DNA Methylation Biomarkers in Aging and Age-Related Diseases
<p dir="ltr">Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease. It is currently well established that DNA methylation biomarkers can determine biological age of any tissue across the entire human lifespan,...
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2020
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| _version_ | 1864513515388141568 |
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| author | Yasmeen Salameh (8552571) |
| author2 | Yosra Bejaoui (8552574) Nady El Hajj (686554) |
| author2_role | author author |
| author_facet | Yasmeen Salameh (8552571) Yosra Bejaoui (8552574) Nady El Hajj (686554) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yasmeen Salameh (8552571) Yosra Bejaoui (8552574) Nady El Hajj (686554) |
| dc.date.none.fl_str_mv | 2020-03-10T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fgene.2020.00171 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/DNA_Methylation_Biomarkers_in_Aging_and_Age-Related_Diseases/25858942 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Bioinformatics and computational biology Genetics Biomedical and clinical sciences Clinical sciences Neurosciences Health sciences Public health amyloid precursor protein biological marker bisulfite brain derived neurotrophic factor BRCA1 protein C reactive protein genomic DNA glucose hemoglobin A1c high density lipoprotein histone insulin long chain fatty acid coenzyme A ligase phosphatidylinositol serine proteinase inhibitor transcription factor EZH2 triacylglycerol triggering receptor expressed on myeloid cells 2 |
| dc.title.none.fl_str_mv | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease. It is currently well established that DNA methylation biomarkers can determine biological age of any tissue across the entire human lifespan, even during development. There is growing evidence suggesting epigenetic age acceleration to be strongly linked to common diseases or occurring in response to various environmental factors. DNA methylation based clocks are proposed as biomarkers of early disease risk as well as predictors of life expectancy and mortality. In this review, we will summarize key advances in epigenetic clocks and their potential application in precision health. We will also provide an overview of progresses in epigenetic biomarker discovery in Alzheimer’s, type 2 diabetes, and cardiovascular disease. Furthermore, we will highlight the importance of prospective study designs to identify and confirm epigenetic biomarkers of disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2020.00171" target="_blank">https://dx.doi.org/10.3389/fgene.2020.00171</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a4590dd1cb91c8505b82964a7e48e234 |
| identifier_str_mv | 10.3389/fgene.2020.00171 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25858942 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | DNA Methylation Biomarkers in Aging and Age-Related DiseasesYasmeen Salameh (8552571)Yosra Bejaoui (8552574)Nady El Hajj (686554)Biological sciencesBioinformatics and computational biologyGeneticsBiomedical and clinical sciencesClinical sciencesNeurosciencesHealth sciencesPublic healthamyloid precursor proteinbiological markerbisulfitebrain derived neurotrophic factorBRCA1 proteinC reactive proteingenomic DNAglucosehemoglobin A1chigh density lipoproteinhistoneinsulinlong chain fatty acid coenzyme A ligasephosphatidylinositolserine proteinase inhibitortranscription factor EZH2triacylglyceroltriggering receptor expressed on myeloid cells 2<p dir="ltr">Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease. It is currently well established that DNA methylation biomarkers can determine biological age of any tissue across the entire human lifespan, even during development. There is growing evidence suggesting epigenetic age acceleration to be strongly linked to common diseases or occurring in response to various environmental factors. DNA methylation based clocks are proposed as biomarkers of early disease risk as well as predictors of life expectancy and mortality. In this review, we will summarize key advances in epigenetic clocks and their potential application in precision health. We will also provide an overview of progresses in epigenetic biomarker discovery in Alzheimer’s, type 2 diabetes, and cardiovascular disease. Furthermore, we will highlight the importance of prospective study designs to identify and confirm epigenetic biomarkers of disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2020.00171" target="_blank">https://dx.doi.org/10.3389/fgene.2020.00171</a></p>2020-03-10T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fgene.2020.00171https://figshare.com/articles/journal_contribution/DNA_Methylation_Biomarkers_in_Aging_and_Age-Related_Diseases/25858942CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258589422020-03-10T06:00:00Z |
| spellingShingle | DNA Methylation Biomarkers in Aging and Age-Related Diseases Yasmeen Salameh (8552571) Biological sciences Bioinformatics and computational biology Genetics Biomedical and clinical sciences Clinical sciences Neurosciences Health sciences Public health amyloid precursor protein biological marker bisulfite brain derived neurotrophic factor BRCA1 protein C reactive protein genomic DNA glucose hemoglobin A1c high density lipoprotein histone insulin long chain fatty acid coenzyme A ligase phosphatidylinositol serine proteinase inhibitor transcription factor EZH2 triacylglycerol triggering receptor expressed on myeloid cells 2 |
| status_str | publishedVersion |
| title | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| title_full | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| title_fullStr | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| title_full_unstemmed | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| title_short | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| title_sort | DNA Methylation Biomarkers in Aging and Age-Related Diseases |
| topic | Biological sciences Bioinformatics and computational biology Genetics Biomedical and clinical sciences Clinical sciences Neurosciences Health sciences Public health amyloid precursor protein biological marker bisulfite brain derived neurotrophic factor BRCA1 protein C reactive protein genomic DNA glucose hemoglobin A1c high density lipoprotein histone insulin long chain fatty acid coenzyme A ligase phosphatidylinositol serine proteinase inhibitor transcription factor EZH2 triacylglycerol triggering receptor expressed on myeloid cells 2 |