The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects
<h3>Purpose</h3><p dir="ltr">Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513519840395264 |
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| author | Ayman Alzu'bi (18192898) |
| author2 | Worood Bani Baker (18192901) Bahaa Al-Trad (3574976) Mazhar Salim Al Zoubi (17863880) Manal Isam AbuAlArjah (18192904) Ejlal Abu-El-Rub (5168183) Lena Tahat (18192907) Ahmed MNZ Helaly (18192910) Doaa S. Ghorab (18192913) Waseem El-Huneidi (541647) Raed M. Al-Zoubi (2037490) |
| author2_role | author author author author author author author author author author |
| author_facet | Ayman Alzu'bi (18192898) Worood Bani Baker (18192901) Bahaa Al-Trad (3574976) Mazhar Salim Al Zoubi (17863880) Manal Isam AbuAlArjah (18192904) Ejlal Abu-El-Rub (5168183) Lena Tahat (18192907) Ahmed MNZ Helaly (18192910) Doaa S. Ghorab (18192913) Waseem El-Huneidi (541647) Raed M. Al-Zoubi (2037490) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ayman Alzu'bi (18192898) Worood Bani Baker (18192901) Bahaa Al-Trad (3574976) Mazhar Salim Al Zoubi (17863880) Manal Isam AbuAlArjah (18192904) Ejlal Abu-El-Rub (5168183) Lena Tahat (18192907) Ahmed MNZ Helaly (18192910) Doaa S. Ghorab (18192913) Waseem El-Huneidi (541647) Raed M. Al-Zoubi (2037490) |
| dc.date.none.fl_str_mv | 2024-04-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.brainresbull.2024.110917 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_impact_of_chronic_fentanyl_administration_on_the_cerebral_cortex_in_mice_Molecular_and_histological_effects/25449580 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Fentanyl Neurotoxicity Oxidative Stress Neuroinflammation Apoptosis |
| dc.title.none.fl_str_mv | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model.</p><p><br></p><h3>Methods</h3><p dir="ltr">Adult male Balb/c mice were chronically treated with low (0.05 mg/kg, i.p) and high (0.1 mg/kg, i.p) doses of fentanyl for 5 consecutive weeks, and various neurotoxic parameters, including apoptosis, oxidative stress, and neuroinflammatory response were assessed in the cortex. Potential histological as well as neurochemical changes were also evaluated.</p><p><br></p><h3>Results</h3><p dir="ltr">The results of this study show that chronic fentanyl administration induced intense levels of apoptosis, oxidative stress, and neuroinflammation in the cerebral cortex. These findings were found to be correlated with histopathological characteristics of neural degeneration and white matter injury. Moreover, fentanyl administration was found to reduce the expression of both NMDA receptor subunits and dopamine receptors and elevate the level of epidermal growth factor (EGF).</p><p><br></p><h3>Conclusion</h3><p dir="ltr">Fentanyl administration induced neurotoxic effects in the mouse cerebral cortex that could be primarily mediated by the evoked oxidative-inflammatory response. The altered expression of NMDA receptors, dopamine receptors, and EGF suggests the pernicious effects of fentanyl addiction that may end in the development of toxic psychosis.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain Research Bulletin<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.brainresbull.2024.110917" target="_blank">https://dx.doi.org/10.1016/j.brainresbull.2024.110917</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a0aa66b49e2793a4ed137826d68129d2 |
| identifier_str_mv | 10.1016/j.brainresbull.2024.110917 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25449580 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effectsAyman Alzu'bi (18192898)Worood Bani Baker (18192901)Bahaa Al-Trad (3574976)Mazhar Salim Al Zoubi (17863880)Manal Isam AbuAlArjah (18192904)Ejlal Abu-El-Rub (5168183)Lena Tahat (18192907)Ahmed MNZ Helaly (18192910)Doaa S. Ghorab (18192913)Waseem El-Huneidi (541647)Raed M. Al-Zoubi (2037490)Biomedical and clinical sciencesNeurosciencesFentanylNeurotoxicityOxidative StressNeuroinflammationApoptosis<h3>Purpose</h3><p dir="ltr">Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model.</p><p><br></p><h3>Methods</h3><p dir="ltr">Adult male Balb/c mice were chronically treated with low (0.05 mg/kg, i.p) and high (0.1 mg/kg, i.p) doses of fentanyl for 5 consecutive weeks, and various neurotoxic parameters, including apoptosis, oxidative stress, and neuroinflammatory response were assessed in the cortex. Potential histological as well as neurochemical changes were also evaluated.</p><p><br></p><h3>Results</h3><p dir="ltr">The results of this study show that chronic fentanyl administration induced intense levels of apoptosis, oxidative stress, and neuroinflammation in the cerebral cortex. These findings were found to be correlated with histopathological characteristics of neural degeneration and white matter injury. Moreover, fentanyl administration was found to reduce the expression of both NMDA receptor subunits and dopamine receptors and elevate the level of epidermal growth factor (EGF).</p><p><br></p><h3>Conclusion</h3><p dir="ltr">Fentanyl administration induced neurotoxic effects in the mouse cerebral cortex that could be primarily mediated by the evoked oxidative-inflammatory response. The altered expression of NMDA receptors, dopamine receptors, and EGF suggests the pernicious effects of fentanyl addiction that may end in the development of toxic psychosis.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain Research Bulletin<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.brainresbull.2024.110917" target="_blank">https://dx.doi.org/10.1016/j.brainresbull.2024.110917</a></p>2024-04-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.brainresbull.2024.110917https://figshare.com/articles/journal_contribution/The_impact_of_chronic_fentanyl_administration_on_the_cerebral_cortex_in_mice_Molecular_and_histological_effects/25449580CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/254495802024-04-01T00:00:00Z |
| spellingShingle | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects Ayman Alzu'bi (18192898) Biomedical and clinical sciences Neurosciences Fentanyl Neurotoxicity Oxidative Stress Neuroinflammation Apoptosis |
| status_str | publishedVersion |
| title | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| title_full | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| title_fullStr | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| title_full_unstemmed | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| title_short | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| title_sort | The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects |
| topic | Biomedical and clinical sciences Neurosciences Fentanyl Neurotoxicity Oxidative Stress Neuroinflammation Apoptosis |