Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021
<h3>Background</h3><p dir="ltr">Epidemiology of Neisseria gonorrhoeae (NG) infection remains inadequately understood.</p><h3>Aim</h3><p dir="ltr">We aimed to characterise NG epidemiology in Europe.</p><h3>Methods</h3><...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2024
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513509715345408 |
|---|---|
| author | Omar Chidiac (3158871) |
| author2 | Sawsan AlMukdad (8421963) Manale Harfouche (4557211) Emma Harding-Esch (372207) Laith J Abu-Raddad (11868161) |
| author2_role | author author author author |
| author_facet | Omar Chidiac (3158871) Sawsan AlMukdad (8421963) Manale Harfouche (4557211) Emma Harding-Esch (372207) Laith J Abu-Raddad (11868161) |
| author_role | author |
| dc.creator.none.fl_str_mv | Omar Chidiac (3158871) Sawsan AlMukdad (8421963) Manale Harfouche (4557211) Emma Harding-Esch (372207) Laith J Abu-Raddad (11868161) |
| dc.date.none.fl_str_mv | 2024-02-29T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2807/1560-7917.es.2024.29.9.2300226 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epidemiology_of_gonorrhoea_systematic_review_meta-analyses_and_meta-regressions_World_Health_Organization_European_Region_1949_to_2021/26490970 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Epidemiology Public health Sexually Transmitted Infection (STI) Neisseria gonorrhoeae Urogenital Infections Pelvic Inflammatory Disease (PID) Infertility Oropharyngeal Infections World Health Organization (WHO) |
| dc.title.none.fl_str_mv | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Epidemiology of Neisseria gonorrhoeae (NG) infection remains inadequately understood.</p><h3>Aim</h3><p dir="ltr">We aimed to characterise NG epidemiology in Europe.</p><h3>Methods</h3><p dir="ltr">We used Cochrane and PRISMA guidelines to systematically review, report, synthesise and analyse NG prevalence data from 1949 to 30 September 2021. Random-effects meta-analyses estimated pooled prevalence. Meta-regression analyses investigated associations and sources of heterogeneity.</p><h3>Results</h3><p dir="ltr">The 844 included publications yielded 1,573 prevalence measures. Pooled prevalence of current urogenital infection was 1.0% (95% CI: 0.7–1.2%) among general populations, 3.2% (95% CI: 1.8–4.8%) among female sex workers, 4.9% (95% CI: 4.2–5.6%) among sexually transmitted infection clinic attendees and 12.1% (95% CI: 8.8–15.8%) among symptomatic men. Among men who have sex with men, pooled prevalence was 0.9% (95% CI: 0.5–1.4%), 5.6% (95% CI: 3.6–8.1%), and 3.8% (95% CI: 2.5–5.4%), respectively, for current urogenital, anorectal or oropharyngeal infection. Current urogenital, anorectal or oropharyngeal infection was 1.45-fold (95% CI: 1.19–1.77%), 2.75-fold (95% CI: 1.89–4.02%) and 2.64-fold (95% CI: 1.77–3.93%) higher among men than women. Current urogenital infection declined 0.97-fold (95% CI: 0.96–0.98%) yearly, but anorectal and oropharyngeal infection increased (1.02-fold; 95% CI: 1.01–1.04% and 1.02-fold; 95% CI: 1.00–1.04%), respectively.</p><h3>Conclusions</h3><p dir="ltr">Neisseria gonorrhoeae epidemiology in Europe has distinct and contrasting epidemiologies for vaginal sex transmission in heterosexual sex networks vs anal and oral sex transmission in MSM sexual networks. Increased transmission may facilitate drug-resistant strain emergence. Europe is far from achieving the World Health Organization target of 90% incidence reduction by 2030.</p><h2>Other Information</h2><p dir="ltr">Published in: Eurosurveillance<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2807/1560-7917.es.2024.29.9.2300226" target="_blank">https://dx.doi.org/10.2807/1560-7917.es.2024.29.9.2300226</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_9f4989a96f0393f1051180a9b9fc9830 |
