A review of movement disorders in chemotherapy-induced neurotoxicity
<p dir="ltr">Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with ch...
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2021
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| _version_ | 1864513549607370752 |
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| author | Allison B. Wang (14153307) |
| author2 | Stephen N. Housley (11731476) Ann Marie Flores (14153310) Sheetal M. Kircher (14153313) Eric J. Perreault (11768162) Timothy C. Cope (11731485) |
| author2_role | author author author author author |
| author_facet | Allison B. Wang (14153307) Stephen N. Housley (11731476) Ann Marie Flores (14153310) Sheetal M. Kircher (14153313) Eric J. Perreault (11768162) Timothy C. Cope (11731485) |
| author_role | author |
| dc.creator.none.fl_str_mv | Allison B. Wang (14153307) Stephen N. Housley (11731476) Ann Marie Flores (14153310) Sheetal M. Kircher (14153313) Eric J. Perreault (11768162) Timothy C. Cope (11731485) |
| dc.date.none.fl_str_mv | 2021-01-25T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12984-021-00818-2 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_review_of_movement_disorders_in_chemotherapy-induced_neurotoxicity/28929470 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Oncology and carcinogenesis Health sciences Sports science and exercise Cancer Chemotherapy Neuropathy CIPN Sensorimotor dysfunction |
| dc.title.none.fl_str_mv | A review of movement disorders in chemotherapy-induced neurotoxicity |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with chemotherapy are known largely through self-reported symptoms and functional limitations. There are few quantitative studies of specific movement deficits, limiting our understanding of dysfunction, as well as effective assessments and interventions. The aim of this narrative review is to consolidate the current understanding of sensorimotor disabilities based on quantitative measures in cancer survivors who received chemotherapy. We performed literature searches on PubMed and found 32 relevant movement studies. We categorized these studies into three themes based on the movement deficits investigated: (1) balance and postural control; (2) gait function; (3) upper limb function. This literature suggests that cancer survivors have increased postural sway, more conservative gait patterns, and suboptimal hand function compared to healthy individuals. More studies are needed that use objective measures of sensorimotor function to better characterize movement disabilities and investigate the underlying causes, as required for developing targeted assessments and interventions. By updating our understanding of movement impairments in this population, we identify significant gaps in knowledge that will help guide the direction of future research.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of NeuroEngineering and Rehabilitation<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12984-021-00818-2" target="_blank">https://dx.doi.org/10.1186/s12984-021-00818-2</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9cd562272a3df54663908af584a5ef3b |
| identifier_str_mv | 10.1186/s12984-021-00818-2 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28929470 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A review of movement disorders in chemotherapy-induced neurotoxicityAllison B. Wang (14153307)Stephen N. Housley (11731476)Ann Marie Flores (14153310)Sheetal M. Kircher (14153313)Eric J. Perreault (11768162)Timothy C. Cope (11731485)Biomedical and clinical sciencesNeurosciencesOncology and carcinogenesisHealth sciencesSports science and exerciseCancerChemotherapyNeuropathyCIPNSensorimotor dysfunction<p dir="ltr">Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with chemotherapy are known largely through self-reported symptoms and functional limitations. There are few quantitative studies of specific movement deficits, limiting our understanding of dysfunction, as well as effective assessments and interventions. The aim of this narrative review is to consolidate the current understanding of sensorimotor disabilities based on quantitative measures in cancer survivors who received chemotherapy. We performed literature searches on PubMed and found 32 relevant movement studies. We categorized these studies into three themes based on the movement deficits investigated: (1) balance and postural control; (2) gait function; (3) upper limb function. This literature suggests that cancer survivors have increased postural sway, more conservative gait patterns, and suboptimal hand function compared to healthy individuals. More studies are needed that use objective measures of sensorimotor function to better characterize movement disabilities and investigate the underlying causes, as required for developing targeted assessments and interventions. By updating our understanding of movement impairments in this population, we identify significant gaps in knowledge that will help guide the direction of future research.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of NeuroEngineering and Rehabilitation<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12984-021-00818-2" target="_blank">https://dx.doi.org/10.1186/s12984-021-00818-2</a></p>2021-01-25T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12984-021-00818-2https://figshare.com/articles/journal_contribution/A_review_of_movement_disorders_in_chemotherapy-induced_neurotoxicity/28929470CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/289294702021-01-25T09:00:00Z |
| spellingShingle | A review of movement disorders in chemotherapy-induced neurotoxicity Allison B. Wang (14153307) Biomedical and clinical sciences Neurosciences Oncology and carcinogenesis Health sciences Sports science and exercise Cancer Chemotherapy Neuropathy CIPN Sensorimotor dysfunction |
| status_str | publishedVersion |
| title | A review of movement disorders in chemotherapy-induced neurotoxicity |
| title_full | A review of movement disorders in chemotherapy-induced neurotoxicity |
| title_fullStr | A review of movement disorders in chemotherapy-induced neurotoxicity |
| title_full_unstemmed | A review of movement disorders in chemotherapy-induced neurotoxicity |
| title_short | A review of movement disorders in chemotherapy-induced neurotoxicity |
| title_sort | A review of movement disorders in chemotherapy-induced neurotoxicity |
| topic | Biomedical and clinical sciences Neurosciences Oncology and carcinogenesis Health sciences Sports science and exercise Cancer Chemotherapy Neuropathy CIPN Sensorimotor dysfunction |