Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
<p dir="ltr">Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that have been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished propertie...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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| _version_ | 1864513558819110912 |
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| author | Sabah Akhtar (5809925) |
| author2 | Shireen Hourani (8879702) Lubna Therachiyil (4246156) Abdullah Al-Dhfyan (4260961) Abdelali Agouni (181926) Asad Zeidan (8879705) Shahab Uddin (154400) Hesham M. Korashy (1474849) |
| author2_role | author author author author author author author |
| author_facet | Sabah Akhtar (5809925) Shireen Hourani (8879702) Lubna Therachiyil (4246156) Abdullah Al-Dhfyan (4260961) Abdelali Agouni (181926) Asad Zeidan (8879705) Shahab Uddin (154400) Hesham M. Korashy (1474849) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sabah Akhtar (5809925) Shireen Hourani (8879702) Lubna Therachiyil (4246156) Abdullah Al-Dhfyan (4260961) Abdelali Agouni (181926) Asad Zeidan (8879705) Shahab Uddin (154400) Hesham M. Korashy (1474849) |
| dc.date.none.fl_str_mv | 2022-08-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcancer.2020.08.014 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epigenetic_Regulation_of_Cancer_Stem_Cells_by_the_Aryl_Hydrocarbon_Receptor_Pathway/24270286 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer stem cells Aryl hydrocarbon receptor Epigenesis Histone modification DNA methylation MicroRNAs Chemoresistance CYP1A1 CYP1B1 |
| dc.title.none.fl_str_mv | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that have been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished properties of CSCs have raised interest in understanding the molecular mechanisms that govern the maintenance of these cells. Numerous experimental and epidemiological studies have demonstrated that exposure to environmental toxins such as the polycyclic aromatic hydrocarbons (PAHs) is strongly involved in cancer initiation and progression. The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Several recent studies have investigated the role of AhR in CSCs self-renewal and maintenance, however the molecular mechanisms and particularly the epigenetic regulations of CSCs by the AhR/CYP1A pathway have not been reviewed before. In this review, we first summarize the crosstalk between AhR and cancer genetics, with a particular emphasis on the mechanisms relevant to CSCs such as Wnt/β-catenin, Notch, NF-κB, and PTEN-PI3K/Akt signaling pathways. The second part of this review discusses the recent advances and studies highlighting the epigenetic mechanisms mediated by the AhR/CYP1A pathway that control CSC gene expression, self-renewal, and chemoresistance in various human cancers. Furthermore, the review also sheds light on the importance of targeting the epigenetic pathways as a novel therapeutic approach against CSCs.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2020.08.014" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2020.08.014</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9f006a7b0f3b6ebbb8317adcba9a9d55 |
| identifier_str_mv | 10.1016/j.semcancer.2020.08.014 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24270286 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor PathwaySabah Akhtar (5809925)Shireen Hourani (8879702)Lubna Therachiyil (4246156)Abdullah Al-Dhfyan (4260961)Abdelali Agouni (181926)Asad Zeidan (8879705)Shahab Uddin (154400)Hesham M. Korashy (1474849)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesCancer stem cellsAryl hydrocarbon receptorEpigenesisHistone modificationDNA methylationMicroRNAsChemoresistanceCYP1A1CYP1B1<p dir="ltr">Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that have been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished properties of CSCs have raised interest in understanding the molecular mechanisms that govern the maintenance of these cells. Numerous experimental and epidemiological studies have demonstrated that exposure to environmental toxins such as the polycyclic aromatic hydrocarbons (PAHs) is strongly involved in cancer initiation and progression. The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Several recent studies have investigated the role of AhR in CSCs self-renewal and maintenance, however the molecular mechanisms and particularly the epigenetic regulations of CSCs by the AhR/CYP1A pathway have not been reviewed before. In this review, we first summarize the crosstalk between AhR and cancer genetics, with a particular emphasis on the mechanisms relevant to CSCs such as Wnt/β-catenin, Notch, NF-κB, and PTEN-PI3K/Akt signaling pathways. The second part of this review discusses the recent advances and studies highlighting the epigenetic mechanisms mediated by the AhR/CYP1A pathway that control CSC gene expression, self-renewal, and chemoresistance in various human cancers. Furthermore, the review also sheds light on the importance of targeting the epigenetic pathways as a novel therapeutic approach against CSCs.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2020.08.014" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2020.08.014</a></p>2022-08-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcancer.2020.08.014https://figshare.com/articles/journal_contribution/Epigenetic_Regulation_of_Cancer_Stem_Cells_by_the_Aryl_Hydrocarbon_Receptor_Pathway/24270286CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242702862022-08-01T00:00:00Z |
| spellingShingle | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway Sabah Akhtar (5809925) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer stem cells Aryl hydrocarbon receptor Epigenesis Histone modification DNA methylation MicroRNAs Chemoresistance CYP1A1 CYP1B1 |
| status_str | publishedVersion |
| title | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_full | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_fullStr | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_full_unstemmed | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_short | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| title_sort | Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer stem cells Aryl hydrocarbon receptor Epigenesis Histone modification DNA methylation MicroRNAs Chemoresistance CYP1A1 CYP1B1 |