Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery
<div><p> Background. Recovery of motor function after stroke appears to be related to the integrity of axonal connections in the corticospinal tract (CST) and corpus callosum, which may both be affected after cortical stroke. Objective. In the present study, we aimed to elucidate the rel...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , , |
| Published: |
2021
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513517844955136 |
|---|---|
| author | Michel R. T. Sinke (11468697) |
| author2 | Geralda A. F. van Tilborg (8341629) Anu E. Meerwaldt (8871287) Caroline L. van Heijningen (10536833) Annette van der Toorn (2083051) Milou Straathof (8341626) Fazle Rakib (5768069) Mohamed H. M. Ali (5768066) Khalid Al-Saad (5768084) Willem M. Otte (10668534) Rick M. Dijkhuizen (316059) |
| author2_role | author author author author author author author author author author |
| author_facet | Michel R. T. Sinke (11468697) Geralda A. F. van Tilborg (8341629) Anu E. Meerwaldt (8871287) Caroline L. van Heijningen (10536833) Annette van der Toorn (2083051) Milou Straathof (8341626) Fazle Rakib (5768069) Mohamed H. M. Ali (5768066) Khalid Al-Saad (5768084) Willem M. Otte (10668534) Rick M. Dijkhuizen (316059) |
| author_role | author |
| dc.creator.none.fl_str_mv | Michel R. T. Sinke (11468697) Geralda A. F. van Tilborg (8341629) Anu E. Meerwaldt (8871287) Caroline L. van Heijningen (10536833) Annette van der Toorn (2083051) Milou Straathof (8341626) Fazle Rakib (5768069) Mohamed H. M. Ali (5768066) Khalid Al-Saad (5768084) Willem M. Otte (10668534) Rick M. Dijkhuizen (316059) |
| dc.date.none.fl_str_mv | 2021-09-21T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1177/15459683211041318 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Remote_Corticospinal_Tract_Degeneration_After_Cortical_Stroke_in_Rats_May_Not_Preclude_Spontaneous_Sensorimotor_Recovery/25709832 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences brain stroke corticospinal tract diffusion magnetic resonance imaging diffusion tractography behavior |
| dc.title.none.fl_str_mv | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p> Background. Recovery of motor function after stroke appears to be related to the integrity of axonal connections in the corticospinal tract (CST) and corpus callosum, which may both be affected after cortical stroke. Objective. In the present study, we aimed to elucidate the relationship of changes in measures of the CST and transcallosal tract integrity, with the interhemispheric functional connectivity and sensorimotor performance after experimental cortical stroke. Methods. We conducted in vivo diffusion magnetic resonance imaging (MRI), resting-state functional MRI, and behavior testing in twenty-five male Sprague Dawley rats recovering from unilateral photothrombotic stroke in the sensorimotor cortex. Twenty-three healthy rats served as controls. Results. A reduction in the number of reconstructed fibers, a lower fractional anisotropy, and higher radial diffusivity in the ipsilesional but intact CST, reflected remote white matter degeneration. In contrast, transcallosal tract integrity remained preserved. Functional connectivity between the ipsi- and contralesional forelimb regions of the primary somatosensory cortex significantly reduced at week 8 post-stroke. Comparably, usage of the stroke-affected forelimb was normal at week 28, following significant initial impairment between day 1 and week 8 post-stroke. Conclusions. Our study shows that post-stroke motor recovery is possible despite degeneration in the CST and may be supported by intact neuronal communication between hemispheres. </p><p> </p></div><h2>Other Information</h2> <p> Published in: Neurorehabilitation and Neural Repair<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1177/15459683211041318" target="_blank">https://dx.doi.org/10.1177/15459683211041318</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9dc271733f3bbb226eb7fdbe4edbc9d4 |
| identifier_str_mv | 10.1177/15459683211041318 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25709832 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor RecoveryMichel R. T. Sinke (11468697)Geralda A. F. van Tilborg (8341629)Anu E. Meerwaldt (8871287)Caroline L. van Heijningen (10536833)Annette van der Toorn (2083051)Milou Straathof (8341626)Fazle Rakib (5768069)Mohamed H. M. Ali (5768066)Khalid Al-Saad (5768084)Willem M. Otte (10668534)Rick M. Dijkhuizen (316059)Biomedical and clinical sciencesNeurosciencesbrainstrokecorticospinal tractdiffusion magnetic resonance imagingdiffusion tractographybehavior<div><p> Background. Recovery of motor function after stroke appears to be related to the integrity of axonal connections in the corticospinal tract (CST) and corpus callosum, which may both be affected after cortical stroke. Objective. In the present study, we aimed to elucidate the relationship of changes in measures of the CST and transcallosal tract integrity, with the interhemispheric functional connectivity and sensorimotor performance after experimental cortical stroke. Methods. We conducted in vivo diffusion magnetic resonance imaging (MRI), resting-state functional MRI, and behavior testing in twenty-five male Sprague Dawley rats recovering from unilateral photothrombotic stroke in the sensorimotor cortex. Twenty-three healthy rats served as controls. Results. A reduction in the number of reconstructed fibers, a lower fractional anisotropy, and higher radial diffusivity in the ipsilesional but intact CST, reflected remote white matter degeneration. In contrast, transcallosal tract integrity remained preserved. Functional connectivity between the ipsi- and contralesional forelimb regions of the primary somatosensory cortex significantly reduced at week 8 post-stroke. Comparably, usage of the stroke-affected forelimb was normal at week 28, following significant initial impairment between day 1 and week 8 post-stroke. Conclusions. Our study shows that post-stroke motor recovery is possible despite degeneration in the CST and may be supported by intact neuronal communication between hemispheres. </p><p> </p></div><h2>Other Information</h2> <p> Published in: Neurorehabilitation and Neural Repair<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1177/15459683211041318" target="_blank">https://dx.doi.org/10.1177/15459683211041318</a></p>2021-09-21T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1177/15459683211041318https://figshare.com/articles/journal_contribution/Remote_Corticospinal_Tract_Degeneration_After_Cortical_Stroke_in_Rats_May_Not_Preclude_Spontaneous_Sensorimotor_Recovery/25709832CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257098322021-09-21T03:00:00Z |
| spellingShingle | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery Michel R. T. Sinke (11468697) Biomedical and clinical sciences Neurosciences brain stroke corticospinal tract diffusion magnetic resonance imaging diffusion tractography behavior |
| status_str | publishedVersion |
| title | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| title_full | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| title_fullStr | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| title_full_unstemmed | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| title_short | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| title_sort | Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery |
| topic | Biomedical and clinical sciences Neurosciences brain stroke corticospinal tract diffusion magnetic resonance imaging diffusion tractography behavior |