Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review
<h2>Background</h2> <p>This scoping review systematically summarized the available evidence about the efficacy of N-acetyl cysteine (NAC) as an intracanal antibacterial and/or anti-inflammatory.</p> <h2>Methods</h2> <p>PubMed, Scopus, Web of Science, and Goo...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513566616322048 |
|---|---|
| author | Saleem Abdulrab (14153148) |
| author2 | Nawras Mostafa (14153151) Sadeq Ali Al-Maweri (10412616) Hisham Abada (14153154) Esam Halboub (6302024) Hatem A. Alhadainy (14153157) |
| author2_role | author author author author author |
| author_facet | Saleem Abdulrab (14153148) Nawras Mostafa (14153151) Sadeq Ali Al-Maweri (10412616) Hisham Abada (14153154) Esam Halboub (6302024) Hatem A. Alhadainy (14153157) |
| author_role | author |
| dc.creator.none.fl_str_mv | Saleem Abdulrab (14153148) Nawras Mostafa (14153151) Sadeq Ali Al-Maweri (10412616) Hisham Abada (14153154) Esam Halboub (6302024) Hatem A. Alhadainy (14153157) |
| dc.date.none.fl_str_mv | 2022-11-22T21:17:51Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12903-022-02433-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Antibacterial_and_anti-inflammatory_efficacy_of_N-acetyl_cysteine_in_endodontic_treatment_a_scoping_review/21598356 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Dentistry General Dentistry |
| dc.title.none.fl_str_mv | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Background</h2> <p>This scoping review systematically summarized the available evidence about the efficacy of N-acetyl cysteine (NAC) as an intracanal antibacterial and/or anti-inflammatory.</p> <h2>Methods</h2> <p>PubMed, Scopus, Web of Science, and Google scholar search engines/databases were searched up to February 2022 to retrieve relevant studies. The studies were evaluated for eligibility criteria, and identifying relevant studies.</p> <h2>Results</h2> <p>Out of 193 studies, 15 fulfilled the inclusion criteria and were processed for data extraction. Thirteen in vitro studies assessed antibacterial/antibiofilm efficacy of NAC, and reported good and promising efficacy: NAC was found as efficacious as the comparators (chlorhexidine, sodium hypochlorite, calcium hydroxide), or even showed higher efficacy. Regarding the anti-inflammatory efficacy of NAC, one in vitro study found it equivalent to, while one clinical trial revealed it more efficacious than calcium hydroxide.</p> <h2>Conclusions</h2> <p>There is accumulating evidence on the anti-microbial and anti-inflammatory efficacy of NAC in context of endodontics. However, further clinical trials with robust methodology and objective and reliable clinical, biological and microbial outcomes are warranted to translate its use for clinical practice on humans.</p><h2>Other Information</h2> <p> Published in: BMC Oral Health<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12903-022-02433-6" target="_blank">http://dx.doi.org/10.1186/s12903-022-02433-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9da04a4ccc83ba8fab10fbf1d5f1e157 |
| identifier_str_mv | 10.1186/s12903-022-02433-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598356 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping reviewSaleem Abdulrab (14153148)Nawras Mostafa (14153151)Sadeq Ali Al-Maweri (10412616)Hisham Abada (14153154)Esam Halboub (6302024)Hatem A. Alhadainy (14153157)DentistryGeneral Dentistry<h2>Background</h2> <p>This scoping review systematically summarized the available evidence about the efficacy of N-acetyl cysteine (NAC) as an intracanal antibacterial and/or anti-inflammatory.</p> <h2>Methods</h2> <p>PubMed, Scopus, Web of Science, and Google scholar search engines/databases were searched up to February 2022 to retrieve relevant studies. The studies were evaluated for eligibility criteria, and identifying relevant studies.</p> <h2>Results</h2> <p>Out of 193 studies, 15 fulfilled the inclusion criteria and were processed for data extraction. Thirteen in vitro studies assessed antibacterial/antibiofilm efficacy of NAC, and reported good and promising efficacy: NAC was found as efficacious as the comparators (chlorhexidine, sodium hypochlorite, calcium hydroxide), or even showed higher efficacy. Regarding the anti-inflammatory efficacy of NAC, one in vitro study found it equivalent to, while one clinical trial revealed it more efficacious than calcium hydroxide.</p> <h2>Conclusions</h2> <p>There is accumulating evidence on the anti-microbial and anti-inflammatory efficacy of NAC in context of endodontics. However, further clinical trials with robust methodology and objective and reliable clinical, biological and microbial outcomes are warranted to translate its use for clinical practice on humans.</p><h2>Other Information</h2> <p> Published in: BMC Oral Health<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12903-022-02433-6" target="_blank">http://dx.doi.org/10.1186/s12903-022-02433-6</a></p>2022-11-22T21:17:51ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12903-022-02433-6https://figshare.com/articles/journal_contribution/Antibacterial_and_anti-inflammatory_efficacy_of_N-acetyl_cysteine_in_endodontic_treatment_a_scoping_review/21598356CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215983562022-11-22T21:17:51Z |
| spellingShingle | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review Saleem Abdulrab (14153148) Dentistry General Dentistry |
| status_str | publishedVersion |
| title | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| title_full | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| title_fullStr | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| title_full_unstemmed | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| title_short | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| title_sort | Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review |
| topic | Dentistry General Dentistry |