Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy
<h3>Rationale</h3><p dir="ltr">Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. Most pediatric PHEOs are functional tumors, and clinical manifestations are related to catecholamine hypersecretion and/or tumor mas...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513563365736448 |
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| author | Zlatan Zvizdic (9212371) |
| author2 | Mirsad Selimovic (16515276) Amira Mesic (16515279) Dusko Anic (16515282) Verica Misanovic (16515285) Faruk Skenderi (6616190) Semir Vranic (3353012) |
| author2_role | author author author author author author |
| author_facet | Zlatan Zvizdic (9212371) Mirsad Selimovic (16515276) Amira Mesic (16515279) Dusko Anic (16515282) Verica Misanovic (16515285) Faruk Skenderi (6616190) Semir Vranic (3353012) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zlatan Zvizdic (9212371) Mirsad Selimovic (16515276) Amira Mesic (16515279) Dusko Anic (16515282) Verica Misanovic (16515285) Faruk Skenderi (6616190) Semir Vranic (3353012) |
| dc.date.none.fl_str_mv | 2021-01-29T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1097/md.0000000000024303 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Unexpected_adrenal_pheochromocytoma_associated_with_a_generalized_tonic-clonic_seizure_in_a_prepubertal_boy/23650467 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Oncology and carcinogenesis adrenal gland children Pheochromocytoma seizure treatment |
| dc.title.none.fl_str_mv | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Rationale</h3><p dir="ltr">Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. Most pediatric PHEOs are functional tumors, and clinical manifestations are related to catecholamine hypersecretion and/or tumor mass effects.</p><h3>Patient concerns</h3><p dir="ltr">We report here a case of a 10-year-old boy with a highly functional adrenal PHEO detected after the evaluation of a generalized tonic-clonic seizure in the patient. His vital signs at admission were: blood pressure up to 220/135 mm Hg; pulse, 112 beats/min; temperature, 37.4°C; respiratory rate, 22 breaths/min.</p><h3>Diagnosis</h3><p dir="ltr">A 24-hour urine collection for catecholamines test showed a marked increase in Vanillylmandelic acid levels (338.9 μmol/L). An abdominal magnetic resonance imaging revealed a well-defined left adrenal gland mass measuring ∼5 cm in its largest dimension.</p><h3>Interventions</h3><p dir="ltr">The mass was surgically removed, and histopathological examination revealed PHEO with low malignant potential (Adrenal Gland Scaled Score/PASS/ < 4).</p><h3>Outcomes</h3><p dir="ltr">The patient was discharged on the 10th postoperative day in good condition. At 24-month follow-up, the patient was doing well without complications such as tumor recurrence, elevated blood pressure, and seizure.</p><h3>Lessons</h3><p dir="ltr">PHEO should be considered in the differential diagnosis of children with seizures presenting in the emergency department. A multidisciplinary approach to the evaluation and treatment of PHEO is also crucial for a successful outcome.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1097/md.0000000000024303" target="_blank">http://dx.doi.org/10.1097/md.0000000000024303</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9c47f888f7a3df76af14cda08ac63d3e |
| identifier_str_mv | 10.1097/md.0000000000024303 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23650467 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boyZlatan Zvizdic (9212371)Mirsad Selimovic (16515276)Amira Mesic (16515279)Dusko Anic (16515282)Verica Misanovic (16515285)Faruk Skenderi (6616190)Semir Vranic (3353012)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesOncology and carcinogenesisadrenal glandchildrenPheochromocytomaseizuretreatment<h3>Rationale</h3><p dir="ltr">Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. Most pediatric PHEOs are functional tumors, and clinical manifestations are related to catecholamine hypersecretion and/or tumor mass effects.</p><h3>Patient concerns</h3><p dir="ltr">We report here a case of a 10-year-old boy with a highly functional adrenal PHEO detected after the evaluation of a generalized tonic-clonic seizure in the patient. His vital signs at admission were: blood pressure up to 220/135 mm Hg; pulse, 112 beats/min; temperature, 37.4°C; respiratory rate, 22 breaths/min.</p><h3>Diagnosis</h3><p dir="ltr">A 24-hour urine collection for catecholamines test showed a marked increase in Vanillylmandelic acid levels (338.9 μmol/L). An abdominal magnetic resonance imaging revealed a well-defined left adrenal gland mass measuring ∼5 cm in its largest dimension.</p><h3>Interventions</h3><p dir="ltr">The mass was surgically removed, and histopathological examination revealed PHEO with low malignant potential (Adrenal Gland Scaled Score/PASS/ < 4).</p><h3>Outcomes</h3><p dir="ltr">The patient was discharged on the 10th postoperative day in good condition. At 24-month follow-up, the patient was doing well without complications such as tumor recurrence, elevated blood pressure, and seizure.</p><h3>Lessons</h3><p dir="ltr">PHEO should be considered in the differential diagnosis of children with seizures presenting in the emergency department. A multidisciplinary approach to the evaluation and treatment of PHEO is also crucial for a successful outcome.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1097/md.0000000000024303" target="_blank">http://dx.doi.org/10.1097/md.0000000000024303</a></p>2021-01-29T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1097/md.0000000000024303https://figshare.com/articles/journal_contribution/Unexpected_adrenal_pheochromocytoma_associated_with_a_generalized_tonic-clonic_seizure_in_a_prepubertal_boy/23650467CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/236504672021-01-29T03:00:00Z |
| spellingShingle | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy Zlatan Zvizdic (9212371) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Oncology and carcinogenesis adrenal gland children Pheochromocytoma seizure treatment |
| status_str | publishedVersion |
| title | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| title_full | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| title_fullStr | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| title_full_unstemmed | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| title_short | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| title_sort | Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Oncology and carcinogenesis adrenal gland children Pheochromocytoma seizure treatment |