Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration
<p dir="ltr">Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca<sup>2+</sup> signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciti...
محفوظ في:
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| منشور في: |
2020
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| الملخص: | <p dir="ltr">Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca<sup>2+</sup> signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciting insights into the role of store-operated Ca<sup>2+</sup> entry (SOCE), Oxysterol-binding protein (OSBP)-related proteins ORP3, Arf5 and the Arf GEF IQSec1 in this crosstalk and how they regulate cell migration and focal adhesion disassembly.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Calcium<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ceca.2020.102226" target="_blank">https://dx.doi.org/10.1016/j.ceca.2020.102226</a></p> |
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