Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat
<p dir="ltr">The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl<sub>2</sub> in drinking water for 10 weeks follo...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513549566476288 |
|---|---|
| author | Sandra Concepcion Das (14151678) |
| author2 | Kavitha Varadharajan (14778952) Muralitharan Shanmugakonar (14778955) Hamda A. Al-Naemi (14151675) |
| author2_role | author author author |
| author_facet | Sandra Concepcion Das (14151678) Kavitha Varadharajan (14778952) Muralitharan Shanmugakonar (14778955) Hamda A. Al-Naemi (14151675) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sandra Concepcion Das (14151678) Kavitha Varadharajan (14778952) Muralitharan Shanmugakonar (14778955) Hamda A. Al-Naemi (14151675) |
| dc.date.none.fl_str_mv | 2021-08-10T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fphar.2021.663048 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Chronic_Cadmium_Exposure_Alters_Cardiac_Matrix_Metalloproteinases_in_the_Heart_of_Sprague-Dawley_Rat/28930817 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences cadmium cardiac inflammatory cytokines MMP TIMP |
| dc.title.none.fl_str_mv | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl<sub>2</sub> in drinking water for 10 weeks followed by withdrawal of cadmium treatment for 4 weeks. Following the completion of the treatment, gene expression of inflammatory mediators (IL-1<i>β</i>, IL-6, IL-10, TNF-α and NF-κB), protein expression of MMP-2, MMP-9 and their respective inhibitors- TIMP-1 and TIMP-2, and gelatinolytic activity of MMP-2 and MMP-9 were determined. At the protein level, cadmium incites a differential effect on the expression and activity of gelatinases and their endogenous inhibitors in an exposure-dependent manner. Results also show that the administered cadmium dose elicits an inflammatory response until week 10 that slightly diminishes after 4 weeks. This study provides evidence of cadmium-induced imbalance in the MMP-TIMP system in the cardiac tissue. This imbalance may be mediated by cadmium-induced inflammation that could contribute to various cardiovascular pathologies.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Pharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphar.2021.663048" target="_blank">https://dx.doi.org/10.3389/fphar.2021.663048</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a1c11293c8ae9ee6d64278511803b3d1 |
| identifier_str_mv | 10.3389/fphar.2021.663048 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28930817 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley RatSandra Concepcion Das (14151678)Kavitha Varadharajan (14778952)Muralitharan Shanmugakonar (14778955)Hamda A. Al-Naemi (14151675)Biomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencescadmiumcardiacinflammatory cytokinesMMPTIMP<p dir="ltr">The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl<sub>2</sub> in drinking water for 10 weeks followed by withdrawal of cadmium treatment for 4 weeks. Following the completion of the treatment, gene expression of inflammatory mediators (IL-1<i>β</i>, IL-6, IL-10, TNF-α and NF-κB), protein expression of MMP-2, MMP-9 and their respective inhibitors- TIMP-1 and TIMP-2, and gelatinolytic activity of MMP-2 and MMP-9 were determined. At the protein level, cadmium incites a differential effect on the expression and activity of gelatinases and their endogenous inhibitors in an exposure-dependent manner. Results also show that the administered cadmium dose elicits an inflammatory response until week 10 that slightly diminishes after 4 weeks. This study provides evidence of cadmium-induced imbalance in the MMP-TIMP system in the cardiac tissue. This imbalance may be mediated by cadmium-induced inflammation that could contribute to various cardiovascular pathologies.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Pharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphar.2021.663048" target="_blank">https://dx.doi.org/10.3389/fphar.2021.663048</a></p>2021-08-10T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fphar.2021.663048https://figshare.com/articles/journal_contribution/Chronic_Cadmium_Exposure_Alters_Cardiac_Matrix_Metalloproteinases_in_the_Heart_of_Sprague-Dawley_Rat/28930817CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/289308172021-08-10T09:00:00Z |
| spellingShingle | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat Sandra Concepcion Das (14151678) Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences cadmium cardiac inflammatory cytokines MMP TIMP |
| status_str | publishedVersion |
| title | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| title_full | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| title_fullStr | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| title_full_unstemmed | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| title_short | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| title_sort | Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences cadmium cardiac inflammatory cytokines MMP TIMP |