Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

<h3>Background</h3><p dir="ltr">Trisomy 21 (T21) is associated with intellectual disability that ranges from mild to profound with an average intellectual quotient of around 50. Furthermore, T21 patients have a high risk of developing Alzheimer’s disease (AD) early in lif...

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Main Author: Larissa Haertle (3864310) (author)
Other Authors: Tobias Müller (163591) (author), Roy Lardenoije (6689108) (author), Anna Maierhofer (4017935) (author), Marcus Dittrich (167737) (author), Renzo J. M. Riemens (18618934) (author), Samantha Stora (8132457) (author), Mathilde Roche (8132460) (author), Markus Leber (573362) (author), Steffi Riedel-Heller (434691) (author), Michael Wagner (56165) (author), Martin Scherer (434692) (author), Aimé Ravel (144418) (author), Clotilde Mircher (254970) (author), Cecile Cieuta-Walti (8132463) (author), Sophie Durand (5639963) (author), Daniel L. A. van de Hove (18618937) (author), Per Hoffmann (429526) (author), Alfredo Ramirez (361375) (author), Thomas Haaf (342924) (author), Nady El Hajj (686554) (author), André Mégarbané (5649685) (author)
Published: 2019
Subjects:
Biological sciences
Genetics
Trisomy 21
DNA methylation
Intellectual disability
Down syndrome
Cognitive function
Alzheimer’s disease
Infinium Methylation EPIC arrays
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