A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort
<p>The association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cause and cancer-specific mortality. Out of 49,259 participants, we analysed data on...
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| مؤلفون آخرون: | , , |
| منشور في: |
2022
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| _version_ | 1864513566643585024 |
|---|---|
| author | Ula Nur (4513558) |
| author2 | Darline El Reda (7248407) Dana Hashim (5944358) Elisabete Weiderpass (49201) |
| author2_role | author author author |
| author_facet | Ula Nur (4513558) Darline El Reda (7248407) Dana Hashim (5944358) Elisabete Weiderpass (49201) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ula Nur (4513558) Darline El Reda (7248407) Dana Hashim (5944358) Elisabete Weiderpass (49201) |
| dc.date.none.fl_str_mv | 2022-11-22T21:17:42Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12885-019-5985-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_prospective_investigation_of_oral_contraceptive_use_and_breast_cancer_mortality_findings_from_the_Swedish_women_s_lifestyle_and_health_cohort/21598323 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetics Oncology and carcinogenesis Cancer Research Genetics Oncology |
| dc.title.none.fl_str_mv | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>The association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cause and cancer-specific mortality. Out of 49,259 participants, we analysed data on 2120 (4.3%) women diagnosed with first primary breast cancer between 1993 and 2012, in the Swedish Women’s Lifestyle and Health Study. Kaplan–Meier plots were used to graph the hazard of mortality in association with oral contraceptives use, stage of disease and hormone receptors status at diagnosis. Cox proportional hazard model were used to estimate hazard ratios (HR) between OC use and all-cause mortality. The same association was studied for breast cancer-specific mortality by modelling the log cumulative mortality risk, adjusting for clinical stage at diagnosis, hormone receptor status, body mass index and smoking. Among 2120 women with breast cancer, 1268 (84%) reported ever use of OC and 254 died within 10 years of diagnosis. The risk of death for OC ever-users relative to never-users was: HR = 1.13 (95% CI: 0.66–1.94) for all-cause mortality and HR = 1.29 (95% CI: 0.53–3.18) for breast cancer-specific mortality. A high percentage of women (42.9%) were diagnosed at early stage disease (stage I). Among women with primary breast cancer, OC ever-users compared to never- users did not have a higher all-cause or breast cancer specific-mortality, after the adjustment of risk factors.</p><h2>Other Information</h2> <p> Published in: BMC Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12885-019-5985-6" target="_blank">http://dx.doi.org/10.1186/s12885-019-5985-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a0639df1756d1c212577a619d497b615 |
| identifier_str_mv | 10.1186/s12885-019-5985-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598323 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohortUla Nur (4513558)Darline El Reda (7248407)Dana Hashim (5944358)Elisabete Weiderpass (49201)GeneticsOncology and carcinogenesisCancer ResearchGeneticsOncology<p>The association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cause and cancer-specific mortality. Out of 49,259 participants, we analysed data on 2120 (4.3%) women diagnosed with first primary breast cancer between 1993 and 2012, in the Swedish Women’s Lifestyle and Health Study. Kaplan–Meier plots were used to graph the hazard of mortality in association with oral contraceptives use, stage of disease and hormone receptors status at diagnosis. Cox proportional hazard model were used to estimate hazard ratios (HR) between OC use and all-cause mortality. The same association was studied for breast cancer-specific mortality by modelling the log cumulative mortality risk, adjusting for clinical stage at diagnosis, hormone receptor status, body mass index and smoking. Among 2120 women with breast cancer, 1268 (84%) reported ever use of OC and 254 died within 10 years of diagnosis. The risk of death for OC ever-users relative to never-users was: HR = 1.13 (95% CI: 0.66–1.94) for all-cause mortality and HR = 1.29 (95% CI: 0.53–3.18) for breast cancer-specific mortality. A high percentage of women (42.9%) were diagnosed at early stage disease (stage I). Among women with primary breast cancer, OC ever-users compared to never- users did not have a higher all-cause or breast cancer specific-mortality, after the adjustment of risk factors.</p><h2>Other Information</h2> <p> Published in: BMC Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12885-019-5985-6" target="_blank">http://dx.doi.org/10.1186/s12885-019-5985-6</a></p>2022-11-22T21:17:42ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12885-019-5985-6https://figshare.com/articles/journal_contribution/A_prospective_investigation_of_oral_contraceptive_use_and_breast_cancer_mortality_findings_from_the_Swedish_women_s_lifestyle_and_health_cohort/21598323CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215983232022-11-22T21:17:42Z |
| spellingShingle | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort Ula Nur (4513558) Genetics Oncology and carcinogenesis Cancer Research Genetics Oncology |
| status_str | publishedVersion |
| title | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| title_full | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| title_fullStr | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| title_full_unstemmed | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| title_short | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| title_sort | A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort |
| topic | Genetics Oncology and carcinogenesis Cancer Research Genetics Oncology |