| identifier_str_mv | 10.2807/1560-7917.es.2024.29.9.2300226 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26490970 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021Omar Chidiac (3158871)Sawsan AlMukdad (8421963)Manale Harfouche (4557211)Emma Harding-Esch (372207)Laith J Abu-Raddad (11868161)Health sciencesEpidemiologyPublic healthSexually Transmitted Infection (STI)Neisseria gonorrhoeaeUrogenital InfectionsPelvic Inflammatory Disease (PID)InfertilityOropharyngeal InfectionsWorld Health Organization (WHO)<h3>Background</h3><p dir="ltr">Epidemiology of Neisseria gonorrhoeae (NG) infection remains inadequately understood.</p><h3>Aim</h3><p dir="ltr">We aimed to characterise NG epidemiology in Europe.</p><h3>Methods</h3><p dir="ltr">We used Cochrane and PRISMA guidelines to systematically review, report, synthesise and analyse NG prevalence data from 1949 to 30 September 2021. Random-effects meta-analyses estimated pooled prevalence. Meta-regression analyses investigated associations and sources of heterogeneity.</p><h3>Results</h3><p dir="ltr">The 844 included publications yielded 1,573 prevalence measures. Pooled prevalence of current urogenital infection was 1.0% (95% CI: 0.7–1.2%) among general populations, 3.2% (95% CI: 1.8–4.8%) among female sex workers, 4.9% (95% CI: 4.2–5.6%) among sexually transmitted infection clinic attendees and 12.1% (95% CI: 8.8–15.8%) among symptomatic men. Among men who have sex with men, pooled prevalence was 0.9% (95% CI: 0.5–1.4%), 5.6% (95% CI: 3.6–8.1%), and 3.8% (95% CI: 2.5–5.4%), respectively, for current urogenital, anorectal or oropharyngeal infection. Current urogenital, anorectal or oropharyngeal infection was 1.45-fold (95% CI: 1.19–1.77%), 2.75-fold (95% CI: 1.89–4.02%) and 2.64-fold (95% CI: 1.77–3.93%) higher among men than women. Current urogenital infection declined 0.97-fold (95% CI: 0.96–0.98%) yearly, but anorectal and oropharyngeal infection increased (1.02-fold; 95% CI: 1.01–1.04% and 1.02-fold; 95% CI: 1.00–1.04%), respectively.</p><h3>Conclusions</h3><p dir="ltr">Neisseria gonorrhoeae epidemiology in Europe has distinct and contrasting epidemiologies for vaginal sex transmission in heterosexual sex networks vs anal and oral sex transmission in MSM sexual networks. Increased transmission may facilitate drug-resistant strain emergence. Europe is far from achieving the World Health Organization target of 90% incidence reduction by 2030.</p><h2>Other Information</h2><p dir="ltr">Published in: Eurosurveillance<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2807/1560-7917.es.2024.29.9.2300226" target="_blank">https://dx.doi.org/10.2807/1560-7917.es.2024.29.9.2300226</a></p>2024-02-29T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2807/1560-7917.es.2024.29.9.2300226https://figshare.com/articles/journal_contribution/Epidemiology_of_gonorrhoea_systematic_review_meta-analyses_and_meta-regressions_World_Health_Organization_European_Region_1949_to_2021/26490970CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/264909702024-02-29T09:00:00Z |
| spellingShingle | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 Omar Chidiac (3158871) Health sciences Epidemiology Public health Sexually Transmitted Infection (STI) Neisseria gonorrhoeae Urogenital Infections Pelvic Inflammatory Disease (PID) Infertility Oropharyngeal Infections World Health Organization (WHO) |
| status_str | publishedVersion |
| title | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| title_full | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| title_fullStr | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| title_full_unstemmed | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| title_short | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| title_sort | Epidemiology of gonorrhoea: systematic review, meta-analyses, and meta-regressions, World Health Organization European Region, 1949 to 2021 |
| topic | Health sciences Epidemiology Public health Sexually Transmitted Infection (STI) Neisseria gonorrhoeae Urogenital Infections Pelvic Inflammatory Disease (PID) Infertility Oropharyngeal Infections World Health Organization (WHO) |