Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite
<p dir="ltr">In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without <u>sodium tripolyphosphate</u>. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macroph...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513549137608704 |
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| author | Mothanna Sadiq Al-Qubaisi (17844218) |
| author2 | Ashwaq Shakir Al-Abboodi (21323177) Fatah H. Alhassan (17844212) Samer Hussein-Al-Ali (21323180) Moayad Husein Flaifel (21323183) Eltayeb E.M. Eid (20402225) Hussah Abdullah Alshwyeh (16621140) Mohd Zobir Hussein (5558990) Sulaiman Mohammed Alnasser (16713520) Mohammed Ibrahim Saeed (21323186) Abdullah Rasedee (6940799) Wisam Nabeel Ibrahim (13899337) |
| author2_role | author author author author author author author author author author author |
| author_facet | Mothanna Sadiq Al-Qubaisi (17844218) Ashwaq Shakir Al-Abboodi (21323177) Fatah H. Alhassan (17844212) Samer Hussein-Al-Ali (21323180) Moayad Husein Flaifel (21323183) Eltayeb E.M. Eid (20402225) Hussah Abdullah Alshwyeh (16621140) Mohd Zobir Hussein (5558990) Sulaiman Mohammed Alnasser (16713520) Mohammed Ibrahim Saeed (21323186) Abdullah Rasedee (6940799) Wisam Nabeel Ibrahim (13899337) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mothanna Sadiq Al-Qubaisi (17844218) Ashwaq Shakir Al-Abboodi (21323177) Fatah H. Alhassan (17844212) Samer Hussein-Al-Ali (21323180) Moayad Husein Flaifel (21323183) Eltayeb E.M. Eid (20402225) Hussah Abdullah Alshwyeh (16621140) Mohd Zobir Hussein (5558990) Sulaiman Mohammed Alnasser (16713520) Mohammed Ibrahim Saeed (21323186) Abdullah Rasedee (6940799) Wisam Nabeel Ibrahim (13899337) |
| dc.date.none.fl_str_mv | 2022-04-27T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jsps.2022.02.002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Preparation_characterization_in_vitro_drug_release_and_anti-inflammatory_of_thymoquinone-loaded_chitosan_nanocomposite/29021459 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Thymoquinone Nanocomposite High-pressure homogenizer Drug release RAW 264.7 cells Inflammatory mediators |
| dc.title.none.fl_str_mv | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without <u>sodium tripolyphosphate</u>. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of <u>nitric oxide,</u> <u>prostaglandin E2</u>, tumor necrosis factor-α, interleukin-6, and interleukin-1β. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorporated in the highly thermal stable<u> nanoparticles</u>. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclusion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective anti-inflammatory therapeutic compound.</p><h2>Other Information</h2><p dir="ltr">Published in: Saudi Pharmaceutical Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jsps.2022.02.002" target="_blank">https://dx.doi.org/10.1016/j.jsps.2022.02.002</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9e2c78658e73736db52045705aa899d6 |
| identifier_str_mv | 10.1016/j.jsps.2022.02.002 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29021459 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocompositeMothanna Sadiq Al-Qubaisi (17844218)Ashwaq Shakir Al-Abboodi (21323177)Fatah H. Alhassan (17844212)Samer Hussein-Al-Ali (21323180)Moayad Husein Flaifel (21323183)Eltayeb E.M. Eid (20402225)Hussah Abdullah Alshwyeh (16621140)Mohd Zobir Hussein (5558990)Sulaiman Mohammed Alnasser (16713520)Mohammed Ibrahim Saeed (21323186)Abdullah Rasedee (6940799)Wisam Nabeel Ibrahim (13899337)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesThymoquinoneNanocompositeHigh-pressure homogenizerDrug releaseRAW 264.7 cellsInflammatory mediators<p dir="ltr">In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without <u>sodium tripolyphosphate</u>. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of <u>nitric oxide,</u> <u>prostaglandin E2</u>, tumor necrosis factor-α, interleukin-6, and interleukin-1β. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorporated in the highly thermal stable<u> nanoparticles</u>. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclusion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective anti-inflammatory therapeutic compound.</p><h2>Other Information</h2><p dir="ltr">Published in: Saudi Pharmaceutical Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jsps.2022.02.002" target="_blank">https://dx.doi.org/10.1016/j.jsps.2022.02.002</a></p>2022-04-27T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jsps.2022.02.002https://figshare.com/articles/journal_contribution/Preparation_characterization_in_vitro_drug_release_and_anti-inflammatory_of_thymoquinone-loaded_chitosan_nanocomposite/29021459CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290214592022-04-27T09:00:00Z |
| spellingShingle | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite Mothanna Sadiq Al-Qubaisi (17844218) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Thymoquinone Nanocomposite High-pressure homogenizer Drug release RAW 264.7 cells Inflammatory mediators |
| status_str | publishedVersion |
| title | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| title_full | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| title_fullStr | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| title_full_unstemmed | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| title_short | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| title_sort | Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Thymoquinone Nanocomposite High-pressure homogenizer Drug release RAW 264.7 cells Inflammatory mediators |