Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study
<p dir="ltr">Anemia is a global health problem, and the most common cause is iron deficiency anemia (IDA). Although blood transfusion is considered for patients with hemoglobin (Hb) values below 7 g/dl, the optimal transfusion threshold for slowly developing anemia in ambulatory pati...
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2025
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| _version_ | 1864513550025752576 |
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| author | Obaidullah Zafar (17910572) |
| author2 | Suha Turkmen (50126) Haris Iftikhar (15954223) Jassim Mohammad (21165296) Tarek Alrefi (21165299) Alamgir Qureshi (21165302) Adel Alhariri (21165305) Ebtesam Eltayeb (21165308) Serdar Karakulukcu (21165311) Mariam Almalaheem (21165314) |
| author2_role | author author author author author author author author author |
| author_facet | Obaidullah Zafar (17910572) Suha Turkmen (50126) Haris Iftikhar (15954223) Jassim Mohammad (21165296) Tarek Alrefi (21165299) Alamgir Qureshi (21165302) Adel Alhariri (21165305) Ebtesam Eltayeb (21165308) Serdar Karakulukcu (21165311) Mariam Almalaheem (21165314) |
| author_role | author |
| dc.creator.none.fl_str_mv | Obaidullah Zafar (17910572) Suha Turkmen (50126) Haris Iftikhar (15954223) Jassim Mohammad (21165296) Tarek Alrefi (21165299) Alamgir Qureshi (21165302) Adel Alhariri (21165305) Ebtesam Eltayeb (21165308) Serdar Karakulukcu (21165311) Mariam Almalaheem (21165314) |
| dc.date.none.fl_str_mv | 2025-04-14T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s42399-025-01840-4 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Effectiveness_of_Intravenous_Iron_Therapy_in_the_Management_of_Severe_Iron_Deficiency_Anemia_A_Retrospective_Study/28846523 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical biochemistry and metabolomics Health sciences Public health Anemia Iron deficiency Blood transfusion Intravenous iron therapy |
| dc.title.none.fl_str_mv | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Anemia is a global health problem, and the most common cause is iron deficiency anemia (IDA). Although blood transfusion is considered for patients with hemoglobin (Hb) values below 7 g/dl, the optimal transfusion threshold for slowly developing anemia in ambulatory patients has not been clearly defined. IDA can progress slowly, allowing the hemodynamic system to compensate and prevent symptoms, even at very low hemoglobin levels, particularly in young, healthy individuals. Transfusion decisions should be individualized to the severity of symptoms rather than simply hemoglobin levels. The aim of this study is to retrospectively evaluate outpatients with iron deficiency anemia who refused blood transfusion and were treated with intravenous iron supplementation. This study is a retrospective study based on medical records. The patients with Hb level below 7 were found from medical records. The patients who did not undergo blood transfusion and were treated with IV iron were identified. The response to parenteral iron replacement therapy in severe IDA was evaluated in terms of improvement in hemoglobin, hematocrit, and ferritin levels and whether any complications developed. The study included 84 patients, with 89.3% being women and 10.7% men, and an average age of 35.1 years. The most common symptoms reported were fatigue, dizziness, and pallor. Hemoglobin levels significantly increased from 6.4 to 11.1 g/dl (<i>p</i> < 0.001) after IV iron treatment, as did ferritin levels, while total iron-binding capacity decreased. No complications, mortality, or morbidity were reported. Anemia such as IDA may develop without serious symptoms, even if Hb levels are below 7. It is important to manage these individuals with personalized care rather than relying solely on Hb levels for blood transfusion decisions. IV iron therapy can effectively raise Hb levels and reduce associated risks by reducing unnecessary blood transfusions. These findings highlight the need for individualized IV iron therapy as a first-line treatment in young healthy patients to improve outcomes and optimize healthcare resources.</p><h2>Other Information</h2><p dir="ltr">Published in: SN Comprehensive Clinical Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s42399-025-01840-4" target="_blank">https://dx.doi.org/10.1007/s42399-025-01840-4</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9d319177e3f2bf1363d8a3e3800ccbea |
| identifier_str_mv | 10.1007/s42399-025-01840-4 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28846523 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective StudyObaidullah Zafar (17910572)Suha Turkmen (50126)Haris Iftikhar (15954223)Jassim Mohammad (21165296)Tarek Alrefi (21165299)Alamgir Qureshi (21165302)Adel Alhariri (21165305)Ebtesam Eltayeb (21165308)Serdar Karakulukcu (21165311)Mariam Almalaheem (21165314)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesMedical biochemistry and metabolomicsHealth sciencesPublic healthAnemiaIron deficiencyBlood transfusionIntravenous iron therapy<p dir="ltr">Anemia is a global health problem, and the most common cause is iron deficiency anemia (IDA). Although blood transfusion is considered for patients with hemoglobin (Hb) values below 7 g/dl, the optimal transfusion threshold for slowly developing anemia in ambulatory patients has not been clearly defined. IDA can progress slowly, allowing the hemodynamic system to compensate and prevent symptoms, even at very low hemoglobin levels, particularly in young, healthy individuals. Transfusion decisions should be individualized to the severity of symptoms rather than simply hemoglobin levels. The aim of this study is to retrospectively evaluate outpatients with iron deficiency anemia who refused blood transfusion and were treated with intravenous iron supplementation. This study is a retrospective study based on medical records. The patients with Hb level below 7 were found from medical records. The patients who did not undergo blood transfusion and were treated with IV iron were identified. The response to parenteral iron replacement therapy in severe IDA was evaluated in terms of improvement in hemoglobin, hematocrit, and ferritin levels and whether any complications developed. The study included 84 patients, with 89.3% being women and 10.7% men, and an average age of 35.1 years. The most common symptoms reported were fatigue, dizziness, and pallor. Hemoglobin levels significantly increased from 6.4 to 11.1 g/dl (<i>p</i> < 0.001) after IV iron treatment, as did ferritin levels, while total iron-binding capacity decreased. No complications, mortality, or morbidity were reported. Anemia such as IDA may develop without serious symptoms, even if Hb levels are below 7. It is important to manage these individuals with personalized care rather than relying solely on Hb levels for blood transfusion decisions. IV iron therapy can effectively raise Hb levels and reduce associated risks by reducing unnecessary blood transfusions. These findings highlight the need for individualized IV iron therapy as a first-line treatment in young healthy patients to improve outcomes and optimize healthcare resources.</p><h2>Other Information</h2><p dir="ltr">Published in: SN Comprehensive Clinical Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s42399-025-01840-4" target="_blank">https://dx.doi.org/10.1007/s42399-025-01840-4</a></p>2025-04-14T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s42399-025-01840-4https://figshare.com/articles/journal_contribution/Effectiveness_of_Intravenous_Iron_Therapy_in_the_Management_of_Severe_Iron_Deficiency_Anemia_A_Retrospective_Study/28846523CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/288465232025-04-14T09:00:00Z |
| spellingShingle | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study Obaidullah Zafar (17910572) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical biochemistry and metabolomics Health sciences Public health Anemia Iron deficiency Blood transfusion Intravenous iron therapy |
| status_str | publishedVersion |
| title | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| title_full | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| title_fullStr | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| title_full_unstemmed | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| title_short | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| title_sort | Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical biochemistry and metabolomics Health sciences Public health Anemia Iron deficiency Blood transfusion Intravenous iron therapy |