (QBC03) was explored. QBC03 exhibited antifungal activity against a wide range of mycotoxigenic, as well as phytopathogenic, fungal genera and species. The QBC03 culture supernatant significantly inhibited the growth of Aspergillus carbonarius, Fusarium culmorum and Penicillium verrucosum in PDA medium, as well as A. carbonarius and P. verrucosum biomass in PDB medium. The QBC03 culture supernatant was found to dramatically reduce the synthesis of ochratoxin A (OTA) by A. carbonarius, in addition to inducing mycelia malformation. The antifungal activity of QBC03’s culture extract was retained following thermal treatment at 100 °C for 30 min. The findings of the present study advocate that QBC03 is a suitable biocontrol agent against toxigenic fungi, due to the inhibitory activity of its thermostable metabolites.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Toxins<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/toxins11120700" target="_blank">https://dx.doi.org/10.3390/toxins11120700</a></p>2019-12-02T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/toxins11120700https://figshare.com/articles/journal_contribution/In-Vitro_Application_of_a_Qatari_Burkholderia_cepacia_strain_QBC03_in_the_Biocontrol_of_Mycotoxigenic_Fungi_and_in_the_Reduction_of_Ochratoxin_A_biosynthesis_by_Aspergillus_carbonarius/25330951CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253309512019-12-02T03:00:00Z |
| spellingShingle | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius Randa Zeidan (14778388) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Ochratoxin A biological control Qatari microflora Burkholderia cepacia thermostability |
| status_str | publishedVersion |
| title | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| title_full | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| title_fullStr | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| title_full_unstemmed | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| title_short | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| title_sort | In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Ochratoxin A biological control Qatari microflora Burkholderia cepacia thermostability |