Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
<p>Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as anticancer agents is an acceptable therapeutic approach due to accessibi...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513536178257920 |
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| author | Sheema Hashem (14150961) |
| author2 | Tayyiba Akbar Ali (14152572) Sabah Akhtar (5809925) Sabah Nisar (12561961) Geetanjali Sageena (17562657) Shahid Ali (5778020) Sharefa Al-Mannai (17562660) Lubna Therachiyil (4246156) Rashid Mir (2616949) Imadeldin Elfaki (14153244) Mohammad Muzaffar Mir (17562663) Farrukh Jamal (8605026) Tariq Masoodi (8117702) Shahab Uddin (154400) Mayank Singh (793077) Mohammad Haris (564809) Muzafar Macha (6856403) Ajaz A. Bhat (12984701) |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_facet | Sheema Hashem (14150961) Tayyiba Akbar Ali (14152572) Sabah Akhtar (5809925) Sabah Nisar (12561961) Geetanjali Sageena (17562657) Shahid Ali (5778020) Sharefa Al-Mannai (17562660) Lubna Therachiyil (4246156) Rashid Mir (2616949) Imadeldin Elfaki (14153244) Mohammad Muzaffar Mir (17562663) Farrukh Jamal (8605026) Tariq Masoodi (8117702) Shahab Uddin (154400) Mayank Singh (793077) Mohammad Haris (564809) Muzafar Macha (6856403) Ajaz A. Bhat (12984701) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sheema Hashem (14150961) Tayyiba Akbar Ali (14152572) Sabah Akhtar (5809925) Sabah Nisar (12561961) Geetanjali Sageena (17562657) Shahid Ali (5778020) Sharefa Al-Mannai (17562660) Lubna Therachiyil (4246156) Rashid Mir (2616949) Imadeldin Elfaki (14153244) Mohammad Muzaffar Mir (17562663) Farrukh Jamal (8605026) Tariq Masoodi (8117702) Shahab Uddin (154400) Mayank Singh (793077) Mohammad Haris (564809) Muzafar Macha (6856403) Ajaz A. Bhat (12984701) |
| dc.date.none.fl_str_mv | 2022-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.biopha.2022.113054 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Targeting_cancer_signaling_pathways_by_natural_products_Exploring_promising_anti-cancer_agents/24745125 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Health sciences Traditional, complementary and integrative medicine Apoptosis Natural products ProliferationTumor Signaling pathways |
| dc.title.none.fl_str_mv | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as anticancer agents is an acceptable therapeutic approach due to accessibility, applicability, and reduced cytotoxicity. Natural products have been an incomparable source of anticancer drugs in the modern era of drug discovery. Along with their derivatives and analogs, natural products play a major role in cancer treatment by modulating the cancer microenvironment and different signaling pathways. These compounds are effective against several signaling pathways, mainly cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (Notch pathway, Wnt pathway, and Hedgehog pathway). The historical record of natural products is strong, but there is a need to investigate the current role of natural products in the discovery and development of cancer drugs and determine the possibility of natural products being an important source of future therapeutic agents. Many target-specific anticancer drugs failed to provide successful results, which accounts for a need to investigate natural products with multi-target characteristics to achieve better outcomes. The potential of natural products to be promising novel compounds for cancer treatment makes them an important area of research. This review explores the significance of natural products in inhibiting the various signaling pathways that serve as drivers of carcinogenesis and thus pave the way for developing and discovering anticancer drugs.</p><h2>Other Information</h2> <p> Published in: Biomedicine & Pharmacotherapy<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2022.113054" target="_blank">https://dx.doi.org/10.1016/j.biopha.2022.113054</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a47e4f32b40970d28971636ace14f8ff |
| identifier_str_mv | 10.1016/j.biopha.2022.113054 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745125 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agentsSheema Hashem (14150961)Tayyiba Akbar Ali (14152572)Sabah Akhtar (5809925)Sabah Nisar (12561961)Geetanjali Sageena (17562657)Shahid Ali (5778020)Sharefa Al-Mannai (17562660)Lubna Therachiyil (4246156)Rashid Mir (2616949)Imadeldin Elfaki (14153244)Mohammad Muzaffar Mir (17562663)Farrukh Jamal (8605026)Tariq Masoodi (8117702)Shahab Uddin (154400)Mayank Singh (793077)Mohammad Haris (564809)Muzafar Macha (6856403)Ajaz A. Bhat (12984701)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesChemical sciencesMedicinal and biomolecular chemistryHealth sciencesTraditional, complementary and integrative medicineApoptosisNatural productsProliferationTumorSignaling pathways<p>Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as anticancer agents is an acceptable therapeutic approach due to accessibility, applicability, and reduced cytotoxicity. Natural products have been an incomparable source of anticancer drugs in the modern era of drug discovery. Along with their derivatives and analogs, natural products play a major role in cancer treatment by modulating the cancer microenvironment and different signaling pathways. These compounds are effective against several signaling pathways, mainly cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (Notch pathway, Wnt pathway, and Hedgehog pathway). The historical record of natural products is strong, but there is a need to investigate the current role of natural products in the discovery and development of cancer drugs and determine the possibility of natural products being an important source of future therapeutic agents. Many target-specific anticancer drugs failed to provide successful results, which accounts for a need to investigate natural products with multi-target characteristics to achieve better outcomes. The potential of natural products to be promising novel compounds for cancer treatment makes them an important area of research. This review explores the significance of natural products in inhibiting the various signaling pathways that serve as drivers of carcinogenesis and thus pave the way for developing and discovering anticancer drugs.</p><h2>Other Information</h2> <p> Published in: Biomedicine & Pharmacotherapy<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2022.113054" target="_blank">https://dx.doi.org/10.1016/j.biopha.2022.113054</a></p>2022-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.biopha.2022.113054https://figshare.com/articles/journal_contribution/Targeting_cancer_signaling_pathways_by_natural_products_Exploring_promising_anti-cancer_agents/24745125CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247451252022-06-01T00:00:00Z |
| spellingShingle | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents Sheema Hashem (14150961) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Health sciences Traditional, complementary and integrative medicine Apoptosis Natural products ProliferationTumor Signaling pathways |
| status_str | publishedVersion |
| title | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| title_full | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| title_fullStr | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| title_full_unstemmed | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| title_short | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| title_sort | Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Health sciences Traditional, complementary and integrative medicine Apoptosis Natural products ProliferationTumor Signaling pathways |