One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes
<h2>Objective</h2> <p>To evaluate the effect of a 1-year hybrid closed-loop (HCL) system on glycemic control in children and adolescents with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI). </p> <h2>Methods</h2> <p>This was a 1...
محفوظ في:
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513567981568000 |
|---|---|
| author | Goran Petrovski (129836) |
| author2 | Fawziya Al Khalaf (9303667) Judith Campbell (5496704) Fareeda Umer (14150688) Douha Almajaly (14150691) Manar Hamdan (14150694) Khalid Hussain (110443) |
| author2_role | author author author author author author |
| author_facet | Goran Petrovski (129836) Fawziya Al Khalaf (9303667) Judith Campbell (5496704) Fareeda Umer (14150688) Douha Almajaly (14150691) Manar Hamdan (14150694) Khalid Hussain (110443) |
| author_role | author |
| dc.creator.none.fl_str_mv | Goran Petrovski (129836) Fawziya Al Khalaf (9303667) Judith Campbell (5496704) Fareeda Umer (14150688) Douha Almajaly (14150691) Manar Hamdan (14150694) Khalid Hussain (110443) |
| dc.date.none.fl_str_mv | 2022-11-22T21:12:32Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00592-020-01607-4 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/One-year_experience_of_hybrid_closed-loop_system_in_children_and_adolescents_with_type_1_diabetes_previously_treated_with_multiple_daily_injections_drivers_to_successful_outcomes/21597108 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical sciences Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Internal Medicine |
| dc.title.none.fl_str_mv | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Objective</h2> <p>To evaluate the effect of a 1-year hybrid closed-loop (HCL) system on glycemic control in children and adolescents with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI). </p> <h2>Methods</h2> <p>This was a 1-year observational study, as a continuation of the previous 3 months prospective study of pediatric patients with T1D conducted at Sidra Medicine in Qatar. The study enrolled individuals aged 7–18 years with T1D > 1 year, on MDI with self-monitoring of blood glucose or continuous glucose monitoring, with no prior pump experience, and with an HbA1c level < 12.5% (< 113 mmol/mol). After the first 3 months of HCL use, patients were followed at 6, 9 and 12 months, where HbA1c was obtained and pump data were collected.</p> <h2>Results</h2> <p>All 30 participants (age 10.24 ± 2.6 years) who initiated HCL completed 12 months of HCL system use in Auto Mode. The participants used the sensor 88.4 ± 6.5% of the time with Auto Mode usage 85.6 ± 7.4% during 12 months of HCL system use. HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline, to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at 3 months (p = 0.02) and remained stable to 7.1 ± 0.6 (54 ± 6.6 mmol/mol) at 12 months (p = 0.02). TIR (70–180 mg/dL) increased from 46.9% at baseline to 71.9% at 1 month and remained above 70% during the 12 months of HCL use.</p> <h2>Conclusion</h2> <p>HCL system (MiniMed 670G) in children and adolescents previously treated with MDI significantly improves glycemic outcomes (HbA1c and Time in Ranges) immediately during the first month. This improved glycemic control was maintained over the 1 year following Auto Mode initiation.</p><h2>Other Information</h2> <p> Published in: Acta Diabetologica<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00592-020-01607-4" target="_blank">http://dx.doi.org/10.1007/s00592-020-01607-4</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a2aa8079aa92100c6792d9bcfb111360 |
| identifier_str_mv | 10.1007/s00592-020-01607-4 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597108 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomesGoran Petrovski (129836)Fawziya Al Khalaf (9303667)Judith Campbell (5496704)Fareeda Umer (14150688)Douha Almajaly (14150691)Manar Hamdan (14150694)Khalid Hussain (110443)Clinical sciencesEndocrinologyGeneral MedicineEndocrinology, Diabetes and MetabolismInternal Medicine<h2>Objective</h2> <p>To evaluate the effect of a 1-year hybrid closed-loop (HCL) system on glycemic control in children and adolescents with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI). </p> <h2>Methods</h2> <p>This was a 1-year observational study, as a continuation of the previous 3 months prospective study of pediatric patients with T1D conducted at Sidra Medicine in Qatar. The study enrolled individuals aged 7–18 years with T1D > 1 year, on MDI with self-monitoring of blood glucose or continuous glucose monitoring, with no prior pump experience, and with an HbA1c level < 12.5% (< 113 mmol/mol). After the first 3 months of HCL use, patients were followed at 6, 9 and 12 months, where HbA1c was obtained and pump data were collected.</p> <h2>Results</h2> <p>All 30 participants (age 10.24 ± 2.6 years) who initiated HCL completed 12 months of HCL system use in Auto Mode. The participants used the sensor 88.4 ± 6.5% of the time with Auto Mode usage 85.6 ± 7.4% during 12 months of HCL system use. HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline, to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at 3 months (p = 0.02) and remained stable to 7.1 ± 0.6 (54 ± 6.6 mmol/mol) at 12 months (p = 0.02). TIR (70–180 mg/dL) increased from 46.9% at baseline to 71.9% at 1 month and remained above 70% during the 12 months of HCL use.</p> <h2>Conclusion</h2> <p>HCL system (MiniMed 670G) in children and adolescents previously treated with MDI significantly improves glycemic outcomes (HbA1c and Time in Ranges) immediately during the first month. This improved glycemic control was maintained over the 1 year following Auto Mode initiation.</p><h2>Other Information</h2> <p> Published in: Acta Diabetologica<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00592-020-01607-4" target="_blank">http://dx.doi.org/10.1007/s00592-020-01607-4</a></p>2022-11-22T21:12:32ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00592-020-01607-4https://figshare.com/articles/journal_contribution/One-year_experience_of_hybrid_closed-loop_system_in_children_and_adolescents_with_type_1_diabetes_previously_treated_with_multiple_daily_injections_drivers_to_successful_outcomes/21597108CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215971082022-11-22T21:12:32Z |
| spellingShingle | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes Goran Petrovski (129836) Clinical sciences Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Internal Medicine |
| status_str | publishedVersion |
| title | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| title_full | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| title_fullStr | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| title_full_unstemmed | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| title_short | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| title_sort | One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes |
| topic | Clinical sciences Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Internal Medicine |